U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    TRMT61A tRNA methyltransferase 61A [ Homo sapiens (human) ]

    Gene ID: 115708, updated on 9-Dec-2024

    Summary

    Official Symbol
    TRMT61Aprovided by HGNC
    Official Full Name
    tRNA methyltransferase 61Aprovided by HGNC
    Primary source
    HGNC:HGNC:23790
    See related
    Ensembl:ENSG00000166166 MIM:620885; AllianceGenome:HGNC:23790
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GCD14; TRM61; Gcd14p; hTRM61; C14orf172
    Summary
    Enables mRNA (adenine-N1-)-methyltransferase activity. Involved in mRNA processing. Part of tRNA (m1A) methyltransferase complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in endometrium (RPKM 4.4), prostate (RPKM 4.3) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TRMT61A in Genome Data Viewer
    Location:
    14q32.33
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (103529196..103537073)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (97765240..97773117)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (103995533..104003410)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103984081-103984968 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103986745-103987632 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6155 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103989409-103990294 Neighboring gene creatine kinase B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6157 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6158 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103999205-103999704 Neighboring gene uncharacterized LOC124903392 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:104008443-104009162 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:104009885-104010606 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6159 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9105 Neighboring gene RNA, U7 small nuclear 160 pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:104027599-104028112 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9106 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6160 Neighboring gene BAG cochaperone 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ40452

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables mRNA (adenine-N1-)-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables tRNA (adenine(58)-N1)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in mRNA processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of tRNA (m1A) methyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of tRNA (m1A) methyltransferase complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A
    Names
    mRNA methyladenosine-N(1)-methyltransferase catalytic subunit TRMT61A
    tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRM61
    tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRMT61A
    tRNA methyltransferase 61 homolog A
    tRNA(m1A58)-methyltransferase subunit TRM61
    tRNA(m1A58)-methyltransferase subunit TRMT61A
    tRNA(m1A58)MTase subunit TRM61
    tRNA(m1A58)MTase subunit TRMT61A
    NP_689520.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152307.3NP_689520.2  tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A

      Status: VALIDATED

      Source sequence(s)
      AL133367, AL139300
      Consensus CDS
      CCDS41994.1
      UniProtKB/Swiss-Prot
      A6NN78, Q8N7Q9, Q96FX7
      Related
      ENSP00000374399.4, ENST00000389749.9
      Conserved Domains (2) summary
      pfam08704
      Location:64286
      GCD14; tRNA methyltransferase complex GCD14 subunit
      pfam14801
      Location:2358
      GCD14_N; tRNA methyltransferase complex GCD14 subunit N-term

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      103529196..103537073
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      97765240..97773117
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)