TIAM1 TIAM Rac1 associated GEF 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TIAM1provided by HGNC
Official Full Name: TIAM Rac1 associated GEF 1provided by HGNC
Primary source: HGNC:HGNC:11805
See related: Ensembl:ENSG00000156299 MIM:600687; AllianceGenome:HGNC:11805
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NEDLDS; TIAM-1
Summary: This gene encodes a RAC1-specific guanine nucleotide exchange factor (GEF). GEFs mediate the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP). The binding of GTP induces a conformational change in RAC1 that allows downstream effectors to bind and transduce a signal. This gene thus regulates RAC1 signaling pathways that affect cell shape, migration, adhesion, growth, survival, and polarity, as well as influencing actin cytoskeletal formation, endocytosis, and membrane trafficking. This gene thus plays an important role in cell invasion, metastasis, and carcinogenesis. In addition to RAC1, the encoded protein activates additional Rho-like GTPases such as CDC42, RAC2, RAC3 and RHOA. This gene encodes multiple protein isoforms that experience a diverse array of intramolecular, protein-protein, and phosphorylation interactions as well as phosphoinositide binding. Both the longer and shorter isoforms have C-terminal Dbl homology (DH) and pleckstrin homology (PH) domains while only the longer isoforms of this gene have the N-terminal myristoylation site and the downstream N-terminal PH domain, ras-binding domain (RBD), and PSD-95/DlgA/ZO-1 (PDZ) domain. [provided by RefSeq, Jul 2017]
Expression: Broad expression in esophagus (RPKM 7.7), skin (RPKM 6.8) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 21q22.11

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	21	NC_000021.9 (31118418..31559087, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	21	NC_060945.1 (29486163..29927068, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	21	NC_000021.8 (32490736..32931400, complement)

Chromosome 21 - NC_000021.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tiam1 regulates proliferation, invasion, and differentiation in neuroblastoma through the Tiam1/Rac1 signaling pathway.
Title: Tiam1 regulates proliferation, invasion, and differentiation in neuroblastoma through the Tiam1/Rac1 signaling pathway.
Deficiency in SPOP-mediated ubiquitination and degradation of TIAM1 promotes gastric cancer progression.
Title: Deficiency in SPOP-mediated ubiquitination and degradation of TIAM1 promotes gastric cancer progression.
TIAM1 acts as an actin organization regulator to control adipose tissue-derived pericyte cell fate.
Title: TIAM1 acts as an actin organization regulator to control adipose tissue-derived pericyte cell fate.
A TIAM1-TRIM28 complex mediates epigenetic silencing of protocadherins to promote migration of lung cancer cells.
Title: A TIAM1-TRIM28 complex mediates epigenetic silencing of protocadherins to promote migration of lung cancer cells.
Upregulation of miR-22 alleviates oxygen-glucose deprivation/reperfusion-induced injury by targeting Tiam1 in SH-SY5Y cells.
Title: Upregulation of miR-22 alleviates oxygen-glucose deprivation/reperfusion-induced injury by targeting Tiam1 in SH-SY5Y cells.
miR-21-5p/Tiam1-mediated glycolysis reprogramming drives breast cancer progression via enhancing PFKL stabilization.
Title: miR-21-5p/Tiam1-mediated glycolysis reprogramming drives breast cancer progression via enhancing PFKL stabilization.
Fibulin-3 sponges Tiam1 to manipulate MMP-7 activity through beta-catenin signaling in oral squamous cell carcinoma.
Title: Fibulin-3 sponges Tiam1 to manipulate MMP-7 activity through β-catenin signaling in oral squamous cell carcinoma.
TIAM1-RAC1 promote small-cell lung cancer cell survival through antagonizing Nur77-induced BCL2 conformational change.
Title: TIAM1-RAC1 promote small-cell lung cancer cell survival through antagonizing Nur77-induced BCL2 conformational change.
Whole Genome Sequencing Prioritizes CHEK2, EWSR1, and TIAM1 as Possible Predisposition Genes for Familial Non-Medullary Thyroid Cancer.
Title: Whole Genome Sequencing Prioritizes CHEK2, EWSR1, and TIAM1 as Possible Predisposition Genes for Familial Non-Medullary Thyroid Cancer.
Identification of Rac guanine nucleotide exchange factors promoting Lgl1 phosphorylation in glioblastoma.
Title: Identification of Rac guanine nucleotide exchange factors promoting Lgl1 phosphorylation in glioblastoma.

