Cant1 calcium activated nucleotidase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cant1provided by MGI
Official Full Name: calcium activated nucleotidase 1provided by MGI
Primary source: MGI:MGI:1923275
See related: Ensembl:ENSMUSG00000025575 AllianceGenome:MGI:1923275
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Apy1h; Shapy; Entpd8; SCAN-1; D11Bwg0554e; 5830420C20Rik
Summary: The protein encoded by this gene is a calcium-dependent nucleotidase that preferentially hydrolyzes UDP, GDP, and IDP. The encoded protein has low activity with ADP and ATP and shows no activity with AMP and GMP. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
Expression: Ubiquitous expression in colon adult (RPKM 53.2), duodenum adult (RPKM 33.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 83.15 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (118297115..118309971, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (118406289..118419134, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Circ_0001715 accelerated lung adenocarcinoma process by the miR-1322/CANT1 axis.
Title: Circ_0001715 accelerated lung adenocarcinoma process by the miR-1322/CANT1 axis.
Phenotypic Characterization of Immortalized Chondrocytes from a Desbuquois Dysplasia Type 1 Mouse Model: A Tool for Studying Defects in Glycosaminoglycan Biosynthesis.
Title: Phenotypic Characterization of Immortalized Chondrocytes from a Desbuquois Dysplasia Type 1 Mouse Model: A Tool for Studying Defects in Glycosaminoglycan Biosynthesis.
CANT1 deficiency in a mouse model of Desbuquois dysplasia impairs glycosaminoglycan synthesis and chondrocyte differentiation in growth plate cartilage.
Title: CANT1 deficiency in a mouse model of Desbuquois dysplasia impairs glycosaminoglycan synthesis and chondrocyte differentiation in growth plate cartilage.
To understanding the mechanism of CANT1 mutations in Desbuquois dysplasia type 1, a novel Cant1 knock-in and knock-out murine strains were developed. Both strains present with a skeletal and connective tissue phenotype recapitulating human DBQD1. Cartilage samples and primary chondrocytes demonstrate that CANT1 defects not only affect GAG synthesis, but also GAG elongation, sulfation and PG secretion.
Title: Calcium activated nucleotidase 1 (CANT1) is critical for glycosaminoglycan biosynthesis in cartilage and endochondral ossification.
CANT1 long non-coding RNA triggers efficient therapeutic efficacy by correcting aberrant long non-coding cascade in malignant uveal melanoma.
Title: CANT1 lncRNA Triggers Efficient Therapeutic Efficacy by Correcting Aberrant lncing Cascade in Malignant Uveal Melanoma.
Restoring CANT1 levels in neuroblastoma clones recovered the phenotype, thus confirming a key role of CANT1, and of the regulation of its gene by DREAM, in the control of protein synthesis and degradation
Title: Ca2+-activated nucleotidase 1, a novel target gene for the transcriptional repressor DREAM (downstream regulatory element antagonist modulator), is involved in protein folding and degradation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (5) 1 citation

General gene information

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Markers

D11Bwg0554e (e-PCR), detects polymorphism
- UniSTS:141720

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ADP phosphatase activity	IEA Inferred from Electronic Annotation more info
enables ADP phosphatase activity	ISO Inferred from Sequence Orthology more info
enables GDP phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GDP phosphatase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables UDP phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables UDP phosphatase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in proteoglycan biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteoglycan biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in proteoglycan biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within ribonucleoside diphosphate catabolic process	IC Inferred by Curator more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi cisterna membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: soluble calcium-activated nucleotidase 1

Names: Ca2+-dependent endoplasmic reticulum nucleoside diphosphatase; apyrase 1, homolog (C. lectularius); apyrase homolog

NP_001020788.1

EC 3.6.1.6

NP_001020789.1

EC 3.6.1.6

NP_001254520.1

EC 3.6.1.6

NP_001254521.1

EC 3.6.1.6

NP_083778.2

EC 3.6.1.6

XP_006534467.1

EC 3.6.1.6

XP_006534468.1

EC 3.6.1.6

XP_006534469.1

EC 3.6.1.6

XP_006534470.1

EC 3.6.1.6

XP_006534471.1

EC 3.6.1.6

XP_006534472.1

EC 3.6.1.6

XP_006534473.1

EC 3.6.1.6

XP_030102267.1

EC 3.6.1.6

XP_030102268.1

EC 3.6.1.6

XP_030102269.1

EC 3.6.1.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025617.2 → NP_001020788.1 soluble calcium-activated nucleotidase 1 isoform a

See identical proteins and their annotated locations for NP_001020788.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 all encode the same isoform (a).

Source sequence(s)

AK081118, AL591075, AL591404, BF465199, CD562087

Consensus CDS

CCDS25702.1

UniProtKB/Swiss-Prot

B1AQJ8, Q8C3R8, Q8C4T6, Q8VCF1, Q9D3F2, Q9D9R1

Related

ENSMUSP00000101895.2, ENSMUST00000106288.8

Conserved Domains (1) summary

pfam06079
Location:115 → 402

Apyrase
NM_001025618.2 → NP_001020789.1 soluble calcium-activated nucleotidase 1 isoform a

See identical proteins and their annotated locations for NP_001020789.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 all encode the same isoform (a).

Source sequence(s)

AK049879, AL591075, AL591404, BF465199

Consensus CDS

CCDS25702.1

UniProtKB/Swiss-Prot

B1AQJ8, Q8C3R8, Q8C4T6, Q8VCF1, Q9D3F2, Q9D9R1

Related

ENSMUSP00000101894.2, ENSMUST00000106287.8

Conserved Domains (1) summary

pfam06079
Location:115 → 402

Apyrase
NM_001267591.1 → NP_001254520.1 soluble calcium-activated nucleotidase 1 isoform a

See identical proteins and their annotated locations for NP_001254520.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 all encode the same isoform (a).

Source sequence(s)

AK049879, AL591404, BF465199

Consensus CDS

CCDS25702.1

UniProtKB/Swiss-Prot

B1AQJ8, Q8C3R8, Q8C4T6, Q8VCF1, Q9D3F2, Q9D9R1

Related

ENSMUSP00000126919.2, ENSMUST00000164927.2

Conserved Domains (1) summary

pfam06079
Location:115 → 402

Apyrase
NM_001267592.1 → NP_001254521.1 soluble calcium-activated nucleotidase 1 isoform b

See identical proteins and their annotated locations for NP_001254521.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and contains an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is longer compared to isoform a.

Source sequence(s)

AK006565, AL591075, AL591404, BF465199

Consensus CDS

CCDS59572.1

UniProtKB/Swiss-Prot

Q8VCF1

Related

ENSMUSP00000101896.3, ENSMUST00000106289.9

Conserved Domains (1) summary

pfam06079
Location:115 → 439

Apyrase
NM_029502.3 → NP_083778.2 soluble calcium-activated nucleotidase 1 isoform a

See identical proteins and their annotated locations for NP_083778.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a. Variants 1, 2, 3, and 4 all encode the same isoform (a).

Source sequence(s)

AK049879, AK081118, AL591075, AL591404, BF465199

Consensus CDS

CCDS25702.1

UniProtKB/Swiss-Prot

B1AQJ8, Q8C3R8, Q8C4T6, Q8VCF1, Q9D3F2, Q9D9R1

Related

ENSMUSP00000090032.4, ENSMUST00000092378.10

Conserved Domains (1) summary

pfam06079
Location:115 → 402

Apyrase