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    Mettl15 methyltransferase like 15 [ Mus musculus (house mouse) ]

    Gene ID: 76894, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Mettl15provided by MGI
    Official Full Name
    methyltransferase like 15provided by MGI
    Primary source
    MGI:MGI:1924144
    See related
    Ensembl:ENSMUSG00000057234 AllianceGenome:MGI:1924144
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mett5d1; 0610027B03Rik
    Summary
    Predicted to enable rRNA (cytosine-N4-)-methyltransferase activity. Predicted to be involved in rRNA base methylation. Predicted to be active in mitochondrial matrix. Is expressed in neocortex. Orthologous to several human genes including METTL15 (methyltransferase 15, mitochondrial 12S rRNA N4-cytidine). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 2.5), liver E14 (RPKM 2.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mettl15 in Genome Data Viewer
    Location:
    2 E3; 2 56.52 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (108922642..109111100, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (109092297..109281330, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta, pseudogene Neighboring gene STARR-seq mESC enhancer starr_05346 Neighboring gene predicted gene 13923 Neighboring gene STARR-seq mESC enhancer starr_05347 Neighboring gene STARR-seq mESC enhancer starr_05348 Neighboring gene STARR-seq mESC enhancer starr_05349 Neighboring gene kinesin family member 18A Neighboring gene STARR-positive B cell enhancer ABC_E5956 Neighboring gene STARR-seq mESC enhancer starr_05353 Neighboring gene STARR-seq mESC enhancer starr_05354 Neighboring gene ribosomal protein L17 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial rRNA Methylation by Mettl15 Contributes to the Exercise and Learning Capability in Mice. Averina OA, et al. Int J Mol Sci, 2022 May 27. PMID 35682734, Free PMC Article
    2. METTL15 interacts with the assembly intermediate of murine mitochondrial small ribosomal subunit to form m4C840 12S rRNA residue. Laptev I, et al. Nucleic Acids Res, 2020 Aug 20. PMID 32573735, Free PMC Article
    3. Distinct, dosage-sensitive requirements for the autism-associated factor CHD8 during cortical development. Hurley S, et al. Mol Autism, 2021 Feb 24. PMID 33627187, Free PMC Article
    4. Analysis of Pax6 contiguous gene deletions in the mouse, Mus musculus, identifies regions distinct from Pax6 responsible for extreme small-eye and belly-spotting phenotypes. Favor J, et al. Genetics, 2009 Aug. PMID 19474196, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mitochondrial rRNA Methylation by Mettl15 Contributes to the Exercise and Learning Capability in Mice.
      Title: Mitochondrial rRNA Methylation by Mettl15 Contributes to the Exercise and Learning Capability in Mice.
    2. METTL15 interacts with the assembly intermediate of murine mitochondrial small ribosomal subunit to form m4C840 12S rRNA residue.
      Title: METTL15 interacts with the assembly intermediate of murine mitochondrial small ribosomal subunit to form m4C840 12S rRNA residue.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC118452

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables rRNA (cytosine-N4-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA (cytosine-N4-)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA (cytosine-N4-)-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in rRNA base methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA base methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    12S rRNA N4-methylcytidine methyltransferase
    Names
    12S rRNA m4C methyltransferase
    methyltransferase 5 domain containing 1
    methyltransferase 5 domain-containing protein 1
    methyltransferase-like protein 15
    probable S-adenosyl-L-methionine-dependent methyltransferase METT5D1
    probable methyltransferase-like protein 15
    putative S-adenosyl-L-methionine-dependent methyltransferase METT5D1
    NP_001405755.1
    NP_001405756.1
    NP_001405757.1
    NP_001405758.1
    NP_001405759.1
    NP_001405760.1
    NP_001405761.1
    NP_001405762.1
    NP_084066.2
    XP_036018578.1
    XP_036018579.1
    XP_036018580.1
    XP_036018581.1
    XP_036018582.1
    XP_036018583.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418826.1 → NP_001405755.1  12S rRNA N4-methylcytidine methyltransferase isoform a

