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    Bricd5 BRICHOS domain containing 5 [ Mus musculus (house mouse) ]

    Gene ID: 319259, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Bricd5provided by MGI
    Official Full Name
    BRICHOS domain containing 5provided by MGI
    Primary source
    MGI:MGI:2441766
    See related
    Ensembl:ENSMUSG00000045744 AllianceGenome:MGI:2441766
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9930021D14Rik
    Summary
    Predicted to be involved in regulation of cell population proliferation. Predicted to be active in extracellular space. Orthologous to human BRICD5 (BRICHOS domain containing 5). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 14.1), ovary adult (RPKM 13.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bricd5 in Genome Data Viewer
    Location:
    17 A3.3; 17 12.39 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24692858..24694443)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24473487..24475471)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4833447I15 gene Neighboring gene STARR-positive B cell enhancer ABC_E7497 Neighboring gene STARR-positive B cell enhancer ABC_E5578 Neighboring gene phosphoglycolate phosphatase Neighboring gene MTOR associated protein, LST8 homolog (S. cerevisiae) Neighboring gene STARR-seq mESC enhancer starr_42087 Neighboring gene CASK interacting protein 1 Neighboring gene TNF receptor-associated factor 7 Neighboring gene STARR-positive B cell enhancer ABC_E33 Neighboring gene RAB26, member RAS oncogene family, opposite strand Neighboring gene small nucleolar RNA, C/D box 60

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. An SFTPC BRICHOS mutant links epithelial ER stress and spontaneous lung fibrosis. Katzen J, et al. JCI Insight, 2019 Mar 21. PMID 30721158, Free PMC Article
    2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An SFTPC BRICHOS mutant links epithelial ER stress and spontaneous lung fibrosis.
      Title: An SFTPC BRICHOS mutant links epithelial ER stress and spontaneous lung fibrosis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    BRICHOS domain-containing protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175682.3 → NP_783613.1  BRICHOS domain-containing protein 5

      See identical proteins and their annotated locations for NP_783613.1

      Status: PROVISIONAL

      Source sequence(s)
      AK079437
      Consensus CDS
      CCDS28483.1
      UniProtKB/TrEMBL
      F6RA38, Q4VAG0, Q8BV89
      Related
      ENSMUSP00000059792.4, ENSMUST00000054946.10
      Conserved Domains (1) summary
      smart01039
      Location:44 → 138
      BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      24692858..24694443
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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