Ppp1r11 protein phosphatase 1, regulatory inhibitor subunit 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppp1r11provided by MGI
Official Full Name: protein phosphatase 1, regulatory inhibitor subunit 11provided by MGI
Primary source: MGI:MGI:1923747
See related: Ensembl:ENSMUSG00000036398 AllianceGenome:MGI:1923747
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hcgv; Tcte5; Tctex5; Tctex-5; 1500041B02Rik
Summary: Enables protein phosphatase inhibitor activity. Involved in defense response to Gram-positive bacterium; negative regulation of cytokine production; and ubiquitin-dependent protein catabolic process. Located in cytoplasm. Is expressed in several structures, including central nervous system; gut; hemolymphoid system gland; integumental system; and male reproductive gland or organ. Orthologous to human PPP1R11 (protein phosphatase 1 regulatory inhibitor subunit 11). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Broad expression in testis adult (RPKM 131.5), CNS E14 (RPKM 20.0) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 19.16 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (37259247..37262684, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (36948355..36951792, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The three regulators (PPP1R2, PPP1R7, and PPP1R11)share localization with PP1gamma2 in the head and the principal piece of sperm. We show that the association of inhibitors to PP1gamma2 changes during epididymal sperm maturation. In immotile caput epididymal sperm, PPP1R2 and PPP1R7 are not bound to PP1gamma2, whereas in motile caudal sperm, all three inhibitors are bound as heterodimers or heterotrimers.
Title: Regulators of the protein phosphatase PP1γ2, PPP1R2, PPP1R7, and PPP1R11 are involved in epididymal sperm maturation.
Lentiviral gene transfer or knockdown of PPP1R11 in mouse lungs significantly affects lung inflammation and the clearance of Staphylococcus aureus. There is a negative correlation between PPP1R11 and TLR2 levels in white blood cell samples isolated from patients with Staphylococcus aureus infections.
Title: RING finger E3 ligase PPP1R11 regulates TLR2 signaling and innate immunity.
Data show a reciprocal relationship between protein phosphatase isoform PP1gamma2 and its regulator PPP1R11, and suggest that complex formation between them in testis may prevent proteolysis of PPP1R11 and germ cell apoptosis.
Title: PP1gamma2 and PPP1R11 are parts of a multimeric complex in developing testicular germ cells in which their steady state levels are reciprocally related.
Tctex5 might be a specific protein phosphatase-1 inhibitor in sperm; various Tctex5 transcripts and isoforms and cellular locations imply its different roles in spermatogenesis.
Title: Expression of a novel T-complex testis expressed 5 (Tctex5) in mouse testis, epididymis, and spermatozoa.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ppp1r11 (e-PCR), detects polymorphism
- UniSTS:507940

RH131842 (e-PCR)
- UniSTS:215125

Tctex5 (e-PCR), detects polymorphism
- UniSTS:144583

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase 1 binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein phosphatase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine phosphatase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase PPP1R11

Names: T-complex testis expressed protein 5; protein phosphatase 1 regulatory subunit 11; t-complex testis-expressed 5

NP_083908.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.