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    Psors1c2 psoriasis susceptibility 1 candidate 2 (human) [ Mus musculus (house mouse) ]

    Gene ID: 57390, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Psors1c2provided by MGI
    Official Full Name
    psoriasis susceptibility 1 candidate 2 (human)provided by MGI
    Primary source
    MGI:MGI:1930025
    See related
    Ensembl:ENSMUSG00000024409 AllianceGenome:MGI:1930025
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pcg; SPR1
    Summary
    Predicted to be located in extracellular region. Orthologous to human PSORS1C2 (psoriasis susceptibility 1 candidate 2). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in stomach adult (RPKM 7.3), thymus adult (RPKM 2.9) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Psors1c2 in Genome Data Viewer
    Location:
    17 B1; 17 18.7 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35842462..35845544)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35533201..35534647)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr17:35653747-35654048 Neighboring gene transcription factor 19 Neighboring gene coiled-coil alpha-helical rod protein 1 Neighboring gene STARR-seq mESC enhancer starr_42461 Neighboring gene corneodesmosin Neighboring gene translation machinery-associated protein 7-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Small proline-rich protein 1A is a gp130 pathway- and stress-inducible cardioprotective protein. Pradervand S, et al. EMBO J, 2004 Nov 10. PMID 15510217, Free PMC Article
    2. Polymorphisms in the SEEK1 and SPR1 genes on 6p21.3 associate with psoriasis in the Swedish population. Holm SJ, et al. Exp Dermatol, 2003 Aug. PMID 12930300
    3. Identification of candidate lung cancer susceptibility genes in mouse using oligonucleotide arrays. Lemon WJ, et al. J Med Genet, 2002 Sep. PMID 12205107, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. spr1 is a gp130 pathway- and stress-inducible cardioprotective protein.
      Title: Small proline-rich protein 1A is a gp130 pathway- and stress-inducible cardioprotective protein.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    psoriasis susceptibility 1 candidate gene 2 protein homolog
    Names
    MHC psoriasis candidate

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020576.2 → NP_065601.2  psoriasis susceptibility 1 candidate gene 2 protein homolog precursor

      See identical proteins and their annotated locations for NP_065601.2

      Status: VALIDATED

      Source sequence(s)
      AF484421, AK137759
      Consensus CDS
      CCDS50091.1
      UniProtKB/Swiss-Prot
      Q80ZC9
      UniProtKB/TrEMBL
      Q3UUY0
      Related
      ENSMUSP00000025273.9, ENSMUST00000025273.9
      Conserved Domains (1) summary
      pfam15356
      Location:23 → 135
      SPR1; Psoriasis susceptibility locus 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      35842462..35845544
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160707.1 → XP_036016600.1  psoriasis susceptibility 1 candidate gene 2 protein homolog isoform X1

      UniProtKB/Swiss-Prot
      Q80ZC9
      UniProtKB/TrEMBL
      Q3UUY0
      Conserved Domains (1) summary
      pfam15356
      Location:23 → 135
      SPR1; Psoriasis susceptibility locus 2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80ZC9.1 GenPept UniProtKB/Swiss-Prot:Q80ZC9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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