Tia1 cytotoxic granule-associated RNA binding protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tia1provided by MGI
Official Full Name: cytotoxic granule-associated RNA binding protein 1provided by MGI
Primary source: MGI:MGI:107914
See related: Ensembl:ENSMUSG00000071337 AllianceGenome:MGI:107914
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TIA-1; mTIA-1; 2310050N03Rik
Summary: Enables mRNA 3'-UTR AU-rich region binding activity. Involved in negative regulation of translation and regulation of alternative mRNA splicing, via spliceosome. Acts upstream of or within negative regulation of cytokine production. Located in cytoplasmic stress granule and nuclear stress granule. Is expressed in several structures, including alimentary system; brain; metanephros; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 26. Orthologous to human TIA1 (TIA1 cytotoxic granule associated RNA binding protein). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Broad expression in CNS E14 (RPKM 41.1), whole brain E14.5 (RPKM 40.1) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 D1; 6 37.69 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (86381001..86410387)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (86404203..86433405)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The RNA binding proteins TIA1 and TIAL1 promote Mcl1 mRNA translation to protect germinal center responses from apoptosis.
Title: The RNA binding proteins TIA1 and TIAL1 promote Mcl1 mRNA translation to protect germinal center responses from apoptosis.
Dynamics of alternative splicing during somatic cell reprogramming reveals functions for RNA-binding proteins CPSF3, hnRNP UL1, and TIA1.
Title: Dynamics of alternative splicing during somatic cell reprogramming reveals functions for RNA-binding proteins CPSF3, hnRNP UL1, and TIA1.
Deficiency of T-Cell Intracellular Antigen 1 in Murine Embryonic Fibroblasts Is Associated with Changes in Mitochondrial Morphology and Respiration.
Title: Deficiency of T-Cell Intracellular Antigen 1 in Murine Embryonic Fibroblasts Is Associated with Changes in Mitochondrial Morphology and Respiration.
Micellar TIA1 with folded RNA binding domains as a model for reversible stress granule formation.
Title: Micellar TIA1 with folded RNA binding domains as a model for reversible stress granule formation.
Overexpression of TIA1 in the ventral hippocampus inhibits fear memory in males and females. Deletion of TIA1 modulates odor avoidance behavior in female mice only.
Title: Genetic Perturbation of TIA1 Reveals a Physiological Role in Fear Memory.
that TIA1 reduction essentially brackets the pathophysiology of tau
Title: TIA1 regulates the generation and response to toxic tau oligomers.
These data provide in vivo evidence that TIA1 plays a key role in mediating toxicity and further suggest that RNA binding proteins direct the pathway of tau aggregation and the resulting neurodegeneration
Title: Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo.
Results demonstrate that neither the basal nor seizure-induced expression profiles of COX-2 were altered in mice lacking a functional TIA-1 gene suggesting that TIA-1 does not contribute to regulation of COX-2 protein expression in neurons. Induced seizure threshold was also unchanged in mice lacking TIA-1 protein, indicating that this RNA binding protein does not influence the innate seizure threshold.
Title: Maintenance of the Innate Seizure Threshold by Cyclooxygenase-2 is Not Influenced by the Translational Silencer, T-cell Intracellular Antigen-1.
Tia1 controls p53 mRNA translation in B cells.
Title: Tia1 dependent regulation of mRNA subcellular location and translation controls p53 expression in B cells.
TIA1 knockdown or knockout inhibits tau misfolding and associated toxicity in cultured hippocampal neurons, while overexpressing TIA1 induces tau misfolding and stimulates neurodegeneration.
Title: Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tia1 (e-PCR), detects polymorphism
- UniSTS:479294

RH136064 (e-PCR)
- UniSTS:210059

Tia1 (e-PCR), detects polymorphism
- UniSTS:507387

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR AU-rich region binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of translation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of epithelial cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epithelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cytoplasmic stress granule	IEA Inferred from Electronic Annotation more info
involved_in protein localization to cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
involved_in regulation of alternative mRNA splicing, via spliceosome	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of alternative mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in stress granule assembly	ISO Inferred from Sequence Orthology more info
involved_in stress granule assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear stress granule	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear stress granule	ISO Inferred from Sequence Orthology more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytotoxic granule associated RNA binding protein TIA1

Names: RNA-binding protein TIA-1; T-cell-restricted intracellular antigen-1; nucleolysin TIA-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164078.1 → NP_001157550.1 cytotoxic granule associated RNA binding protein TIA1 isoform 2

See identical proteins and their annotated locations for NP_001157550.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region and lacks an alternate in-frame exon in the central coding region compared to variant 1. The resulting isoform (2) includes a two-aa segment and lacks a second internal segment, compared to isoform 1.

Source sequence(s)

AC153374, BC046812

Consensus CDS

CCDS51834.1

UniProtKB/TrEMBL

D3Z4H6, Q80ZW7

Related

ENSMUSP00000109342.3, ENSMUST00000113713.9

Conserved Domains (4) summary

cd12618
Location:96 → 175

RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins

cd12621
Location:205 → 278

RRM3_TIA1; RNA recognition motif 3 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins

TIGR01661
Location:6 → 271

ELAV_HUD_SF; ELAV/HuD family splicing factor

cl17169
Location:8 → 83

RRM_SF; RNA recognition motif (RRM) superfamily
NM_001164079.1 → NP_001157551.1 cytotoxic granule associated RNA binding protein TIA1 isoform 3

See identical proteins and their annotated locations for NP_001157551.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks three alternate in-frame exons, compared to variant 1. The resulting isoform (3) lacks two internal segments, compared to isoform 1.

