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    JCHAIN joining chain of multimeric IgA and IgM [ Homo sapiens (human) ]

    Gene ID: 3512, updated on 3-Dec-2024

    Summary

    Official Symbol
    JCHAINprovided by HGNC
    Official Full Name
    joining chain of multimeric IgA and IgMprovided by HGNC
    Primary source
    HGNC:HGNC:5713
    See related
    Ensembl:ENSG00000132465 MIM:147790; AllianceGenome:HGNC:5713
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IGJ; JCH; IGCJ
    Summary
    Enables IgA binding activity and protein homodimerization activity. Contributes to several functions, including immunoglobulin receptor binding activity; peptidoglycan binding activity; and phosphatidylcholine binding activity. Involved in several processes, including glomerular filtration; innate immune response; and positive regulation of respiratory burst. Located in extracellular space. Part of monomeric IgA immunoglobulin complex; pentameric IgM immunoglobulin complex; and secretory dimeric IgA immunoglobulin complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in colon (RPKM 2264.9), duodenum (RPKM 2014.1) and 10 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See JCHAIN in Genome Data Viewer
    Location:
    4q13.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (70655541..70666508, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (73998009..74019368, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (71521258..71532225, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr4:71464845-71465050 Neighboring gene ameloblastin Neighboring gene enamelin Neighboring gene uncharacterized LOC101927297 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:71553174-71554144 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:71554145-71555113 Neighboring gene UTP3 small subunit processome component

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables IgA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables antigen binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    contributes_to immunoglobulin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to immunoglobulin receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to immunoglobulin receptor binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    contributes_to peptidoglycan binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to phosphatidylcholine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein-macromolecule adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in adaptive immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in antibacterial humoral response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glomerular filtration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in humoral immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in innate immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of respiratory burst IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    immunoglobulin J chain
    Names
    IgJ chain
    J chain
    immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144646.4NP_653247.1  immunoglobulin J chain precursor

      See identical proteins and their annotated locations for NP_653247.1

      Status: VALIDATED

      Source sequence(s)
      BC038982, BP221304, BP418109
      Consensus CDS
      CCDS3545.1
      UniProtKB/Swiss-Prot
      P01591
      UniProtKB/TrEMBL
      D6RD17
      Related
      ENSP00000254801.4, ENST00000254801.9
      Conserved Domains (1) summary
      pfam15097
      Location:24159
      Ig_J_chain; Immunoglobulin J chain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      70655541..70666508 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      73998009..74019368 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054349954.1XP_054205929.1  immunoglobulin J chain isoform X2

      UniProtKB/Swiss-Prot
      P01591
      UniProtKB/TrEMBL
      D6RD17
    2. XM_054349955.1XP_054205930.1  immunoglobulin J chain isoform X2

      UniProtKB/Swiss-Prot
      P01591
      UniProtKB/TrEMBL
      D6RD17
    3. XM_054349953.1XP_054205928.1  immunoglobulin J chain isoform X2

      UniProtKB/Swiss-Prot
      P01591
      UniProtKB/TrEMBL
      D6RD17
    4. XM_054349952.1XP_054205927.1  immunoglobulin J chain isoform X1