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    ADGRG7 adhesion G protein-coupled receptor G7 [ Homo sapiens (human) ]

    Gene ID: 84873, updated on 3-Dec-2024

    Summary

    Official Symbol
    ADGRG7provided by HGNC
    Official Full Name
    adhesion G protein-coupled receptor G7provided by HGNC
    Primary source
    HGNC:HGNC:19241
    See related
    Ensembl:ENSG00000144820 MIM:612307; AllianceGenome:HGNC:19241
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPR128
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in duodenum (RPKM 18.5), small intestine (RPKM 17.4) and 2 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ADGRG7 in Genome Data Viewer
    Location:
    3q12.2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (100609601..100695479)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (103315353..103401238)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (100328445..100414323)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:100126809-100127334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:100127335-100127860 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:100170016-100170553 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:100184868-100185368 Neighboring gene leukemia NUP98 fusion partner 1 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:100195719-100196404 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14573 Neighboring gene transmembrane protein 45A Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:100280470-100281334 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14574 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20161 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20162 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20163 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:100427906-100428797 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:100428798-100429688 Neighboring gene glia maturation factor beta pseudogene 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:100456051-100456928 Neighboring gene trafficking from ER to golgi regulator Neighboring gene uncharacterized LOC124906260 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_63759 Neighboring gene ABI family member 3 binding protein Neighboring gene Sharpr-MPRA regulatory region 7106

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • FLJ14454, FLJ16382, FLJ29035, MGC142011, MGC163260

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    adhesion G-protein coupled receptor G7
    Names
    G-protein coupled receptor 128

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308362.1NP_001295291.1  adhesion G-protein coupled receptor G7 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks multiple alternate exons in the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC069223, AK172769, AK295345, DA640995
      Consensus CDS
      CCDS77778.1
      UniProtKB/TrEMBL
      B7Z303, E9PHI0
      Related
      ENSP00000419788.1, ENST00000475887.1
      Conserved Domains (2) summary
      pfam01825
      Location:88126
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:138419
      7tm_4; Olfactory receptor
    2. NM_032787.3NP_116176.2  adhesion G-protein coupled receptor G7 isoform 1 precursor

      See identical proteins and their annotated locations for NP_116176.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC069223, AK027360, AK172769
      Consensus CDS
      CCDS2938.1
      UniProtKB/Swiss-Prot
      Q14D94, Q86SQ2, Q96K78
      UniProtKB/TrEMBL
      A1L441
      Related
      ENSP00000273352.3, ENST00000273352.8
      Conserved Domains (2) summary
      smart00303
      Location:383422
      GPS; G-protein-coupled receptor proteolytic site domain
      cd15257
      Location:431737
      7tmB2_GPR128; orphan adhesion receptor GPR128, member of the class B2 family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      100609601..100695479
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047449088.1XP_047305044.1  adhesion G-protein coupled receptor G7 isoform X1

      UniProtKB/TrEMBL
      Q6ZMH4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      103315353..103401238
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348147.1XP_054204122.1  adhesion G-protein coupled receptor G7 isoform X1

      UniProtKB/TrEMBL
      Q6ZMH4
    2. XM_054348148.1XP_054204123.1  adhesion G-protein coupled receptor G7 isoform X2

      UniProtKB/TrEMBL
      Q6ZMH4