Submit: New GeneRIF Correction See all GeneRIFs (120)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Neurodevelopmental disorder with language delay and seizures MedGen: C5676998 OMIM: 619908 GeneReviews: Not available	not available

EBI GWAS Catalog

Description
Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. EBI GWAS Catalog EBI GWAS CatalogPubMed
Heritability and genome-wide association analysis of renal sinus fat accumulation in the Framingham Heart Study. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-150949 (e-PCR)
- UniSTS:173338

RH123331 (e-PCR)
- UniSTS:135708

SHGC-87547 (e-PCR)
- UniSTS:40239

D8S2279 (e-PCR)
- UniSTS:473907

SHGC-6822 (e-PCR)
- UniSTS:84022

RH123879 (e-PCR)
- UniSTS:136254

TIAM1 (e-PCR)
- UniSTS:506184

TIAM1_7227 (e-PCR)
- UniSTS:466508

D21S1862 (e-PCR)
- UniSTS:22115

NIB1194 (e-PCR)
- UniSTS:21349

RH48581 (e-PCR)
- UniSTS:37225

D21S1681 (e-PCR)
- UniSTS:150391

SHGC-51891 (e-PCR)
- UniSTS:33407

RH122439 (e-PCR)
- UniSTS:135310

D11S3114 (e-PCR)
- UniSTS:152207

SHGC-81220 (e-PCR)
- UniSTS:102038

SHGC-170078 (e-PCR)
- UniSTS:173728

SHGC-30615 (e-PCR)
- UniSTS:56228

D21S1854 (e-PCR)
- UniSTS:8119

SHGC-170314 (e-PCR)
- UniSTS:173770

SHGC-170316 (e-PCR)
- UniSTS:173771

D21S1909 (e-PCR), detects polymorphism
- UniSTS:39372

D21S2049 (e-PCR)
- UniSTS:69840

G34727 (e-PCR)
- UniSTS:6361

D21S1280 (e-PCR)
- UniSTS:148705

HSC1YE072 (e-PCR)
- UniSTS:69861

D21S305 (e-PCR)
- UniSTS:147689

D21S310 (e-PCR)
- UniSTS:147694

RH68783 (e-PCR)
- UniSTS:44798

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	EXP Inferred from Experiment more info	PubMed
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables guanyl-nucleotide exchange factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables guanyl-nucleotide exchange factor activity	TAS Traceable Author Statement more info
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor tyrosine kinase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Rac protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in Rac protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Wnt signaling pathway, planar cell polarity pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in activation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in cardiac muscle hypertrophy	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ephrin receptor signaling pathway	TAS Traceable Author Statement more info
involved_in neuron projection extension	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of Schwann cell chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of dendritic spine morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epithelial to mesenchymal transition	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of protein binding	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to membrane	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in regulation of dopaminergic neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of epithelial to mesenchymal transition	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info
involved_in regulation of modification of postsynaptic actin cytoskeleton	IEA Inferred from Electronic Annotation more info
involved_in regulation of non-canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of small GTPase mediated signal transduction	TAS Traceable Author Statement more info
involved_in response to cocaine	IEA Inferred from Electronic Annotation more info
involved_in small GTPase-mediated signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in axonal growth cone	IEA Inferred from Electronic Annotation more info
located_in cell-cell contact zone	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in extrinsic component of postsynaptic density membrane	IEA Inferred from Electronic Annotation more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in main axon	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle membrane	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: rho guanine nucleotide exchange factor TIAM1

Names: T cell lymphoma invasion and metastasis 1; T-lymphoma invasion and metastasis-inducing protein 1; human T-lymphoma invasion and metastasis inducing TIAM1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001353684.2 → NP_001340613.1 rho guanine nucleotide exchange factor TIAM1 isoform 2

Status: REVIEWED

Source sequence(s)

