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    FBXL21P F-box and leucine rich repeat protein 21, pseudogene [ Homo sapiens (human) ]

    Gene ID: 26223, updated on 2-Nov-2024

    Summary

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    Official Symbol
    FBXL21Pprovided by HGNC
    Official Full Name
    F-box and leucine rich repeat protein 21, pseudogeneprovided by HGNC
    Primary source
    HGNC:HGNC:13600
    See related
    MIM:609087; AllianceGenome:HGNC:13600
    Gene type
    pseudo
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FBL3B; Fbl21; FBXL21; FBXL3B; FBXL3P
    Summary
    This locus represents a transcribed pseudogene that is related to genes encoding members of the F-box family of proteins. [provided by RefSeq, Nov 2017]
    Annotation information
    Annotation category: suggests misassembly
    Expression
    Biased expression in prostate (RPKM 1.0), adrenal (RPKM 0.7) and 8 other tissues See more
    Orthologs
    all
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    Genomic context

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    See FBXL21P in Genome Data Viewer
    Location:
    5q31.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (135930297..135941996)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (136452800..136464501)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (135265986..135277685)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 48 Neighboring gene uncharacterized LOC107986453 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:135169317-135169818 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:135213247-135213748 Neighboring gene uncharacterized LOC124901074 Neighboring gene interleukin 9 Neighboring gene Sharpr-MPRA regulatory region 2274 Neighboring gene NANOG hESC enhancer GRCh37_chr5:135310975-135311476 Neighboring gene leukocyte cell derived chemotaxin 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:135337055-135337556 Neighboring gene uncharacterized LOC105379189

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. FBXL21 association with schizophrenia in Irish family and case-control samples. Chen X, et al. Am J Med Genet B Neuropsychiatr Genet, 2008 Oct 5. PMID 18404645, Free PMC Article
    2. The circadian E3 ligase FBXL21 regulates myoblast differentiation and sarcomere architecture via MYOZ1 ubiquitination and NFAT signaling. Lim JY, et al. PLoS Genet, 2022 Dec. PMID 36574402, Free PMC Article
    3. Ubiquitination of inositol-requiring enzyme 1 (IRE1) by the E3 ligase CHIP mediates the IRE1/TRAF2/JNK pathway. Zhu X, et al. J Biol Chem, 2014 Oct 31. PMID 25225294, Free PMC Article
    4. The GSK-3β-FBXL21 Axis Contributes to Circadian TCAP Degradation and Skeletal Muscle Function. Wirianto M, et al. Cell Rep, 2020 Sep 15. PMID 32937135, Free PMC Article
    5. Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex. Yumimoto K, et al. J Biol Chem, 2013 Nov 8. PMID 24085301, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Using both family and case-control samples, consistent associations in and around FBXL21 gene suggested that FBXL21 may be associated with schizophrenia in the Irish samples.
      Title: FBXL21 association with schizophrenia in Irish family and case-control samples.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: New genetic associations detected in a host response study to hepatitis B vaccine.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Other Names

    • F-box and leucine-rich repeat protein 21
    • F-box and leucine-rich repeat protein 3 pseudogene
    • F-box and leucine-rich repeat protein 3B
    • F-box protein Fbl3b
    • F-box/LRR-repeat protein 21
    • F-box/LRR-repeat protein 3B

    Clone Names

    • MGC120237

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in entrainment of circadian clock by photoperiod IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in entrainment of circadian clock by photoperiod ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in rhythmic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SCF ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of ubiquitin ligase complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_152420.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC002428

    2. NR_152421.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC002428

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      135930297..135941996
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      136452800..136464501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_012159.4: Suppressed sequence

      Description
      NM_012159.4: This RefSeq was removed because it is now thought that this gene is a pseudogene.

    2. NR_132347.1: Suppressed sequence

      Description
      NR_132347.1: This RefSeq was removed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UKT6.1 GenPept UniProtKB/Swiss-Prot:Q9UKT6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials