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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
mRNA and Protein(s)
-
NM_001291571.2 → NP_001278500.1 next to BRCA1 gene 1 protein isoform b
See identical proteins and their annotated locations for NP_001278500.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
- Source sequence(s)
-
AC024051, BC009808, HY045337
- Consensus CDS
-
CCDS77037.1
- UniProtKB/TrEMBL
-
A8K1U0
- Related
- ENSP00000467816.1, ENST00000589872.1
- Conserved Domains (4) summary
-
- cd06396
Location:5 → 85
- PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...
- cd02340
Location:215 → 259
- ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
- cd14947
Location:369 → 479
- NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
- pfam10883
Location:288 → 324
- DUF2681; Protein of unknown function (DUF2681)
-
NM_001291572.2 → NP_001278501.1 next to BRCA1 gene 1 protein isoform c
See identical proteins and their annotated locations for NP_001278501.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 5' coding region, and also lacks two alternate exons that result in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a.
- Source sequence(s)
-
AK299328, AW874218, AY450308
- Consensus CDS
-
CCDS77038.1
- UniProtKB/TrEMBL
- A8K1U0, B7Z5R6
- Related
- ENSP00000437545.1, ENST00000542611.5
- Conserved Domains (4) summary
-
- cd02340
Location:194 → 238
- ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
- cd14947
Location:348 → 458
- NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
- pfam10883
Location:267 → 303
- DUF2681; Protein of unknown function (DUF2681)
- cl02720
Location:5 → 64
- PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...
-
NM_005899.5 → NP_005890.2 next to BRCA1 gene 1 protein isoform a
See identical proteins and their annotated locations for NP_005890.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Both variants 1 and 3 encode isoform a.
- Source sequence(s)
-
AW874218, AY450308, HY045337
- Consensus CDS
-
CCDS45694.1
- UniProtKB/Swiss-Prot
- Q13173, Q14596, Q15026, Q5J7Q8, Q96GB6, Q9NRF7
- UniProtKB/TrEMBL
-
A8K1U0
- Related
- ENSP00000466667.1, ENST00000590996.6
- Conserved Domains (4) summary
-
- cd06396
Location:5 → 85
- PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...
- cd02340
Location:215 → 259
- ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
- cd14319
Location:916 → 954
- UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins
- pfam16158
Location:379 → 478
- N_BRCA1_IG; Ig-like domain from next to BRCA1 gene
-
NM_031862.4 → NP_114068.1 next to BRCA1 gene 1 protein isoform a
See identical proteins and their annotated locations for NP_114068.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants 1 and 3 encode isoform a.
- Source sequence(s)
-
AC060780, AW874218, D30756, DB081342
- Consensus CDS
-
CCDS45694.1
- UniProtKB/Swiss-Prot
- Q13173, Q14596, Q15026, Q5J7Q8, Q96GB6, Q9NRF7
- UniProtKB/TrEMBL
-
A8K1U0
- Related
- ENSP00000343479.5, ENST00000341165.10
- Conserved Domains (4) summary
-
- cd06396
Location:5 → 85
- PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...
- cd02340
Location:215 → 259
- ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
- cd14319
Location:916 → 954
- UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins
- pfam16158
Location:379 → 478
- N_BRCA1_IG; Ig-like domain from next to BRCA1 gene
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000017.11 Reference GRCh38.p14 Primary Assembly
- Range
-
43170409..43211688
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_011524813.3 → XP_011523115.1 next to BRCA1 gene 1 protein isoform X1
See identical proteins and their annotated locations for XP_011523115.1
- UniProtKB/Swiss-Prot
- Q13173, Q14596, Q15026, Q5J7Q8, Q96GB6, Q9NRF7
- UniProtKB/TrEMBL
-
A8K1U0
- Conserved Domains (4) summary
-
- cd06396
Location:5 → 85
- PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...
- cd02340
Location:215 → 259
- ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
- cd14319
Location:916 → 954
- UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins
- pfam16158
Location:379 → 478
- N_BRCA1_IG; Ig-like domain from next to BRCA1 gene
-
XM_017024643.3 → XP_016880132.1 next to BRCA1 gene 1 protein isoform X2
- UniProtKB/TrEMBL
-
A8K1U0
- Conserved Domains (4) summary
-
- cd06396
Location:5 → 85
- PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...
- cd02340
Location:215 → 259
- ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
- cd14319
Location:846 → 884
- UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins
- pfam16158
Location:309 → 408
- N_BRCA1_IG; Ig-like domain from next to BRCA1 gene
-
XM_024450749.2 → XP_024306517.1 next to BRCA1 gene 1 protein isoform X1
- UniProtKB/Swiss-Prot
- Q13173, Q14596, Q15026, Q5J7Q8, Q96GB6, Q9NRF7
- UniProtKB/TrEMBL
-
A8K1U0
- Conserved Domains (4) summary
-
- cd06396
Location:5 → 85
- PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...
- cd02340
Location:215 → 259
- ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
- cd14319
Location:916 → 954
- UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins
- pfam16158
Location:379 → 478
- N_BRCA1_IG; Ig-like domain from next to BRCA1 gene
-
XM_047436061.1 → XP_047292017.1 next to BRCA1 gene 1 protein isoform X1
- UniProtKB/Swiss-Prot
- Q13173, Q14596, Q15026, Q5J7Q8, Q96GB6, Q9NRF7
- UniProtKB/TrEMBL
-
A8K1U0
-
XM_006721903.3 → XP_006721966.1 next to BRCA1 gene 1 protein isoform X2
- UniProtKB/TrEMBL
-
A8K1U0
- Conserved Domains (4) summary
-
- cd06396
Location:5 → 85
- PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...
- cd02340
Location:215 → 259
- ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
- cd14319
Location:846 → 884
- UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins
- pfam16158
Location:309 → 408
- N_BRCA1_IG; Ig-like domain from next to BRCA1 gene
Alternate T2T-CHM13v2.0
Genomic
-
NC_060941.1 Alternate T2T-CHM13v2.0
- Range
-
44026006..44070466
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054316114.1 → XP_054172089.1 next to BRCA1 gene 1 protein isoform X1
- UniProtKB/TrEMBL
-
A8K1U0
-
XM_054316118.1 → XP_054172093.1 next to BRCA1 gene 1 protein isoform X2
- UniProtKB/TrEMBL
-
A8K1U0
-
XM_054316115.1 → XP_054172090.1 next to BRCA1 gene 1 protein isoform X1
- UniProtKB/TrEMBL
-
A8K1U0
-
XM_054316116.1 → XP_054172091.1 next to BRCA1 gene 1 protein isoform X1
- UniProtKB/TrEMBL
-
A8K1U0
-
XM_054316117.1 → XP_054172092.1 next to BRCA1 gene 1 protein isoform X2
- UniProtKB/TrEMBL
-
A8K1U0
The following Reference Sequences have been suppressed. Explain
These RefSeqs were suppressed for the
cited reason(s). Suppressed RefSeqs do not appear in BLAST databases, related
sequence links, or BLAST links (BLink), but may still be retrieved by clicking on
their accession.version below.
-
NM_031858.2: Suppressed sequence
- Description
- NM_031858.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.