      Status: VALIDATED

      Source sequence(s)
      AL691430, BX813309, BX813328
      UniProtKB/Swiss-Prot
      Q3KQI4, Q9DCL4

    2. NM_001418827.1 → NP_001405756.1  12S rRNA N4-methylcytidine methyltransferase isoform a

      Status: VALIDATED

      Source sequence(s)
      AL691430, BX813309, BX813328
      UniProtKB/Swiss-Prot
      Q3KQI4, Q9DCL4

    3. NM_001418828.1 → NP_001405757.1  12S rRNA N4-methylcytidine methyltransferase isoform a

      Status: VALIDATED

      Source sequence(s)
      AL691430, BX813309, BX813328
      UniProtKB/Swiss-Prot
      Q3KQI4, Q9DCL4

    4. NM_001418829.1 → NP_001405758.1  12S rRNA N4-methylcytidine methyltransferase isoform b

      Status: VALIDATED

      Source sequence(s)
      AL691430, BX813309, BX813328
      Related
      ENSMUSP00000116829.2, ENSMUST00000147770.2

    5. NM_001418830.1 → NP_001405759.1  12S rRNA N4-methylcytidine methyltransferase isoform b

      Status: VALIDATED

      Source sequence(s)
      AL691430, BX813309, BX813328

    6. NM_001418831.1 → NP_001405760.1  12S rRNA N4-methylcytidine methyltransferase isoform b

      Status: VALIDATED

      Source sequence(s)
      AL691430, BX813309, BX813328

    7. NM_001418832.1 → NP_001405761.1  12S rRNA N4-methylcytidine methyltransferase isoform b

      Status: VALIDATED

      Source sequence(s)
      AL691430, BX813309, BX813328

    8. NM_001418833.1 → NP_001405762.1  12S rRNA N4-methylcytidine methyltransferase isoform c

      Status: VALIDATED

      Source sequence(s)
      AL691430, BX813309

    9. NM_029790.4 → NP_084066.2  12S rRNA N4-methylcytidine methyltransferase isoform a

      See identical proteins and their annotated locations for NP_084066.2

      Status: VALIDATED

      Source sequence(s)
      AL691430, BX813309, BX813328
      Consensus CDS
      CCDS16506.1
      UniProtKB/Swiss-Prot
      Q3KQI4, Q9DCL4
      Related
      ENSMUSP00000080337.4, ENSMUST00000081631.10
      Conserved Domains (1) summary
      PRK00050
      Location:72 → 406
      PRK00050; 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH

    RNA

    1. NR_184831.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL691430, BX813309, BX813328

    2. NR_184832.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL691430, BX813309, BX813328

    3. NR_184833.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL691430, BX813309, BX813328

    4. NR_184834.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL691430, BX813309, BX813328
      Related
      ENSMUST00000147376.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      108922642..109111100 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162689.1 → XP_036018582.1  12S rRNA N4-methylcytidine methyltransferase isoform X3

      Conserved Domains (1) summary
      cl17173
      Location:8 → 253
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. XM_036162688.1 → XP_036018581.1  12S rRNA N4-methylcytidine methyltransferase isoform X2

      Conserved Domains (1) summary
      cl17173
      Location:2 → 312
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    3. XM_036162690.1 → XP_036018583.1  12S rRNA N4-methylcytidine methyltransferase isoform X3

      Conserved Domains (1) summary
      cl17173
      Location:8 → 253
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    4. XM_036162685.1 → XP_036018578.1  12S rRNA N4-methylcytidine methyltransferase isoform X2

      Conserved Domains (1) summary
      cl17173
      Location:2 → 312
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    5. XM_036162686.1 → XP_036018579.1  12S rRNA N4-methylcytidine methyltransferase isoform X2

      Conserved Domains (1) summary
      cl17173
      Location:2 → 312
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    6. XM_036162687.1 → XP_036018580.1  12S rRNA N4-methylcytidine methyltransferase isoform X2

      Conserved Domains (1) summary
      cl17173
      Location:2 → 312
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DCL4.2 GenPept UniProtKB/Swiss-Prot:Q9DCL4

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