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    SLC30A1 solute carrier family 30 member 1 [ Homo sapiens (human) ]

    Gene ID: 7779, updated on 9-Dec-2024

    Summary

    Official Symbol
    SLC30A1provided by HGNC
    Official Full Name
    solute carrier family 30 member 1provided by HGNC
    Primary source
    HGNC:HGNC:11012
    See related
    Ensembl:ENSG00000170385 MIM:609521; AllianceGenome:HGNC:11012
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNT1; ZRC1
    Summary
    Predicted to enable calcium channel inhibitor activity and zinc:proton antiporter activity. Involved in defense response to bacterium; intracellular zinc ion homeostasis; and zinc ion import into organelle. Located in several cellular components, including Golgi apparatus; basolateral plasma membrane; and nuclear membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver (RPKM 22.8), duodenum (RPKM 15.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SLC30A1 in Genome Data Viewer
    Location:
    1q32.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (211571568..211579161, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (210817650..210825243, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (211744910..211752503, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RD3 regulator of GUCY2D Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1786 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1787 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2487 Neighboring gene uncharacterized LOC107985261 Neighboring gene uncharacterized LOC107985260 Neighboring gene MPRA-validated peak683 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:211711705-211712205 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:211721978-211722385 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1788 Neighboring gene H3K27ac hESC enhancers GRCh37_chr1:211751675-211752176 and GRCh37_chr1:211752177-211752676 Neighboring gene uncharacterized LOC105372903 Neighboring gene Sharpr-MPRA regulatory region 10274 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:211794336-211794836 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:211805695-211806270 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:211815933-211816768 Neighboring gene Sharpr-MPRA regulatory region 10021 Neighboring gene non-coding transcript regulating alternative splicing

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium channel inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium channel inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables zinc ion transmembrane transporter activity TAS
    Traceable Author Statement
    more info
     
    enables zinc:proton antiporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in cadmium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in calcium ion import IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response to bacterium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in detoxification of cadmium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in detoxification of zinc ion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular calcium ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intracellular zinc ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular zinc ion homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in intracellular zinc ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of calcium ion import ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of neurotransmitter secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of zinc ion transmembrane import ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of dendritic spine morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of postsynaptic density protein 95 clustering IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in zinc export across plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in zinc ion import into organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in zinc ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in zinc ion transmembrane transport TAS
    Traceable Author Statement
    more info
     
    involved_in zinc ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Schaffer collateral - CA1 synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in T-tubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in glutamatergic postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in postsynaptic density membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in postsynaptic density, intracellular component IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    proton-coupled zinc antiporter SLC30A1
    Names
    solute carrier family 30 (zinc transporter), member 1
    zinc resistance conferring homolog
    zinc transporter 1
    znT-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021194.3NP_067017.2  proton-coupled zinc antiporter SLC30A1

      See identical proteins and their annotated locations for NP_067017.2

      Status: VALIDATED

      Source sequence(s)
      AA853540, AC105275, AI467909, AI621266, AW183618, BE744293, BF057194, CB990012, CF529684
      Consensus CDS
      CCDS1499.1
      UniProtKB/Swiss-Prot
      Q0VAK9, Q9BZF6, Q9Y6M5
      Related
      ENSP00000355968.4, ENST00000367001.5
      Conserved Domains (1) summary
      COG1230
      Location:6423
      CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      211571568..211579161 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      210817650..210825243 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)