Mkrn3 makorin, ring finger protein, 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mkrn3provided by MGI
Official Full Name: makorin, ring finger protein, 3provided by MGI
Primary source: MGI:MGI:2181178
See related: Ensembl:ENSMUSG00000070527 AllianceGenome:MGI:2181178
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Zfp127; D7H15S9-1
Summary: Predicted to enable identical protein binding activity and ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Is expressed in gut; nervous system; and sensory organ. Used to study central precocious puberty 2. Human ortholog(s) of this gene implicated in central precocious puberty 2. Orthologous to human MKRN3 (makorin ring finger protein 3). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: human all
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Genomic context

Location:: 7 C; 7 34.37 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (62067341..62069901, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (62417593..62420153, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mouse Testicular Mkrn3 Expression Is Primarily Interstitial, Increases Peripubertally, and Is Responsive to LH/hCG.
Title: Mouse Testicular Mkrn3 Expression Is Primarily Interstitial, Increases Peripubertally, and Is Responsive to LH/hCG.
MKRN3 inhibits puberty onset via interaction with IGF2BP1 and regulation of hypothalamic plasticity.
Title: MKRN3 inhibits puberty onset via interaction with IGF2BP1 and regulation of hypothalamic plasticity.
Methylation status of hypothalamic Mkrn3 promoter across puberty.
Title: Methylation status of hypothalamic Mkrn3 promoter across puberty.
Hypothalamic Overexpression of Makorin Ring Finger Protein 3 Results in Delayed Puberty in Female Mice.
Title: Hypothalamic Overexpression of Makorin Ring Finger Protein 3 Results in Delayed Puberty in Female Mice.
E3 ligase MKRN3 is a tumor suppressor regulating PABPC1 ubiquitination in non-small cell lung cancer.
Title: E3 ligase MKRN3 is a tumor suppressor regulating PABPC1 ubiquitination in non-small cell lung cancer.
MKRN3 inhibits the reproductive axis through actions in kisspeptin-expressing neurons.
Title: MKRN3 inhibits the reproductive axis through actions in kisspeptin-expressing neurons.
Zfp127 is a novel regulator of Oct4, and may become a potent target to improve cellular reprogramming.
Title: Imprinted gene Zinc finger protein 127 is a novel regulator of master pluripotency transcription factor, Oct4.
Mkrn3, encoding a RING zinc-finger protein, is imprinted, with preferential expression from the paternal allele.
Title: Imprinting of a RING zinc-finger encoding gene in the mouse chromosome region homologous to the Prader-Willi syndrome genetic region.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BB418144 (e-PCR)
- UniSTS:208138

Mkrn3 (e-PCR), detects polymorphism
- UniSTS:547456

U19106 (e-PCR)
- UniSTS:159649

NoName (e-PCR)
- UniSTS:532147

Mkrn3 (e-PCR), detects polymorphism
- UniSTS:532147

Zfp127 (e-PCR), detects polymorphism
- UniSTS:144820

PMC218737P2 (e-PCR)
- UniSTS:272076

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein polyubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: probable E3 ubiquitin-protein ligase makorin-3

Names: RING-type E3 ubiquitin transferase makorin-3; zinc finger protein 127

NP_035876.2

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011746.3 → NP_035876.2 probable E3 ubiquitin-protein ligase makorin-3

See identical proteins and their annotated locations for NP_035876.2

Status: VALIDATED

Source sequence(s)

AC156555

Consensus CDS

CCDS21327.1

UniProtKB/Swiss-Prot

Q3UY92, Q60764, Q7TQE4

Related

ENSMUSP00000091898.4, ENSMUST00000094340.4

Conserved Domains (3) summary

smart00356
Location:92 → 118

ZnF_C3H1; zinc finger

cd00162
Location:347 → 401

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

pfam15815
Location:467 → 542

MKRN1_C; E3 ubiquitin-protein ligase makorin-1, C-terminal