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    SGPL1 sphingosine-1-phosphate lyase 1 [ Homo sapiens (human) ]

    Gene ID: 8879, updated on 9-Dec-2024

    Summary

    Official Symbol
    SGPL1provided by HGNC
    Official Full Name
    sphingosine-1-phosphate lyase 1provided by HGNC
    Primary source
    HGNC:HGNC:10817
    See related
    Ensembl:ENSG00000166224 MIM:603729; AllianceGenome:HGNC:10817
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SPL; RENI; S1PL; NPHS14
    Summary
    Enables sphinganine-1-phosphate aldolase activity. Involved in apoptotic signaling pathway; fatty acid metabolic process; and sphingolipid metabolic process. Located in endoplasmic reticulum. Implicated in nephrotic syndrome type 14. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in urinary bladder (RPKM 14.9), skin (RPKM 13.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SGPL1 in Genome Data Viewer
    Location:
    10q22.1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (70815948..70881184)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (71685701..71750988)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (72575704..72640941)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72536007-72536834 Neighboring gene thymus, brain and testes associated Neighboring gene ribosomal protein S26 pseudogene 40 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2451 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2452 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2453 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2454 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2455 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2456 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2457 Neighboring gene pterin-4 alpha-carbinolamine dehydratase 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72663371-72663919 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:72677493-72677667 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:72678259-72678439 Neighboring gene long intergenic non-protein coding RNA 2622

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpu vpu HIV-1 Vpu is identified to have a physical interaction with sphingosine-1-phosphate lyase 1 (SGPL1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ13811, KIAA1252

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables sphinganine-1-phosphate aldolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sphinganine-1-phosphate aldolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sphinganine-1-phosphate aldolase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables sphinganine-1-phosphate aldolase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables sphinganine-1-phosphate aldolase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    involved_in Leydig cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in androgen metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ceramide metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in estrogen metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in face morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in fibroblast migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hemopoiesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in kidney development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in luteinization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in platelet-derived growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in post-embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in roof of mouth development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in skeletal system morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sphingolipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sphingolipid catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in sphingolipid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sphingolipid catabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in sphingolipid catabolic process TAS
    Traceable Author Statement
    more info
     
    involved_in vasculogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    sphingosine-1-phosphate lyase 1
    Names
    SP-lyase 1
    SPL 1
    hSPL
    sphingosine-1-phosphate aldolase
    NP_003892.2
    XP_005270320.1
    XP_011538618.1
    XP_011538619.1
    XP_011538620.1
    XP_047281937.1
    XP_047281938.1
    XP_054223076.1
    XP_054223077.1
    XP_054223078.1
    XP_054223079.1
    XP_054223080.1
    XP_054223081.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003901.4NP_003892.2  sphingosine-1-phosphate lyase 1

      See identical proteins and their annotated locations for NP_003892.2

      Status: VALIDATED

      Source sequence(s)
      AC073176, BC052991, BP314104
      Consensus CDS
      CCDS31216.1
      UniProtKB/Swiss-Prot
      B2RBD4, O95470, Q7Z732, Q9ULG8, Q9UN89
      Related
      ENSP00000362298.3, ENST00000373202.8
      Conserved Domains (1) summary
      cd06450
      Location:144507
      DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      70815948..70881184
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047425981.1XP_047281937.1  sphingosine-1-phosphate lyase 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBD4, O95470, Q7Z732, Q9ULG8, Q9UN89
    2. XM_011540316.3XP_011538618.1  sphingosine-1-phosphate lyase 1 isoform X1

      See identical proteins and their annotated locations for XP_011538618.1

      UniProtKB/Swiss-Prot
      B2RBD4, O95470, Q7Z732, Q9ULG8, Q9UN89
      Conserved Domains (1) summary
      cd06450
      Location:144507
      DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
    3. XM_011540318.2XP_011538620.1  sphingosine-1-phosphate lyase 1 isoform X2

      See identical proteins and their annotated locations for XP_011538620.1

      UniProtKB/TrEMBL
      A0A8V8TN35
      Related
      ENSP00000513481.1, ENST00000697927.1
      Conserved Domains (1) summary
      cd06450
      Location:64427
      DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
    4. XM_047425982.1XP_047281938.1  sphingosine-1-phosphate lyase 1 isoform X3

    5. XM_005270263.2XP_005270320.1  sphingosine-1-phosphate lyase 1 isoform X1

      See identical proteins and their annotated locations for XP_005270320.1

      UniProtKB/Swiss-Prot
      B2RBD4, O95470, Q7Z732, Q9ULG8, Q9UN89
      Related
      ENSP00000513485.1, ENST00000697931.1
      Conserved Domains (1) summary
      cd06450
      Location:144507
      DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
    6. XM_011540317.2XP_011538619.1  sphingosine-1-phosphate lyase 1 isoform X1

      See identical proteins and their annotated locations for XP_011538619.1

      UniProtKB/Swiss-Prot
      B2RBD4, O95470, Q7Z732, Q9ULG8, Q9UN89
      Related
      ENSP00000513486.1, ENST00000697932.1
      Conserved Domains (1) summary
      cd06450
      Location:144507
      DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      71685701..71750988
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367103.1XP_054223078.1  sphingosine-1-phosphate lyase 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBD4, O95470, Q7Z732, Q9ULG8, Q9UN89
    2. XM_054367104.1XP_054223079.1  sphingosine-1-phosphate lyase 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBD4, O95470, Q7Z732, Q9ULG8, Q9UN89
    3. XM_054367105.1XP_054223080.1  sphingosine-1-phosphate lyase 1 isoform X2

      UniProtKB/TrEMBL
      A0A8V8TN35
    4. XM_054367106.1XP_054223081.1  sphingosine-1-phosphate lyase 1 isoform X3

    5. XM_054367102.1XP_054223077.1  sphingosine-1-phosphate lyase 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBD4, O95470, Q7Z732, Q9ULG8, Q9UN89
    6. XM_054367101.1XP_054223076.1  sphingosine-1-phosphate lyase 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBD4, O95470, Q7Z732, Q9ULG8, Q9UN89