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    P2RY4 pyrimidinergic receptor P2Y4 [ Homo sapiens (human) ]

    Gene ID: 5030, updated on 10-Dec-2024

    Summary

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    Official Symbol
    P2RY4provided by HGNC
    Official Full Name
    pyrimidinergic receptor P2Y4provided by HGNC
    Primary source
    HGNC:HGNC:8542
    See related
    Ensembl:ENSG00000186912 MIM:300038; AllianceGenome:HGNC:8542
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NRU; P2P; UNR; P2Y4
    Summary
    The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to uridine nucleotides, partially responsive to ATP, and not responsive to ADP. [provided by RefSeq, Jul 2008]
    Orthologs
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    Genomic context

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    See P2RY4 in Genome Data Viewer
    Location:
    Xq13.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (70258166..70260204, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (68691490..68693528, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (69478016..69480054, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene acyl-CoA wax alcohol acyltransferase 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:69473037-69474236 Neighboring gene RNA, 5S ribosomal pseudogene 507 Neighboring gene Sharpr-MPRA regulatory region 5483 Neighboring gene arrestin 3 Neighboring gene RAB41, member RAS oncogene family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning, expression, and chromosomal localization of the human uridine nucleotide receptor gene. Nguyen T, et al. J Biol Chem, 1995 Dec 29. PMID 8537335
    2. Cloning and functional expression of a human uridine nucleotide receptor. Communi D, et al. J Biol Chem, 1995 Dec 29. PMID 8537336
    3. Molecular cloning and characterization of a novel orphan receptor (P2P) expressed in human pancreas that shows high structural homology to the P2U purinoceptor. Stam NJ, et al. FEBS Lett, 1996 Apr 22. PMID 8617367
    4. Nucleotides induce chemotaxis and actin polymerization in immature but not mature human dendritic cells via activation of pertussis toxin-sensitive P2y receptors. Idzko M, et al. Blood, 2002 Aug 1. PMID 12130504
    5. The metabotropic P2Y4 receptor participates in the commitment to differentiation and cell death of human neuroblastoma SH-SY5Y cells. Cavaliere F, et al. Neurobiol Dis, 2005 Feb. PMID 15649700

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. reflected in the immunoblotting data P2RY4 receptors were detected at higher levels of expression in patient with cortical dysplasia with intractable epilepsy.
      Title: Expression of astrocyte-related receptors in cortical dysplasia with intractable epilepsy.
    2. P2Y4 receptors are expressed in intracellular vesicles and sarcolemma of skeletal muscle fibers.
      Title: Purinergic receptors expressed in human skeletal muscle fibres.
    3. show that P2 receptors and protein kinases are also involved in regulating injury-induced expression and the release of TSP-1 in injured astrocytes
      Title: Trauma-induced expression of astrocytic thrombospondin-1 is regulated by P2 receptors coupled to protein kinase cascades.
    4. Nucleotide P2Y4 receptor binding is arrested in post-Golgi trafficking by type I transmembrane proteins p23 and p24A.
      Title: Proteinase-activated receptors, nucleotide P2Y receptors, and μ-opioid receptor-1B are under the control of the type I transmembrane proteins p23 and p24A in post-Golgi trafficking.
    5. Taken together, our data indicate that the high expression and activation of the P2Y4 receptor participates in the neuronal differentiation and commitment to death of SH-SY5Y cells.
      Title: The metabotropic P2Y4 receptor participates in the commitment to differentiation and cell death of human neuroblastoma SH-SY5Y cells.
    6. Activation of the human P2Y(4) receptor expressed in 1321N1 cells by UTP did not elicit this protective effect, although both receptors were coupled to phospholipase C.
      Title: Tumor necrosis factor alpha-induced apoptosis in astrocytes is prevented by the activation of P2Y6, but not P2Y4 nucleotide receptors.
    7. expression profile in human peripheral tissues and brain regions using PCR
      Title: Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study.
    8. second extracellular loop and the NH(2) terminus form a functional motif that plays a key role in determining whether ATP functions as an agonist or antagonist at mammalian P2Y(4) receptors
      Title: Agonist versus antagonist action of ATP at the P2Y4 receptor is determined by the second extracellular loop.
    9. Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors.
      Title: Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled UTP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled UTP receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables G protein-coupled purinergic nucleotide receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled purinergic nucleotide receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to ATP TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cellular response to prostaglandin E stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of presynaptic cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of synaptic vesicle exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transepithelial chloride transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in presynaptic active zone membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    P2Y purinoceptor 4
    Names
    pyrimidinergic receptor P2Y, G-protein coupled, 4
    uridine nucleotide receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013250.1 RefSeqGene

      Range
      4601..6639
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002565.4 → NP_002556.1  P2Y purinoceptor 4

      See identical proteins and their annotated locations for NP_002556.1

      Status: REVIEWED

      Source sequence(s)
      AL357752
      Consensus CDS
      CCDS14398.1
      UniProtKB/Swiss-Prot
      P51582, Q4VBB7, Q4VBB8, Q502W2, Q5JT22
      Related
      ENSP00000363643.2, ENST00000374519.4
      Conserved Domains (1) summary
      cd15374
      Location:36 → 317
      7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      70258166..70260204 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      68691490..68693528 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51582.1 GenPept UniProtKB/Swiss-Prot:P51582

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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