Source sequence(s)

AC153374

Consensus CDS

CCDS51833.1

UniProtKB/TrEMBL

Q8CII5

Related

ENSMUSP00000118558.2, ENSMUST00000130967.8

Conserved Domains (2) summary

cd12618
Location:94 → 173

RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins

cl17169
Location:8 → 81

RRM_SF; RNA recognition motif (RRM) superfamily
NM_011585.4 → NP_035715.1 cytotoxic granule associated RNA binding protein TIA1 isoform 1

See identical proteins and their annotated locations for NP_035715.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC153374, U55862

Consensus CDS

CCDS20312.1

UniProtKB/Swiss-Prot

P52912

UniProtKB/TrEMBL

D3Z4H6, Q564E7

Related

ENSMUSP00000093425.3, ENSMUST00000095753.9

Conserved Domains (4) summary

cd12615
Location:8 → 81

RRM1_TIA1; RNA recognition motif 1 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins

cd12618
Location:105 → 184

RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins

cd12621
Location:214 → 287

RRM3_TIA1; RNA recognition motif 3 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins

TIGR01661
Location:6 → 280

ELAV_HUD_SF; ELAV/HuD family splicing factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

86381001..86410387

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006505891.4 → XP_006505954.1 cytotoxic granule associated RNA binding protein TIA1 isoform X3

Conserved Domains (3) summary

cd12615
Location:8 → 81

RRM1_TIA1; RNA recognition motif 1 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins

cd12618
Location:105 → 184

RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins

cl17169
Location:214 → 255

RRM_SF; RNA recognition motif (RRM) superfamily
XM_017321512.3 → XP_017177001.1 cytotoxic granule associated RNA binding protein TIA1 isoform X2

Conserved Domains (3) summary

cd12618
Location:105 → 184

RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins

cd12621
Location:214 → 287

RRM3_TIA1; RNA recognition motif 3 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins

cl17169
Location:8 → 81

RRM_SF; RNA recognition motif (RRM) superfamily
XM_006505889.4 → XP_006505952.1 cytotoxic granule associated RNA binding protein TIA1 isoform X1

See identical proteins and their annotated locations for XP_006505952.1

UniProtKB/TrEMBL

D3Z4H6, G5E8L2

Related

ENSMUSP00000093424.3, ENSMUST00000095752.9

Conserved Domains (3) summary

cd12618
Location:94 → 173

RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins

cd12621
Location:203 → 276

RRM3_TIA1; RNA recognition motif 3 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins

cl17169
Location:8 → 81

RRM_SF; RNA recognition motif (RRM) superfamily
XM_017321513.3 → XP_017177002.1 cytotoxic granule associated RNA binding protein TIA1 isoform X5

Conserved Domains (3) summary

TIGR01628
Location:4 → 239

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12620
Location:74 → 146

RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins

cl17169
Location:1 → 41

RRM_SF; RNA recognition motif (RRM) superfamily
XM_036166017.1 → XP_036021910.1 cytotoxic granule associated RNA binding protein TIA1 isoform X5

Conserved Domains (3) summary

TIGR01628
Location:4 → 239

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12620
Location:74 → 146

RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins

cl17169
Location:1 → 41

RRM_SF; RNA recognition motif (RRM) superfamily
XM_036166018.1 → XP_036021911.1 cytotoxic granule associated RNA binding protein TIA1 isoform X5

Conserved Domains (3) summary

TIGR01628
Location:4 → 239

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12620
Location:74 → 146

RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins

cl17169
Location:1 → 41

RRM_SF; RNA recognition motif (RRM) superfamily
XM_036166016.1 → XP_036021909.1 cytotoxic granule associated RNA binding protein TIA1 isoform X4

Conserved Domains (2) summary

cd12620
Location:113 → 185

RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins

cd12353
Location:6 → 80

RRM2_TIA1_like; RNA recognition motif 2 (RRM2) found in granule-associated RNA binding proteins p40-TIA-1 and TIAR
XM_036166020.1 → XP_036021913.1 cytotoxic granule associated RNA binding protein TIA1 isoform X6

Conserved Domains (2) summary

cd12618
Location:3 → 80

RRM2_TIA1; RNA recognition motif 2 (RRM2) found in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins

cl17169
Location:113 → 154

RRM_SF; RNA recognition motif (RRM) superfamily
XM_006505893.5 → XP_006505956.1 cytotoxic granule associated RNA binding protein TIA1 isoform X5

See identical proteins and their annotated locations for XP_006505956.1

Conserved Domains (3) summary

TIGR01628
Location:4 → 239

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12620
Location:74 → 146

RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins

cl17169
Location:1 → 41

RRM_SF; RNA recognition motif (RRM) superfamily
XM_011241285.4 → XP_011239587.1 cytotoxic granule associated RNA binding protein TIA1 isoform X4

Conserved Domains (2) summary

cd12620
Location:113 → 185

RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins

cd12353
Location:6 → 80

RRM2_TIA1_like; RNA recognition motif 2 (RRM2) found in granule-associated RNA binding proteins p40-TIA-1 and TIAR
XM_030255313.1 → XP_030111173.1 cytotoxic granule associated RNA binding protein TIA1 isoform X5

Conserved Domains (3) summary

TIGR01628
Location:4 → 239

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12620
Location:74 → 146

RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins

cl17169
Location:1 → 41

RRM_SF; RNA recognition motif (RRM) superfamily
XM_036166019.1 → XP_036021912.1 cytotoxic granule associated RNA binding protein TIA1 isoform X5

Conserved Domains (3) summary

TIGR01628
Location:4 → 239

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12620
Location:74 → 146

RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins

cl17169
Location:1 → 41

RRM_SF; RNA recognition motif (RRM) superfamily