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    Dhx9 DExH-box helicase 9 [ Mus musculus (house mouse) ]

    Gene ID: 13211, updated on 28-Oct-2024

    Summary

    Official Symbol
    Dhx9provided by MGI
    Official Full Name
    DExH-box helicase 9provided by MGI
    Primary source
    MGI:MGI:108177
    See related
    Ensembl:ENSMUSG00000042699 AllianceGenome:MGI:108177
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RHA; Ddx9; HEL-5; NDHII; mHEL-5
    Summary
    Enables regulatory region RNA binding activity. Involved in positive regulation of interleukin-18 production; pyroptotic inflammatory response; and regulation of defense response. Acts upstream of or within cellular response to heat and circadian rhythm. Located in nucleolus. Is expressed in several structures, including alimentary system; central nervous system; lung; salivary gland primordium; and sensory organ. Orthologous to human DHX9 (DExH-box helicase 9). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 71.6), CNS E14 (RPKM 55.5) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Dhx9 in Genome Data Viewer
    Location:
    1 G3; 1 65.37 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (153331506..153363464, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (153455756..153487688, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene Riken cDNA E330020D12 gene Neighboring gene STARR-positive B cell enhancer ABC_E5821 Neighboring gene STARR-positive B cell enhancer ABC_E5822 Neighboring gene Shc SH2-domain binding protein 1-like Neighboring gene predicted gene, 25588 Neighboring gene STARR-positive B cell enhancer mm9_chr1:155334650-155334951 Neighboring gene STARR-positive B cell enhancer ABC_E7758 Neighboring gene STARR-seq mESC enhancer starr_02698 Neighboring gene STARR-seq mESC enhancer starr_02701 Neighboring gene N-acetylneuraminate pyruvate lyase Neighboring gene STARR-seq mESC enhancer starr_02703 Neighboring gene STARR-seq mESC enhancer starr_02704 Neighboring gene STARR-seq mESC enhancer starr_02705 Neighboring gene predicted gene 6652

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC90954

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 3'-5' DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 3'-5' DNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables 3'-5' DNA/RNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 3'-5' DNA/RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables 3'-5' RNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 3'-5' RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP hydrolysis activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables DNA replication origin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA replication origin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables RISC complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RISC complex binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables RNA polymerase II complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables RNA stem-loop binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA stem-loop binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables chromatin DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables importin-alpha family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables importin-alpha family protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleoside triphosphate diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleoside triphosphate diphosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables promoter-specific chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables promoter-specific chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables regulatory region RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables regulatory region RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribonucleoside triphosphate phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ribosome binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables siRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded 3'-5' DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded 3'-5' DNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables single-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transcription coregulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables triplex DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables triplex DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in CRD-mediated mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA duplex unwinding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA duplex unwinding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in DNA-templated transcription termination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA-templated viral transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in G-quadruplex DNA unwinding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in G-quadruplex DNA unwinding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in RISC complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in RISC complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in RNA secondary structure unwinding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in RNA secondary structure unwinding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in alternative mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to exogenous dsRNA ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to exogenous dsRNA ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within cellular response to heat IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to tumor necrosis factor ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in miRNA-mediated post-transcriptional gene silencing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in miRNA-mediated post-transcriptional gene silencing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA repair ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA replication ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of RNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of RNA export from nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cytoplasmic translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytoplasmic translation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of fibroblast proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interferon-alpha production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interferon-alpha production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interferon-beta production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interferon-beta production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interleukin-18 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-6 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of response to cytokine stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of response to cytokine stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of tumor necrosis factor production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of viral transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pyroptotic inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cytoplasmic translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cytoplasmic translation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of defense response to virus by host IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of mRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of mRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of CRD-mediated mRNA stability complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of CRD-mediated mRNA stability complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of RISC complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of RISC complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of RISC-loading complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of RISC-loading complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in actin cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic ribonucleoprotein granule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nuclear stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear stress granule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perichromatin fibrils ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perichromatin fibrils ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    ATP-dependent RNA helicase A
    Names
    D-E-A-D (aspartate-glutamate-alanine-aspartate) box polypeptide 9
    DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 9
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 9
    DEAH (Asp-Glu-Ala-His) box polypeptide 9
    DEAH box protein 9
    RNA helicase A
    leukophysin
    nuclear DNA helicase II
    NP_001392438.1
    NP_031868.2
    XP_030102263.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001405509.1NP_001392438.1  ATP-dependent RNA helicase A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC098709, AC099712
      UniProtKB/TrEMBL
      E9QNN1
      Related
      ENSMUSP00000038135.6, ENSMUST00000042141.12
    2. NM_007842.3NP_031868.2  ATP-dependent RNA helicase A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC098709, AC099712
      Consensus CDS
      CCDS78706.1
      UniProtKB/Swiss-Prot
      O35931, O54703, O70133, Q5FWY1, Q6R5F7, Q9CSA2
      UniProtKB/TrEMBL
      A0A087WPL5
      Related
      ENSMUSP00000139825.2, ENSMUST00000186380.7
      Conserved Domains (6) summary
      smart00358
      Location:569
      DSRM; Double-stranded RNA binding motif
      smart00847
      Location:840921
      HA2; Helicase associated domain (HA2) Add an annotation
      COG1643
      Location:3361054
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd00046
      Location:407548
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00271
      Location:637770
      Helicase_C; Helicase conserved C-terminal domain
      pfam07717
      Location:9611075
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

    RNA

    1. NR_175951.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC098709, AC099712
    2. NR_175952.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC098709, AC099712

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      153331506..153363464 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246403.2XP_030102263.1  ATP-dependent RNA helicase A isoform X2

      UniProtKB/Swiss-Prot
      O35931, O54703, O70133, Q5FWY1, Q6R5F7, Q9CSA2
      Conserved Domains (3) summary
      COG1643
      Location:120838
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd17972
      Location:116349
      DEXHc_DHX9; DEXH-box helicase domain of DEAH-box helicase 9
      cd19855
      Location:138
      DSRM_DHX9_rpt2; second double-stranded RNA binding motif of DEAH box protein 9 (DHX9) and similar proteins