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    Lars1 leucyl-tRNA synthetase 1 [ Mus musculus (house mouse) ]

    Gene ID: 107045, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Lars1provided by MGI
    Official Full Name
    leucyl-tRNA synthetase 1provided by MGI
    Primary source
    MGI:MGI:1913808
    See related
    Ensembl:ENSMUSG00000024493 AllianceGenome:MGI:1913808
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lars; leuRS; 2310045K21Rik; 3110009L02Rik
    Summary
    Enables leucine-tRNA ligase activity. Involved in leucyl-tRNA aminoacylation. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in infantile liver failure syndrome 1. Orthologous to human LARS1 (leucyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 11.9), placenta adult (RPKM 10.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lars1 in Genome Data Viewer
    Location:
    18 B3; 18 22.37 cM
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (42335363..42395302, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (42202298..42262237, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene PLAC8-like 1 Neighboring gene predicted gene, 18086 Neighboring gene high mobility group box 1-like pseudogene Neighboring gene STARR-seq mESC enhancer starr_44434 Neighboring gene ribosomal protein S19, pseudogene 4 Neighboring gene STARR-positive B cell enhancer ABC_E494 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:42434622-42434731 Neighboring gene STARR-positive B cell enhancer ABC_E495 Neighboring gene predicted gene 4013 Neighboring gene RNA binding motif protein 27 Neighboring gene STARR-seq mESC enhancer starr_44436

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Leucyl-tRNA Synthetase Contributes to Muscle Weakness through Mammalian Target of Rapamycin Complex 1 Activation and Autophagy Suppression in a Mouse Model of Duchenne Muscular Dystrophy. You JS, et al. Am J Pathol, 2024 Aug. PMID 38762116,
    2. Nontranslational function of leucyl-tRNA synthetase regulates myogenic differentiation and skeletal muscle regeneration. Son K, et al. J Clin Invest, 2019 Apr 15. PMID 30985292, Free PMC Article
    3. Leucyl-tRNA synthetase is a tumour suppressor in breast cancer and regulates codon-dependent translation dynamics. Passarelli MC, et al. Nat Cell Biol, 2022 Mar. PMID 35288656, Free PMC Article
    4. Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1. Yoon I, et al. Science, 2020 Jan 10. PMID 31780625
    5. Up regulation of isoleucyl-tRNA synthetase promotes vascular smooth muscle cells dysfunction via p38 MAPK/PI3K signaling pathways. Li B, et al. Life Sci, 2019 May 1. PMID 30905780

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Leucyl-tRNA Synthetase Contributes to Muscle Weakness through Mammalian Target of Rapamycin Complex 1 Activation and Autophagy Suppression in a Mouse Model of Duchenne Muscular Dystrophy.
      Title: Leucyl-tRNA Synthetase Contributes to Muscle Weakness through Mammalian Target of Rapamycin Complex 1 Activation and Autophagy Suppression in a Mouse Model of Duchenne Muscular Dystrophy.
    2. this study provides evidence for a role of leucyl-tRNA synthetase 1 (LARS1) in glucose-dependent control of leucine usage
      Title: Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1.
    3. leucyl-tRNA synthetase has a nontranslational function in regulating myogenic differentiation and skeletal muscle regeneration
      Title: Nontranslational function of leucyl-tRNA synthetase regulates myogenic differentiation and skeletal muscle regeneration.
    4. High LARS expression is associated with abdominal aortic aneurysm.
      Title: Up regulation of isoleucyl-tRNA synthetase promotes vascular smooth muscle cells dysfunction via p38 MAPK/PI3K signaling pathways.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1352

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aminoacyl-tRNA editing activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aminoacyl-tRNA editing activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glutamine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables leucine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables leucine-tRNA ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables leucine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables leucine-tRNA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in aminoacyl-tRNA metabolism involved in translational fidelity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to L-leucine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to L-leucine ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to amino acid stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to leucine starvation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to leucine starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glutaminyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutaminyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in leucyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in leucyl-tRNA aminoacylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in leucyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of TORC1 signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell size IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell size ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of aminoacyl-tRNA synthetase multienzyme complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of aminoacyl-tRNA synthetase multienzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endomembrane system ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    leucine--tRNA ligase, cytoplasmic
    Names
    leucyl-tRNA synthetase, cytoplasmic
    NP_598898.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134137.3 → NP_598898.2  leucine--tRNA ligase, cytoplasmic

      See identical proteins and their annotated locations for NP_598898.2

      Status: VALIDATED

      Source sequence(s)
      BB652360, BC052715, BE989557
      Consensus CDS
      CCDS37796.1
      UniProtKB/Swiss-Prot
      Q8BKW9, Q8BMJ2
      UniProtKB/TrEMBL
      Q6ZPT2, Q7TSZ3
      Related
      ENSMUSP00000095197.4, ENSMUST00000097590.5
      Conserved Domains (5) summary
      cd07959
      Location:757 → 876
      Anticodon_Ia_Leu_AEc; Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases
      cd00812
      Location:527 → 759
      LeuRS_core; catalytic core domain of leucyl-tRNA synthetases
      PLN02959
      Location:3 → 1064
      PLN02959; aminoacyl-tRNA ligase
      cl00015
      Location:47 → 231
      nt_trans; nucleotidyl transferase superfamily
      cl12020
      Location:858 → 907
      Anticodon_Ia_like; Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      42335363..42395302 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001782319.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BMJ2.2 GenPept UniProtKB/Swiss-Prot:Q8BMJ2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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