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    Dnajc7 DnaJ heat shock protein family (Hsp40) member C7 [ Mus musculus (house mouse) ]

    Gene ID: 56354, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Dnajc7provided by MGI
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member C7provided by MGI
    Primary source
    MGI:MGI:1928373
    See related
    Ensembl:ENSMUSG00000014195 AllianceGenome:MGI:1928373
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CCRP; Ttc2; mDj11; mTpr2; 2010003F24Rik; 2010004G07Rik
    Summary
    Predicted to enable heat shock protein binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and respiratory system. Orthologous to human DNAJC7 (DnaJ heat shock protein family (Hsp40) member C7). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 43.0), CNS E14 (RPKM 34.9) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dnajc7 in Genome Data Viewer
    Location:
    11 D; 11 63.47 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100473644..100511030, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100582818..100620292, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5277 Neighboring gene outer dynein arm complex subunit 4 Neighboring gene STARR-positive B cell enhancer ABC_E8995 Neighboring gene STARR-positive B cell enhancer ABC_E7060 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:100443371-100443554 Neighboring gene 2',3'-cyclic nucleotide 3' phosphodiesterase Neighboring gene STARR-positive B cell enhancer ABC_E4000 Neighboring gene STARR-positive B cell enhancer ABC_E7061 Neighboring gene STARR-positive B cell enhancer ABC_E2369 Neighboring gene STARR-positive B cell enhancer ABC_E7062 Neighboring gene NFKB inhibitor interacting Ras-like protein 2 Neighboring gene zinc finger protein 385C Neighboring gene chromosome 11 C17orf113 homolog Neighboring gene predicted gene, 38483 Neighboring gene DExH-box helicase 58

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver. Squires EJ, et al. J Biol Chem, 2004 Nov 19. PMID 15347657
    2. DnaJC7 binds natively folded structural elements in tau to inhibit amyloid formation. Hou Z, et al. Nat Commun, 2021 Sep 9. PMID 34504072, Free PMC Article
    3. Co-Chaperone-Mediated Suppression of LPS-Induced Cardiac Toxicity Through NFκB Signaling. Ohno M, et al. Shock, 2018 Aug. PMID 30010631
    4. The roles of co-chaperone CCRP/DNAJC7 in Cyp2b10 gene activation and steatosis development in mouse livers. Ohno M, et al. PLoS One, 2014. PMID 25542016, Free PMC Article
    5. Coordinated regulation of nuclear receptor CAR by CCRP/DNAJC7, HSP70 and the ubiquitin-proteasome system. Timsit YE, et al. PLoS One, 2014. PMID 24789201, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DnaJC7 binds natively folded structural elements in tau to inhibit amyloid formation.
      Title: DnaJC7 binds natively folded structural elements in tau to inhibit amyloid formation.
    2. present study characterized a novel physiological role of CCRP in protecting cardiac functions through the inhibition of NFkappaB signaling.
      Title: Co-Chaperone-Mediated Suppression of LPS-Induced Cardiac Toxicity Through NFκB Signaling.
    3. In CCRP knockout (KO) mice CCRP regulates CAR at multiple steps in activation of the cytochrome 2b10 gene in liver: nuclear accumulation, RNA polymerase II recruitment and epigenetic modifications.
      Title: The roles of co-chaperone CCRP/DNAJC7 in Cyp2b10 gene activation and steatosis development in mouse livers.
    4. ubiquitin-proteasomal regulation of CCRP and HSP70 are important contributors to the regulation of cytoplasmic CAR levels, and hence the ability of CAR to respond to PB or PB-like inducers
      Title: Coordinated regulation of nuclear receptor CAR by CCRP/DNAJC7, HSP70 and the ubiquitin-proteasome system.
    5. cytoplasmic constitutive active/androstane receptor retention protein mediates the retention of PXR in the cytosol and modulates the activation of PXR in response to Pregnenolone Carbonitrile treatment
      Title: Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (2) 
    • Targeted (4)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone cofactor-dependent protein refolding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dnaJ homolog subfamily C member 7
    Names
    DnaJ (Hsp40) homolog, subfamily C, member 7
    TPR repeat protein 2
    cytoplasmic CAR retention protein
    tetratricopeptide repeat domain 2
    tetratricopeptide repeat protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001378962.1 → NP_001365891.1  dnaJ homolog subfamily C member 7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL591469, BX842667
      UniProtKB/TrEMBL
      A0A6I8MX00, A2A5E1
      Related
      ENSMUSP00000115438.3, ENSMUST00000146840.3
      Conserved Domains (4) summary
      PLN03088
      Location:237 → 337
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      COG0484
      Location:364 → 453
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      TIGR00990
      Location:8 → 337
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00006
      Location:241 → 268
      TPR; TPR repeat [structural motif]

    2. NM_001378963.1 → NP_001365892.1  dnaJ homolog subfamily C member 7 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL591469
      UniProtKB/TrEMBL
      A0A6I8MWW2, A0A6I8MX31
      Related
      ENSMUSP00000159367.2, ENSMUST00000154972.9
      Conserved Domains (2) summary
      TIGR00990
      Location:19 → 136
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00006
      Location:28 → 56
      TPR; TPR repeat [structural motif]

    3. NM_001403603.1 → NP_001390532.1  dnaJ homolog subfamily C member 7 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL591469, BX842667
      UniProtKB/Swiss-Prot
      Q3TKR1, Q6VVW6, Q8BPG3, Q8CIL2, Q9CT29, Q9D026, Q9QYI3
      Related
      ENSMUSP00000159311.2, ENSMUST00000239410.2

    4. NM_019795.5 → NP_062769.2  dnaJ homolog subfamily C member 7 isoform 1

      See identical proteins and their annotated locations for NP_062769.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL591469, BX842667
      Consensus CDS
      CCDS25428.1
      UniProtKB/Swiss-Prot
      Q3TKR1, Q6VVW6, Q8BPG3, Q8CIL2, Q9CT29, Q9D026, Q9QYI3
      UniProtKB/TrEMBL
      Q3UL32
      Related
      ENSMUSP00000014339.9, ENSMUST00000014339.15
      Conserved Domains (7) summary
      smart00028
      Location:28 → 61
      TPR; Tetratricopeptide repeats
      COG0484
      Location:380 → 469
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      sd00006
      Location:257 → 284
      TPR; TPR repeat [structural motif]
      pfam00226
      Location:381 → 448
      DnaJ; DnaJ domain
      pfam00515
      Location:294 → 327
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:27 → 92
      TPR_11; TPR repeat
      pfam13431
      Location:50 → 82
      TPR_17; Tetratricopeptide repeat

    RNA

    1. NR_166203.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL591469, BX842667
      Related
      ENSMUST00000239418.2

    2. NR_166204.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL591469, BX842667
      Related
      ENSMUST00000239499.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      100473644..100511030 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156865.1 → XP_036012758.1  dnaJ homolog subfamily C member 7 isoform X2

      Conserved Domains (2) summary
      TIGR00990
      Location:104 → 221
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00006
      Location:113 → 141
      TPR; TPR repeat [structural motif]

    RNA

    1. XR_001780034.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QYI3.2 GenPept UniProtKB/Swiss-Prot:Q9QYI3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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