AP000246

Consensus CDS

CCDS86983.1

UniProtKB/TrEMBL

A0A1B0GW57

Related

ENSP00000490786.1, ENST00000636887.1

Conserved Domains (2) summary

smart00325
Location:77 → 266

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd01255
Location:268 → 439

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
NM_001353685.2 → NP_001340614.1 rho guanine nucleotide exchange factor TIAM1 isoform 3

Status: REVIEWED

Source sequence(s)

AP000246

Conserved Domains (2) summary

smart00325
Location:52 → 241

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd01255
Location:243 → 414

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
NM_001353686.2 → NP_001340615.1 rho guanine nucleotide exchange factor TIAM1 isoform 4

Status: REVIEWED

Source sequence(s)

AP000246, AP000247, AP000248

Conserved Domains (5) summary

cd01818
Location:766 → 841

TIAM1_RBD; Ubiquitin domain of Tiam1 guanine nucleotide exchange factor

smart00325
Location:1019 → 1208

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:846 → 925

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:432 → 558

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1210 → 1381

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
NM_001353687.2 → NP_001340616.1 rho guanine nucleotide exchange factor TIAM1 isoform 5

Status: REVIEWED

Source sequence(s)

AP000246, AP000247, AP000248

Related

ENSP00000388217.2, ENST00000455508.2

Conserved Domains (5) summary

cd01818
Location:741 → 816

TIAM1_RBD; Ubiquitin domain of Tiam1 guanine nucleotide exchange factor

smart00325
Location:1019 → 1208

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:821 → 900

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:432 → 558

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1210 → 1381

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
NM_001353688.1 → NP_001340617.1 rho guanine nucleotide exchange factor TIAM1 isoform 1

Status: REVIEWED

Source sequence(s)

AP000246, AP000247, AP000248, AP000251, AP000563

Consensus CDS

CCDS13609.1

UniProtKB/Swiss-Prot

B7ZLR6, F5GZ53, Q13009, Q17RT7

UniProtKB/TrEMBL

A0A2X0TW27

Conserved Domains (6) summary

smart00325
Location:1044 → 1233

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:846 → 925

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:432 → 558

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1235 → 1406

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

pfam02196
Location:766 → 835

RBD; Raf-like Ras-binding domain

pfam18385
Location:572 → 669

Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
NM_001353689.1 → NP_001340618.1 rho guanine nucleotide exchange factor TIAM1 isoform 1

Status: REVIEWED

Source sequence(s)

AP000246, AP000247, AP000248, AP000251, AP000563

Consensus CDS

CCDS13609.1

UniProtKB/Swiss-Prot

B7ZLR6, F5GZ53, Q13009, Q17RT7

UniProtKB/TrEMBL

A0A2X0TW27

Conserved Domains (6) summary

smart00325
Location:1044 → 1233

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:846 → 925

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:432 → 558

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1235 → 1406

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

pfam02196
Location:766 → 835

RBD; Raf-like Ras-binding domain

pfam18385
Location:572 → 669

Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
NM_001353690.1 → NP_001340619.1 rho guanine nucleotide exchange factor TIAM1 isoform 1

Status: REVIEWED

Source sequence(s)

AP000246, AP000247, AP000248, AP000251

Consensus CDS

CCDS13609.1

UniProtKB/Swiss-Prot

B7ZLR6, F5GZ53, Q13009, Q17RT7

UniProtKB/TrEMBL

A0A2X0TW27

Conserved Domains (6) summary

smart00325
Location:1044 → 1233

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:846 → 925

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:432 → 558

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1235 → 1406

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

pfam02196
Location:766 → 835

RBD; Raf-like Ras-binding domain

pfam18385
Location:572 → 669

Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
NM_001353691.1 → NP_001340620.1 rho guanine nucleotide exchange factor TIAM1 isoform 1

Status: REVIEWED

Source sequence(s)

AP000246, AP000247, AP000248, AP000251, AP000563

Consensus CDS

CCDS13609.1

UniProtKB/Swiss-Prot

B7ZLR6, F5GZ53, Q13009, Q17RT7

UniProtKB/TrEMBL

A0A2X0TW27

Conserved Domains (6) summary

smart00325
Location:1044 → 1233

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:846 → 925

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:432 → 558

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1235 → 1406

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

pfam02196
Location:766 → 835

RBD; Raf-like Ras-binding domain

pfam18385
Location:572 → 669

Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
NM_001353692.1 → NP_001340621.1 rho guanine nucleotide exchange factor TIAM1 isoform 1

