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    Ggt7 gamma-glutamyltransferase 7 [ Mus musculus (house mouse) ]

    Gene ID: 207182, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Ggt7provided by MGI
    Official Full Name
    gamma-glutamyltransferase 7provided by MGI
    Primary source
    MGI:MGI:1913385
    See related
    Ensembl:ENSMUSG00000027603 AllianceGenome:MGI:1913385
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ggtl3; 1110017C11Rik; 6330563L03Rik
    Summary
    Predicted to enable glutathione hydrolase activity and peptidyltransferase activity. Predicted to be involved in several processes, including glutathione catabolic process; response to estradiol; and response to tumor necrosis factor. Predicted to act upstream of or within glutathione biosynthetic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including glans of male genital tubercle; nervous system; and sensory organ. Orthologous to human GGT7 (gamma-glutamyltransferase 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cerebellum adult (RPKM 36.7), cortex adult (RPKM 34.9) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ggt7 in Genome Data Viewer
    Location:
    2 H1; 2 77.26 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (155332299..155356921, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (155490379..155514891, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene nuclear receptor coactivator 6 Neighboring gene carnitine deficiency-associated gene expressed in ventricle 3 pseudogene Neighboring gene cytochrome c, somatic pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1258 Neighboring gene acyl-CoA synthetase short-chain family member 2 Neighboring gene STARR-positive B cell enhancer ABC_E7875 Neighboring gene acyl-CoA synthetase short-chain family member 2, opposite strand Neighboring gene glutathione synthase, opposite strand 2 Neighboring gene glutathione synthetase Neighboring gene STARR-seq mESC enhancer starr_06145 Neighboring gene STARR-positive B cell enhancer ABC_E6005

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Control of liver cell fate decision by a gradient of TGF beta signaling modulated by Onecut transcription factors. Clotman F, et al. Genes Dev, 2005 Aug 15. PMID 16103213, Free PMC Article
    2. High-throughput sequence identification of gene coding variants within alcohol-related QTLs. Ehringer MA, et al. Mamm Genome, 2001 Aug. PMID 11471062
    3. Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Apr 30. PMID 15449545
    4. Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells. Zhang M, et al. Mol Cell Proteomics, 2014 Nov. PMID 25044020, Free PMC Article
    5. Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub. Forrest MP, et al. Nat Commun, 2023 Feb 17. PMID 36808153, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC12004

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glutathione hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables leukotriene C4 gamma-glutamyl transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutathione catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glutathione hydrolase 7
    Names
    GGT 7
    gamma-glutamyltransferase-like 3
    gamma-glutamyltranspeptidase 7
    mFLJ00311 protein
    NP_001349827.1
    NP_001349829.1
    NP_659035.2
    XP_006499123.1
    XP_030104806.1
    XP_030104809.1
    XP_030104811.1
    XP_030104813.1
    XP_030104814.1
    XP_030104815.1
    XP_036015867.1
    XP_036015873.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362898.1 → NP_001349827.1  glutathione hydrolase 7 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL844852
      Conserved Domains (1) summary
      pfam01019
      Location:155 → 658
      G_glu_transpept; Gamma-glutamyltranspeptidase

    2. NM_001362900.1 → NP_001349829.1  glutathione hydrolase 7 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses two alternate splice junctions compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL844852
      Conserved Domains (1) summary
      cl19223
      Location:1 → 421
      G_glu_transpept; Gamma-glutamyltranspeptidase

    3. NM_144786.2 → NP_659035.2  glutathione hydrolase 7 isoform 2

      See identical proteins and their annotated locations for NP_659035.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK032051, AK177521, BY127251
      Consensus CDS
      CCDS16949.1
      UniProtKB/Swiss-Prot
      A2AQN1, Q91V91, Q99JP7
      Related
      ENSMUSP00000029131.5, ENSMUST00000029131.11
      Conserved Domains (1) summary
      pfam01019
      Location:155 → 654
      G_glu_transpept; Gamma-glutamyltranspeptidase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      155332299..155356921 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248955.2 → XP_030104815.1  glutathione hydrolase 7 isoform X6

      Conserved Domains (1) summary
      cl19223
      Location:155 → 607
      G_glu_transpept; Gamma-glutamyltranspeptidase

    2. XM_006499060.3 → XP_006499123.1  glutathione hydrolase 7 isoform X1

      Conserved Domains (1) summary
      cl19223
      Location:155 → 642
      G_glu_transpept; Gamma-glutamyltranspeptidase

    3. XM_030248949.2 → XP_030104809.1  glutathione hydrolase 7 isoform X4

      Conserved Domains (1) summary
      cl19223
      Location:38 → 443
      G_glu_transpept; Gamma-glutamyltranspeptidase

    4. XM_030248951.2 → XP_030104811.1  glutathione hydrolase 7 isoform X4

      Conserved Domains (1) summary
      cl19223
      Location:38 → 443
      G_glu_transpept; Gamma-glutamyltranspeptidase

    5. XM_030248953.2 → XP_030104813.1  glutathione hydrolase 7 isoform X4

      Conserved Domains (1) summary
      cl19223
      Location:38 → 443
      G_glu_transpept; Gamma-glutamyltranspeptidase

    6. XM_030248946.1 → XP_030104806.1  glutathione hydrolase 7 isoform X3

      Conserved Domains (1) summary
      pfam01019
      Location:1 → 464
      G_glu_transpept; Gamma-glutamyltranspeptidase

    7. XM_036159974.1 → XP_036015867.1  glutathione hydrolase 7 isoform X2

      Conserved Domains (1) summary
      pfam01019
      Location:1 → 470
      G_glu_transpept; Gamma-glutamyltranspeptidase

    8. XM_030248954.2 → XP_030104814.1  glutathione hydrolase 7 isoform X4

      Conserved Domains (1) summary
      cl19223
      Location:38 → 443
      G_glu_transpept; Gamma-glutamyltranspeptidase

    9. XM_036159980.1 → XP_036015873.1  glutathione hydrolase 7 isoform X5

      Conserved Domains (1) summary
      cl19223
      Location:1 → 421
      G_glu_transpept; Gamma-glutamyltranspeptidase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99JP7.2 GenPept UniProtKB/Swiss-Prot:Q99JP7

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