U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    FJX1 four-jointed box kinase 1 [ Homo sapiens (human) ]

    Gene ID: 24147, updated on 26-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    FJX1provided by HGNC
    Official Full Name
    four-jointed box kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:17166
    See related
    Ensembl:ENSG00000179431 MIM:612206; AllianceGenome:HGNC:17166
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is the human ortholog of mouse and Drosophila four-jointed gene product. The Drosophila protein is important for growth and differentiation of legs and wings, and for proper development of the eyes. The exact function of this gene in humans is not known. [provided by RefSeq, Jul 2008]
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See FJX1 in Genome Data Viewer
    Location:
    11p13
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (35618460..35620865)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (35757225..35759630)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (35640008..35642413)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 1 member 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:35440751-35441251 Neighboring gene SLC1A2 antisense RNA 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3258 Neighboring gene peptidase domain containing associated with muscle regeneration 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4624 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3259 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:35639867-35640028 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3261 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:35640328-35640962 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:35640963-35641597 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:35650952-35652151 Neighboring gene NANOG hESC enhancer GRCh37_chr11:35676186-35676747 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4625 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:35684511-35685011 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_21277 Neighboring gene tripartite motif containing 44 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4626 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4627 Neighboring gene OCT4 hESC enhancer GRCh37_chr11:35774016-35774517 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_21295 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:35793100-35793607 Neighboring gene keratin 18 pseudogene 14

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. An Oncogenic Role for Four-Jointed Box 1 (FJX1) in Nasopharyngeal Carcinoma. Chai SJ, et al. Dis Markers, 2019. PMID 31236144, Free PMC Article
    2. Overexpression of Four Joint Box-1 Protein (FJX1) in Eutopic Endometrium From Women With Endometriosis. Chang HJ, et al. Reprod Sci, 2018 Feb. PMID 28673206, Free PMC Article
    3. [FJX1 overexpression is associated with poor prognosis and promotes gastric cancer proliferation via the PI3K/AKT signaling pathway]. Zhang H, et al. Nan Fang Yi Ke Da Xue Xue Bao, 2023 Jun 20. PMID 37439170, Free PMC Article
    4. MiR-532-3p suppresses cell proliferation, migration and invasion of colon adenocarcinoma via targeting FJX1. Cheng T, et al. Pathol Res Pract, 2022 Apr. PMID 35278814
    5. MicroRNA-1249 targets four-jointed box kinase 1 and reduces cell proliferation, migration and invasion of colon adenocarcinoma. Dang W, et al. J Gene Med, 2020 Jul. PMID 32159255

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. [FJX1 overexpression is associated with poor prognosis and promotes gastric cancer proliferation via the PI3K/AKT signaling pathway].
      Title: [FJX1 overexpression is associated with poor prognosis and promotes gastric cancer proliferation via the PI3K/AKT signaling pathway].
    2. MiR-532-3p suppresses cell proliferation, migration and invasion of colon adenocarcinoma via targeting FJX1.
      Title: MiR-532-3p suppresses cell proliferation, migration and invasion of colon adenocarcinoma via targeting FJX1.
    3. MicroRNA-1249 targets four-jointed box kinase 1 and reduces cell proliferation, migration and invasion of colon adenocarcinoma.
      Title: MicroRNA-1249 targets four-jointed box kinase 1 and reduces cell proliferation, migration and invasion of colon adenocarcinoma.
    4. FOXD3-AS1 Contributes to the Progression of Melanoma Via miR-127-3p/FJX1 Axis.
      Title: FOXD3-AS1 Contributes to the Progression of Melanoma Via miR-127-3p/FJX1 Axis.
    5. FJX1 transcript and protein level is upregulated in nasopharyngeal carcinoma tissue samples. FJX1 promotes cell proliferation, anchorage-dependent growth, and cellular invasion in vitro.
      Title: An Oncogenic Role for Four-Jointed Box 1 (FJX1) in Nasopharyngeal Carcinoma.
    6. The results of our Western blot analysis reveal a significant positive correlation between FJX1 and HIF1alpha proteins in endometrium of women with and without endometriosis.
      Title: Overexpression of Four Joint Box-1 Protein (FJX1) in Eutopic Endometrium From Women With Endometriosis.
    7. FJX1 does not influence the levels of FAT1 ectodomain phosphorylation.
      Title: FAT1 cadherin is multiply phosphorylated on its ectodomain but phosphorylation is not catalysed by the four-jointed homologue.
    Submit: New GeneRIF Correction

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in cell-cell signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retina layer formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    four-jointed box protein 1
    Names
    four jointed box 1
    four-jointed protein homolog
    putative secreted ligand homologous to fjx1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014344.4 → NP_055159.2  four-jointed box protein 1

      See identical proteins and their annotated locations for NP_055159.2

      Status: REVIEWED

      Source sequence(s)
      AK026069, BC049171
      Consensus CDS
      CCDS44570.1
      UniProtKB/Swiss-Prot
      B2RCA9, Q86VR8, Q9UGK6
      Related
      ENSP00000400223.1, ENST00000317811.6
      Conserved Domains (1) summary
      cd10468
      Location:149 → 430
      Four-jointed-like_C; C-terminal kinase domain of Drosophila Four-jointed (Fj), mouse Fjx1, and related proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      35618460..35620865
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      35757225..35759630
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86VR8.1 GenPept UniProtKB/Swiss-Prot:Q86VR8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools