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    DZIP3 DAZ interacting zinc finger protein 3 [ Homo sapiens (human) ]

    Gene ID: 9666, updated on 10-Dec-2024

    Summary

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    Official Symbol
    DZIP3provided by HGNC
    Official Full Name
    DAZ interacting zinc finger protein 3provided by HGNC
    Primary source
    HGNC:HGNC:30938
    See related
    Ensembl:ENSG00000198919 MIM:608672; AllianceGenome:HGNC:30938
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UURF2; PPP1R66; hRUL138
    Summary
    Enables several functions, including phosphatase binding activity; polyubiquitin modification-dependent protein binding activity; and ubiquitin-protein transferase activity. Involved in protein polyubiquitination. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 21.6), brain (RPKM 12.1) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DZIP3 in Genome Data Viewer
    Location:
    3q13.13
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (108589510..108694840)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (111309763..111415213)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (108308569..108413687)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene myosin heavy chain 15 Neighboring gene ribosomal protein L13 pseudogene 8 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene cellular inhibitor of PP2A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20222 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:108396720-108396891 Neighboring gene uncharacterized LOC105374033 Neighboring gene uncharacterized LOC105374034 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:108462949-108464148

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. DZIP3 is a key factor to stratify IDH1 wild-type lower-grade gliomas. Liang T, et al. Aging (Albany NY), 2020 Nov 21. PMID 33229627, Free PMC Article
    2. RNA-Binding RING E3-Ligase DZIP3/hRUL138 Stabilizes Cyclin D1 to Drive Cell-Cycle and Cancer Progression. Kolapalli SP, et al. Cancer Res, 2021 Jan 15. PMID 33067265, Free PMC Article
    3. hRUL138, a novel human RNA-binding RING-H2 ubiquitin-protein ligase. Kreft SG, et al. J Cell Sci, 2003 Feb 15. PMID 12538761
    4. Novel CARM1-Interacting Protein, DZIP3, Is a Transcriptional Coactivator of Estrogen Receptor-α. Purcell DJ, et al. Mol Endocrinol, 2015 Dec. PMID 26505218, Free PMC Article
    5. Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination. Yoon JH, et al. Nat Commun, 2013. PMID 24326307, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Proteomic analysis of DZIP3 interactome and its role in proliferation and metastasis in gastric cancer cells.
      Title: Proteomic analysis of DZIP3 interactome and its role in proliferation and metastasis in gastric cancer cells.
    2. DZIP3 is a key factor to stratify IDH1 wild-type lower-grade gliomas.
      Title: DZIP3 is a key factor to stratify IDH1 wild-type lower-grade gliomas.
    3. RNA-Binding RING E3-Ligase DZIP3/hRUL138 Stabilizes Cyclin D1 to Drive Cell-Cycle and Cancer Progression.
      Title: RNA-Binding RING E3-Ligase DZIP3/hRUL138 Stabilizes Cyclin D1 to Drive Cell-Cycle and Cancer Progression.
    4. By monoubiquitination of H2A at lysine 119, 2A-HUB mediates a selective repression of a specific set of chemokine genes in macrophages, critically modulating migratory responses to TLR activation.
      Title: Histone H2A monoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ13327, FLJ57977, FLJ58022, FLJ58223, KIAA0675

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polyubiquitin modification-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase DZIP3
    Names
    DAZ interacting protein 3, zinc finger
    DAZ-interacting protein 3
    RING-type E3 ubiquitin transferase DZIP3
    RNA-binding RING-H2 protein-ubiquitin ligase
    RNA-binding ubiquitin ligase of 138 kDa
    UURF2 ubiquitin ligase
    human RNA-binding ubiquitin ligase of 138 kDa
    protein phosphatase 1, regulatory subunit 66
    zinc finger DAZ interacting protein 3
    NP_055463.1
    XP_005247971.1
    XP_005247972.1
    XP_005247973.1
    XP_005247974.1
    XP_005247975.1
    XP_005247976.1
    XP_016863029.1
    XP_047305210.1
    XP_047305211.1
    XP_047305212.1
    XP_047305213.1
    XP_047305214.1
    XP_054204461.1
    XP_054204462.1
    XP_054204463.1
    XP_054204464.1
    XP_054204465.1
    XP_054204466.1
    XP_054204467.1
    XP_054204468.1
    XP_054204469.1
    XP_054204470.1
    XP_054204471.1
    XP_054204472.1
    XP_054204473.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014648.4 → NP_055463.1  E3 ubiquitin-protein ligase DZIP3

      See identical proteins and their annotated locations for NP_055463.1

      Status: VALIDATED

      Source sequence(s)
      AC092185, AC092693
      Consensus CDS
      CCDS2952.1
      UniProtKB/Swiss-Prot
      B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9
      Related
      ENSP00000355028.3, ENST00000361582.8
      Conserved Domains (2) summary
      cd16460
      Location:1147 → 1188
      RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
      cl25732
      Location:675 → 856
      SMC_N; RecF/RecN/SMC N terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      108589510..108694840
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005247917.4 → XP_005247974.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

      See identical proteins and their annotated locations for XP_005247974.1

      UniProtKB/Swiss-Prot
      B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9
      Conserved Domains (2) summary
      cd16460
      Location:1147 → 1188
      RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
      cl25732
      Location:675 → 856
      SMC_N; RecF/RecN/SMC N terminal domain

    2. XM_005247914.5 → XP_005247971.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

      See identical proteins and their annotated locations for XP_005247971.1

      UniProtKB/Swiss-Prot
      B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9
      Conserved Domains (2) summary
      cd16460
      Location:1147 → 1188
      RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
      cl25732
      Location:675 → 856
      SMC_N; RecF/RecN/SMC N terminal domain

    3. XM_047449256.1 → XP_047305212.1  E3 ubiquitin-protein ligase DZIP3 isoform X4

    4. XM_005247918.4 → XP_005247975.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

      See identical proteins and their annotated locations for XP_005247975.1

      UniProtKB/Swiss-Prot
      B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9
      Conserved Domains (2) summary
      cd16460
      Location:1147 → 1188
      RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
      cl25732
      Location:675 → 856
      SMC_N; RecF/RecN/SMC N terminal domain

    5. XM_005247919.5 → XP_005247976.1  E3 ubiquitin-protein ligase DZIP3 isoform X4

      Conserved Domains (2) summary
      pfam12678
      Location:941 → 982
      zf-rbx1; RING-H2 zinc finger
      pfam13639
      Location:942 → 982
      zf-RING_2; Ring finger domain

    6. XM_047449254.1 → XP_047305210.1  E3 ubiquitin-protein ligase DZIP3 isoform X2

    7. XM_047449255.1 → XP_047305211.1  E3 ubiquitin-protein ligase DZIP3 isoform X3

    8. XM_047449257.1 → XP_047305213.1  E3 ubiquitin-protein ligase DZIP3 isoform X5

    9. XM_047449258.1 → XP_047305214.1  E3 ubiquitin-protein ligase DZIP3 isoform X6

      UniProtKB/TrEMBL
      C9J9M8
      Related
      ENSP00000418115.1, ENST00000479138.5

    10. XM_017007540.2 → XP_016863029.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

      UniProtKB/Swiss-Prot
      B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9
      Conserved Domains (2) summary
      cd16460
      Location:1147 → 1188
      RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
      cl25732
      Location:675 → 856
      SMC_N; RecF/RecN/SMC N terminal domain

    11. XM_005247916.4 → XP_005247973.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

      See identical proteins and their annotated locations for XP_005247973.1

      UniProtKB/Swiss-Prot
      B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9
      Conserved Domains (2) summary
      cd16460
      Location:1147 → 1188
      RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
      cl25732
      Location:675 → 856
      SMC_N; RecF/RecN/SMC N terminal domain

    12. XM_005247915.4 → XP_005247972.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

      See identical proteins and their annotated locations for XP_005247972.1

      UniProtKB/Swiss-Prot
      B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9
      Related
      ENSP00000419981.1, ENST00000463306.1
      Conserved Domains (2) summary
      cd16460
      Location:1147 → 1188
      RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
      cl25732
      Location:675 → 856
      SMC_N; RecF/RecN/SMC N terminal domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      111309763..111415213
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348490.1 → XP_054204465.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

      UniProtKB/Swiss-Prot
      B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9

    2. XM_054348492.1 → XP_054204467.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

      UniProtKB/Swiss-Prot
      B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9

    3. XM_054348488.1 → XP_054204463.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

      UniProtKB/Swiss-Prot
      B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9

    4. XM_054348496.1 → XP_054204471.1  E3 ubiquitin-protein ligase DZIP3 isoform X4

    5. XM_054348495.1 → XP_054204470.1  E3 ubiquitin-protein ligase DZIP3 isoform X4

    6. XM_054348493.1 → XP_054204468.1  E3 ubiquitin-protein ligase DZIP3 isoform X2

    7. XM_054348494.1 → XP_054204469.1  E3 ubiquitin-protein ligase DZIP3 isoform X3

    8. XM_054348497.1 → XP_054204472.1  E3 ubiquitin-protein ligase DZIP3 isoform X5

    9. XM_054348498.1 → XP_054204473.1  E3 ubiquitin-protein ligase DZIP3 isoform X6

      UniProtKB/TrEMBL
      C9J9M8

    10. XM_054348489.1 → XP_054204464.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

      UniProtKB/Swiss-Prot
      B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9

    11. XM_054348486.1 → XP_054204461.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

      UniProtKB/Swiss-Prot
      B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9

    12. XM_054348487.1 → XP_054204462.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

      UniProtKB/Swiss-Prot
      B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9

    13. XM_054348491.1 → XP_054204466.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

      UniProtKB/Swiss-Prot
      B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86Y13.2 GenPept UniProtKB/Swiss-Prot:Q86Y13

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