Rab43 RAB43, member RAS oncogene family [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rab43provided by MGI
Official Full Name: RAB43, member RAS oncogene familyprovided by MGI
Primary source: MGI:MGI:1917084
See related: Ensembl:ENSMUSG00000030055 AllianceGenome:MGI:1917084
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1810048P08Rik; 2500004H21Rik
Summary: Predicted to enable GTPase activity. Acts upstream of or within cellular response to type II interferon. Located in phagocytic vesicle. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; gut; and vascular system. Orthologous to human RAB43 (RAB43, member RAS oncogene family). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Ubiquitous expression in liver adult (RPKM 39.7), spleen adult (RPKM 35.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 D1; 6 39.13 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (87765835..87789146, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (87788853..87812164, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Extracellular HMGB1 Impairs Macrophage-Mediated Efferocytosis by Suppressing the Rab43-Controlled Cell Surface Transport of CD91.
Title: Extracellular HMGB1 Impairs Macrophage-Mediated Efferocytosis by Suppressing the Rab43-Controlled Cell Surface Transport of CD91.
These results suggest that RAB43 provides a specialized activity used in cross-presentation selectively by CD8alpha(+) DCs but not other antigen-presenting cells.
Title: RAB43 facilitates cross-presentation of cell-associated antigens by CD8α+ dendritic cells.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW490415 (e-PCR)
- UniSTS:179411

NoName (e-PCR)
- UniSTS:235490

NoName (e-PCR)
- UniSTS:235491

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in Golgi organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to type II interferon	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in phagosome maturation	ISO Inferred from Sequence Orthology more info
involved_in phagosome maturation	ISS Inferred from Sequence or Structural Similarity more info
involved_in retrograde transport, plasma membrane to Golgi	ISO Inferred from Sequence Orthology more info
involved_in retrograde transport, plasma membrane to Golgi	ISS Inferred from Sequence or Structural Similarity more info
involved_in virion assembly	IEA Inferred from Electronic Annotation more info
involved_in virion assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in phagocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in phagocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in phagocytic vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ras-related protein Rab-43

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039394.1 → NP_001034483.1 ras-related protein Rab-43 isoform a

See identical proteins and their annotated locations for NP_001034483.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).

Source sequence(s)

AC158626, BY753078

Consensus CDS

CCDS20329.1

UniProtKB/Swiss-Prot

Q8CG50

UniProtKB/TrEMBL

Q0PD10

Related

ENSMUSP00000077716.5, ENSMUST00000078647.11

Conserved Domains (1) summary

cd01864
Location:14 → 178

Rab19; Rab GTPase family 19 (Rab19)
NM_133717.3 → NP_598478.1 ras-related protein Rab-43 isoform b

See identical proteins and their annotated locations for NP_598478.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate 5' terminal exon and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform b, which is shorter and has a distinct N-terminus, compared to isoform a.

Source sequence(s)

AC158626

Consensus CDS

CCDS20330.1

UniProtKB/TrEMBL

Q91Z34

Related

ENSMUSP00000032134.8, ENSMUST00000032134.9

Conserved Domains (1) summary

cl38936
Location:13 → 124

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RNA

NR_104477.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains an alternate 5' terminal exon, compared to variant 1. This variant is represented as non-coding because there is no support for the predicted protein encoded by the longest ORF.

Source sequence(s)

AC158626, AK029120, BE945886, BY151021, BY707837
NR_104478.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains an alternate 5' terminal exon, compared to variant 1. This variant is represented as non-coding because there is no support for the predicted protein encoded by the longest ORF.

Source sequence(s)

AC158626, AK029120, BE945886, BY707837, CV782943