Ddx20 DEAD box helicase 20 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ddx20provided by MGI
Official Full Name: DEAD box helicase 20provided by MGI
Primary source: MGI:MGI:1858415
See related: Ensembl:ENSMUSG00000027905 AllianceGenome:MGI:1858415
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: dp103; GEMIN3
Summary: Enables histone deacetylase binding activity and protein-macromolecule adaptor activity. Involved in positive regulation of apoptotic process. Acts upstream of or within negative regulation of transcription by RNA polymerase II; oogenesis; and regulation of steroid biosynthetic process. Part of RNA polymerase II transcription repressor complex. Is expressed in several structures, including brain; branchial arch; genitourinary system; hemolymphoid system; and liver. Orthologous to human DDX20 (DEAD-box helicase 20). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Broad expression in testis adult (RPKM 40.1), ovary adult (RPKM 10.1) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.2; 3 46.43 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (105585586..105595104, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (105678270..105687788, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DDX20 is required for cell-cycle reentry of prospermatogonia and establishment of spermatogonial stem cell pool during testicular development in mice.
Title: DDX20 is required for cell-cycle reentry of prospermatogonia and establishment of spermatogonial stem cell pool during testicular development in mice.
DDX20 positively regulates the interferon pathway to inhibit viral infection.
Title: DDX20 positively regulates the interferon pathway to inhibit viral infection.
Ddx20, DEAD box helicase 20, is essential for the differentiation of oligodendrocyte and maintenance of myelin gene expression.
Title: Ddx20, DEAD box helicase 20, is essential for the differentiation of oligodendrocyte and maintenance of myelin gene expression.
Diverse functions for murine DP103, with an obligatory role during early embryonic development and also in modulation of steroidogenesis.
Title: DEAD-box protein-103 (DP103, Ddx20) is essential for early embryonic development and modulates ovarian morphology and function.
DP103 directly interacts with sumoylated SF-1 and is coupled to transcriptional repression by protein sumoylation.
Title: The DEAD-box protein DP103 (Ddx20 or Gemin-3) represses orphan nuclear receptor activity via SUMO modification.
Ddx20 repressed Egr2-mediated transcriptional activation with significant promoter specificity
Title: The Ddx20/DP103 dead box protein represses transcriptional activation by Egr2/Krox-20.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables RNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables histone deacetylase binding	IPI Inferred from Physical Interaction more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of steroid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spliceosomal snRNP assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in spliceosomal snRNP assembly	ISO Inferred from Sequence Orthology more info
involved_in spliceosomal snRNP assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Gemini of coiled bodies	IEA Inferred from Electronic Annotation more info
part_of RNA polymerase II transcription repressor complex	IDA Inferred from Direct Assay more info	PubMed
part_of SMN complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SMN complex	ISO Inferred from Sequence Orthology more info
part_of SMN complex	ISS Inferred from Sequence or Structural Similarity more info
part_of SMN-Sm protein complex	ISO Inferred from Sequence Orthology more info
part_of SMN-Sm protein complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of transcription repressor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: probable ATP-dependent RNA helicase DDX20

Names: DEAD (Asp-Glu-Ala-Asp) box polypeptide 20; DEAD box protein 20; DEAD box protein DP 103; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20; ROSF-1; component of gems 3; gemin-3; regulator of steroidogenic factor 1

NP_059093.3

EC 3.6.1.15

EC 3.6.4.13

XP_006501764.1

EC 3.6.1.15

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017397.3 → NP_059093.3 probable ATP-dependent RNA helicase DDX20

See identical proteins and their annotated locations for NP_059093.3

Status: PROVISIONAL

Source sequence(s)

BC125471

Consensus CDS

CCDS38581.1

UniProtKB/Swiss-Prot

Q059Z6, Q9JIK4, Q9JJY4

UniProtKB/TrEMBL

Q8R4Z6

Related

ENSMUSP00000088176.7, ENSMUST00000090680.11

Conserved Domains (2) summary

PRK01297
Location:18 → 413

PRK01297; ATP-dependent RNA helicase RhlB; Provisional

cd17943
Location:74 → 266

DEADc_DDX20; DEAD-box helicase domain of DEAD box protein 20

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

105585586..105595104 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006501701.4 → XP_006501764.1 probable ATP-dependent RNA helicase DDX20 isoform X1

See identical proteins and their annotated locations for XP_006501764.1

UniProtKB/Swiss-Prot

Q059Z6, Q9JIK4, Q9JJY4

UniProtKB/TrEMBL

Q8R4Z6

Conserved Domains (2) summary

PRK01297
Location:18 → 413

PRK01297; ATP-dependent RNA helicase RhlB; Provisional

cd17943
Location:74 → 266

DEADc_DDX20; DEAD-box helicase domain of DEAD box protein 20