Oas1b 2'-5' oligoadenylate synthetase 1B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Oas1bprovided by MGI
Official Full Name: 2'-5' oligoadenylate synthetase 1Bprovided by MGI
Primary source: MGI:MGI:97430
See related: Ensembl:ENSMUSG00000029605 AllianceGenome:MGI:97430
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: L1; Flv; Wnv; Oas1; Oias2; Mmu-L1; Oias-2
Summary: This gene is a member of the 2'-5' oligoA synthetase family, which are clustered on chromosome 5. The encoded protein functions in the interferon-regulated OAS/RNase L system, which mediates RNA decay as part of the innate antiviral immunity pathway. The protein binds double-stranded RNA and oligomerizes ATP, which activate the single-stranded RNA cleavage enzyme RNase L. This protein mediates resistance to flaviviruses such as West Nile virus. The majority of wild mouse strains produce a functional protein and are resistant to flavivirus infection, whereas some inbred mouse strains including the strain of the reference genome, C57BL/6J, contain a premature stop codon that inactivates this gene product. [provided by RefSeq, Jul 2008]
Annotation information: Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Expression: Broad expression in thymus adult (RPKM 8.0), spleen adult (RPKM 5.8) and 22 other tissues See more
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Genomic context

Location:: 5 F; 5 60.64 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (120950700..120962228)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (120812635..120824163)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Oligoadenylate synthetase 1 displays dual antiviral mechanisms in driving translational shutdown and protecting interferon production.
Title: Oligoadenylate synthetase 1 displays dual antiviral mechanisms in driving translational shutdown and protecting interferon production.
characterization of ABCF3 protein and its interaction with OAS1B
Title: Biochemical characterization of the mouse ABCF3 protein, a partner of the flavivirus-resistance protein OAS1B.
Oas1b status as wild-type or truncated, and overall Oas1b gene dosage, link with novel innate immune gene signatures that impact specific biological pathways for the control of flavivirus infection and immunity through both Oas1b-dependent and independent processes.
Title: Oas1b-dependent Immune Transcriptional Profiles of West Nile Virus Infection in the Collaborative Cross.
These data indicate that the different susceptibility to the antiviral activity of Oas1b resulted in a difference in neurovirulence in the two tick-borne encephalitis virus strains.
Title: Susceptibility to flavivirus-specific antiviral response of Oas1b affects the neurovirulence of the Far-Eastern subtype of tick-borne encephalitis virus.
Oas1b is part of a complex located in the ER and that ABCF3 is a component of the Flv(r)-mediated resistance mechanism.
Title: Identification of novel host cell binding partners of Oas1b, the protein conferring resistance to flavivirus-induced disease in mice.
Activation of Oas1b gene expression by type I IFN requires only STAT2, not STAT1.
Title: Activation of Oas1a gene expression by type I IFN requires both STAT1 and STAT2 while only STAT2 is required for Oas1b activation.
Oas1b inhibits flavivirus replication by an alternative mechanism that overrides the proviral effect of reducing 2-5A accumulation and RNase L activation.
Title: The Flvr-encoded murine oligoadenylate synthetase 1b (Oas1b) suppresses 2-5A synthesis in intact cells.
Oas1b mice show resistance to the infection of West Nile virus but not of influenza virus.
Title: Generation of congenic mouse strains by introducing the virus-resistant genes, Mx1 and Oas1b, of feral mouse-derived inbred strain MSM/Ms into the common strain C57BL/6J.
Knock-in of the Oas1b resistance allele into a susceptible mouse strain produced mice with the flavivirus resistance phenotype, confirming that this phenotype is mediated by a single gene.
Title: Knock-in of the Oas1b(r) allele into a flavivirus-induced disease susceptible mouse generates the resistant phenotype.
Oas1b represents an antiviral pathway that exerts its inhibitory effect on West Nile virus replication by preventing viral RNA accumulation inside infected cells
Title: The 2',5'-oligoadenylate synthetase 1b is a potent inhibitor of West Nile virus replication inside infected cells.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (3) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
NOT enables 2'-5'-oligoadenylate synthetase activity	IDA Inferred from Direct Assay more info	PubMed
enables 2'-5'-oligoadenylate synthetase activity	ISO Inferred from Sequence Orthology more info
enables double-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in antiviral innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in antiviral innate immune response	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interferon-alpha	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interferon-beta	ISO Inferred from Sequence Orthology more info
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in glucose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in interleukin-27-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of IP-10 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of chemokine (C-X-C motif) ligand 2 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral genome replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of viral genome replication	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cellular respiration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monocyte chemotactic protein-1 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in protein complex oligomerization	ISO Inferred from Sequence Orthology more info
involved_in regulation of ribonuclease activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in response to virus	ISO Inferred from Sequence Orthology more info
involved_in surfactant homeostasis	ISO Inferred from Sequence Orthology more info
involved_in toll-like receptor 3 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in toll-like receptor 4 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in type I interferon-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
colocalizes_with cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in ribosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: inactive 2'-5'-oligoadenylate synthase 1B

Names: (2-5')oligo(A) synthase 1B; (2-5')oligo(A) synthetase 1b; 2'-5'-oligoadenylate synthase-like protein 1; 2'-5'-oligoadenylate synthetase-like protein 1; 2-5A synthase 1B; 2-5A synthetase 1B; Flavivirus resistance

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083925.1 → NP_001077394.1 inactive 2'-5'-oligoadenylate synthase 1B

See identical proteins and their annotated locations for NP_001077394.1

Status: REVIEWED

Description

Transcript Variant: This variant (1, coding) represents the functional allele that is not present in some strains, including the strain of the reference genome.

Source sequence(s)

AF418005

UniProtKB/TrEMBL

A8YPC3, A8YPE4, A8YPE6

Conserved Domains (2) summary

pfam10421
Location:159 → 343

OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

cl11966
Location:30 → 177

NT_Pol-beta-like; Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins

RNA

NR_003507.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (1, non-coding) contains a premature stop codon, and represents the non-functional allele present in some strains, including the strain of the reference genome. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, coding, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC115937, AI326028, AK080152

Related

ENSMUST00000183291.2