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    TMEM45A transmembrane protein 45A [ Homo sapiens (human) ]

    Gene ID: 55076, updated on 9-Dec-2024

    Summary

    Official Symbol
    TMEM45Aprovided by HGNC
    Official Full Name
    transmembrane protein 45Aprovided by HGNC
    Primary source
    HGNC:HGNC:25480
    See related
    Ensembl:ENSG00000181458 MIM:616928; AllianceGenome:HGNC:25480
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DERP7; DNAPTP4
    Summary
    Predicted to be located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in skin (RPKM 215.6), liver (RPKM 25.9) and 2 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TMEM45A in Genome Data Viewer
    Location:
    3q12.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (100492619..100577444)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (103198293..103283136)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (100211463..100296288)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene translocase of outer mitochondrial membrane 70 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:100118351-100119270 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14571 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20157 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20158 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20159 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:100126809-100127334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:100127335-100127860 Neighboring gene leukemia NUP98 fusion partner 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:100170016-100170553 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:100184868-100185368 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:100195719-100196404 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14573 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:100280470-100281334 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14574 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20161 Neighboring gene adhesion G protein-coupled receptor G7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20162 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20163 Neighboring gene glia maturation factor beta pseudogene 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:100427906-100428797 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:100428798-100429688 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:100456051-100456928 Neighboring gene trafficking from ER to golgi regulator

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ10134

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    transmembrane protein 45A
    Names
    DNA polymerase-transactivated protein 4
    dermal papilla derived protein 7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363876.2NP_001350805.1  transmembrane protein 45A isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC128693
      Consensus CDS
      CCDS87113.1
      UniProtKB/TrEMBL
      J3KQ06
      Conserved Domains (1) summary
      pfam04819
      Location:139256
      DUF716; Family of unknown function (DUF716)
    2. NM_018004.3NP_060474.1  transmembrane protein 45A isoform 2

      See identical proteins and their annotated locations for NP_060474.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC128693, AY450392, BG205309
      Consensus CDS
      CCDS2937.1
      UniProtKB/Swiss-Prot
      Q53YW5, Q9NWC5
      Related
      ENSP00000319009.4, ENST00000323523.8
      Conserved Domains (1) summary
      pfam04819
      Location:123240
      DUF716; Family of unknown function (DUF716)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      100492619..100577444
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047448425.1XP_047304381.1  transmembrane protein 45A isoform X3

      UniProtKB/TrEMBL
      J3KQ06
      Related
      ENSP00000385089.1, ENST00000403410.5
    2. XM_047448427.1XP_047304383.1  transmembrane protein 45A isoform X3

      UniProtKB/TrEMBL
      J3KQ06
    3. XM_047448426.1XP_047304382.1  transmembrane protein 45A isoform X3

      UniProtKB/TrEMBL
      J3KQ06
    4. XM_047448418.1XP_047304374.1  transmembrane protein 45A isoform X1

    5. XM_047448419.1XP_047304375.1  transmembrane protein 45A isoform X1

    6. XM_047448420.1XP_047304376.1  transmembrane protein 45A isoform X1

    7. XM_047448422.1XP_047304378.1  transmembrane protein 45A isoform X2

    8. XM_047448421.1XP_047304377.1  transmembrane protein 45A isoform X1

    9. XM_047448423.1XP_047304379.1  transmembrane protein 45A isoform X2

    10. XM_047448424.1XP_047304380.1  transmembrane protein 45A isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      103198293..103283136
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054347041.1XP_054203016.1  transmembrane protein 45A isoform X3

      UniProtKB/TrEMBL
      J3KQ06
    2. XM_054347043.1XP_054203018.1  transmembrane protein 45A isoform X3

      UniProtKB/TrEMBL
      J3KQ06
    3. XM_054347042.1XP_054203017.1  transmembrane protein 45A isoform X3

      UniProtKB/TrEMBL
      J3KQ06
    4. XM_054347035.1XP_054203010.1  transmembrane protein 45A isoform X1

    5. XM_054347038.1XP_054203013.1  transmembrane protein 45A isoform X1

    6. XM_054347036.1XP_054203011.1  transmembrane protein 45A isoform X1

    7. XM_054347037.1XP_054203012.1  transmembrane protein 45A isoform X1

    8. XM_054347039.1XP_054203014.1  transmembrane protein 45A isoform X2

    9. XM_054347040.1XP_054203015.1  transmembrane protein 45A isoform X2