Status: REVIEWED

Source sequence(s)

AP000246, AP000247, AP000248, AP000251, AP000563

Consensus CDS

CCDS13609.1

UniProtKB/Swiss-Prot

B7ZLR6, F5GZ53, Q13009, Q17RT7

UniProtKB/TrEMBL

A0A2X0TW27

Conserved Domains (6) summary

smart00325
Location:1044 → 1233

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:846 → 925

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:432 → 558

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1235 → 1406

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

pfam02196
Location:766 → 835

RBD; Raf-like Ras-binding domain

pfam18385
Location:572 → 669

Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
NM_001353693.1 → NP_001340622.1 rho guanine nucleotide exchange factor TIAM1 isoform 1

Status: REVIEWED

Source sequence(s)

AP000246, AP000247, AP000248, AP000251, AP000563

Consensus CDS

CCDS13609.1

UniProtKB/Swiss-Prot

B7ZLR6, F5GZ53, Q13009, Q17RT7

UniProtKB/TrEMBL

A0A2X0TW27

Conserved Domains (6) summary

smart00325
Location:1044 → 1233

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:846 → 925

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:432 → 558

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1235 → 1406

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

pfam02196
Location:766 → 835

RBD; Raf-like Ras-binding domain

pfam18385
Location:572 → 669

Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
NM_001353694.2 → NP_001340623.1 rho guanine nucleotide exchange factor TIAM1 isoform 1

Status: REVIEWED

Source sequence(s)

AP000246, AP000247, AP000248

Consensus CDS

CCDS13609.1

UniProtKB/Swiss-Prot

B7ZLR6, F5GZ53, Q13009, Q17RT7

UniProtKB/TrEMBL

A0A2X0TW27

Related

ENSP00000441570.2, ENST00000541036.6

Conserved Domains (6) summary

smart00325
Location:1044 → 1233

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:846 → 925

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:432 → 558

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1235 → 1406

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

pfam02196
Location:766 → 835

RBD; Raf-like Ras-binding domain

pfam18385
Location:572 → 669

Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
NM_003253.3 → NP_003244.2 rho guanine nucleotide exchange factor TIAM1 isoform 1

See identical proteins and their annotated locations for NP_003244.2

Status: REVIEWED

Source sequence(s)

AP000246, AP000247, AP000248, AP000251, AP000563

Consensus CDS

CCDS13609.1

UniProtKB/Swiss-Prot

B7ZLR6, F5GZ53, Q13009, Q17RT7

UniProtKB/TrEMBL

A0A2X0TW27

Related

ENSP00000286827.3, ENST00000286827.7

Conserved Domains (6) summary

smart00325
Location:1044 → 1233

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:846 → 925

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:432 → 558

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1235 → 1406

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

pfam02196
Location:766 → 835

RBD; Raf-like Ras-binding domain

pfam18385
Location:572 → 669

Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000021.9 Reference GRCh38.p14 Primary Assembly

Range

31118418..31559087 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047440969.1 → XP_047296925.1 rho guanine nucleotide exchange factor TIAM1 isoform X1

UniProtKB/Swiss-Prot

B7ZLR6, F5GZ53, Q13009, Q17RT7

UniProtKB/TrEMBL

A0A2X0TW27
XM_005261040.3 → XP_005261097.1 rho guanine nucleotide exchange factor TIAM1 isoform X2

UniProtKB/TrEMBL

A0A8V8TN84

Related

ENSP00000513591.1, ENST00000698169.1

Conserved Domains (6) summary

smart00325
Location:1044 → 1233

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:846 → 925

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:432 → 558

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1235 → 1406

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

pfam00169
Location:445 → 547

PH; PH domain

cl00155
Location:766 → 841

UBQ; Ubiquitin-like proteins

Alternate T2T-CHM13v2.0

Genomic

NC_060945.1 Alternate T2T-CHM13v2.0

Range

29486163..29927068 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054324807.1 → XP_054180782.1 rho guanine nucleotide exchange factor TIAM1 isoform X1
XM_054324808.1 → XP_054180783.1 rho guanine nucleotide exchange factor TIAM1 isoform X2

UniProtKB/TrEMBL

A0A8V8TN84