U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    COMMD7 COMM domain containing 7 [ Homo sapiens (human) ]

    Gene ID: 149951, updated on 3-Dec-2024

    Summary

    Official Symbol
    COMMD7provided by HGNC
    Official Full Name
    COMM domain containing 7provided by HGNC
    Primary source
    HGNC:HGNC:16223
    See related
    Ensembl:ENSG00000149600 MIM:616703; AllianceGenome:HGNC:16223
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C20orf92; dJ1085F17.3
    Summary
    Enables NF-kappaB binding activity. Involved in negative regulation of DNA-templated transcription; negative regulation of NF-kappaB transcription factor activity; and tumor necrosis factor-mediated signaling pathway. Predicted to be located in cytoplasmic vesicle and membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 17.9), placenta (RPKM 13.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See COMMD7 in Genome Data Viewer
    Location:
    20q11.21
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (32702699..32743467, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (34431363..34470209, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (31290501..31331273, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr20:31226322-31226509 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31226763-31227262 Neighboring gene chromosome 20 open reading frame 203 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31235460-31235960 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31235961-31236461 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17719 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12805 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31252264-31252832 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31252833-31253400 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31254622-31255122 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31259991-31260490 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17721 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31263362-31264064 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31266424-31267023 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31267024-31267622 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31267623-31268222 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr20:31268822-31269421 and GRCh37_chr20:31269422-31270020 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31271401-31271902 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31271903-31272402 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31274017-31274656 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31277881-31278443 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:31290694-31291210 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31293307-31294054 Neighboring gene BCL2 antagonist/killer 1 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31296664-31297170 Neighboring gene Sharpr-MPRA regulatory region 13573 Neighboring gene OCT4 hESC enhancer GRCh37_chr20:31310141-31310642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31310711-31311220 Neighboring gene Sharpr-MPRA regulatory region 10337 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31320600-31321468 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31321469-31322336 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31324911-31325766 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:31326137-31326302 Neighboring gene OCT4 hESC enhancer GRCh37_chr20:31328938-31329439 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:31329890-31330064 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31330109-31330936 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12806 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12807 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr20:31331824-31332768 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr20:31334657-31335599 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31336541-31337182 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31337183-31337824 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31337825-31338466 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31338467-31339107 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr20:31339333-31339906 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31339907-31340480 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31340481-31341054 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31343273-31344259 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31344260-31345245 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31347799-31348347 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31348348-31348895 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31349119-31349784 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12808 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12809 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr20:31351780-31352445 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31353111-31353775 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31353776-31354439 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31355267-31355868 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31355869-31356470 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31358045-31358546 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31361516-31362222 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31362928-31363633 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31365281-31365829 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31365865-31366366 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31366868-31367368 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31367369-31367869 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31367870-31368371 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31368372-31368872 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31368873-31369873 Neighboring gene DNA methyltransferase 3 beta Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31374779-31375450 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr20:31375451-31376121 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31377111-31378042 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr20:31378043-31378972 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr20:31385992-31387191 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31388345-31389148 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31389149-31389952 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31391821-31392634 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31394723-31395522 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31395523-31396320 Neighboring gene OCT4 hESC enhancer GRCh37_chr20:31397487-31397988 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12810 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31408139-31408808 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31408809-31409478 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31420386-31420886 Neighboring gene microtubule associated protein RP/EB family member 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31428835-31429334

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    COMM domain-containing protein 7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099339.2NP_001092809.1  COMM domain-containing protein 7 isoform 2

      See identical proteins and their annotated locations for NP_001092809.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2).
      Source sequence(s)
      AK027893, BQ006261, DN993528
      Consensus CDS
      CCDS46587.1
      UniProtKB/TrEMBL
      A0A2R8Y620
      Related
      ENSP00000395339.1, ENST00000446419.6
      Conserved Domains (1) summary
      cd04755
      Location:19197
      Commd7; COMM_Domain containing protein 7. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...
    2. NM_053041.3NP_444269.2  COMM domain-containing protein 7 isoform 1

      See identical proteins and their annotated locations for NP_444269.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK027893, BG715846, BQ006261
      Consensus CDS
      CCDS42864.1
      UniProtKB/Swiss-Prot
      A2BHJ2, B3KTZ2, Q5JYB0, Q86VX2, Q96SI7, Q9BW53
      UniProtKB/TrEMBL
      A0A2R8Y620
      Related
      ENSP00000278980.6, ENST00000278980.11
      Conserved Domains (1) summary
      cd04755
      Location:19198
      Commd7; COMM_Domain containing protein 7. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      32702699..32743467 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047439932.1XP_047295888.1  COMM domain-containing protein 7 isoform X6

    2. XM_017027685.3XP_016883174.1  COMM domain-containing protein 7 isoform X4

      UniProtKB/TrEMBL
      A0A2R8Y620
    3. XM_017027686.3XP_016883175.1  COMM domain-containing protein 7 isoform X5

    4. XM_011528604.4XP_011526906.1  COMM domain-containing protein 7 isoform X3

      UniProtKB/TrEMBL
      A0A2R8Y620
      Conserved Domains (1) summary
      cd04755
      Location:19175
      Commd7; COMM_Domain containing protein 7. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...
    5. XM_005260300.5XP_005260357.1  COMM domain-containing protein 7 isoform X2

      Conserved Domains (1) summary
      cd04755
      Location:19174
      Commd7; COMM_Domain containing protein 7. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...
    6. XM_005260299.5XP_005260356.1  COMM domain-containing protein 7 isoform X1

      Conserved Domains (1) summary
      cd04755
      Location:19175
      Commd7; COMM_Domain containing protein 7. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      34431363..34470209 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054323085.1XP_054179060.1  COMM domain-containing protein 7 isoform X6

    2. XM_054323083.1XP_054179058.1  COMM domain-containing protein 7 isoform X4

      UniProtKB/TrEMBL
      A0A2R8Y620
    3. XM_054323084.1XP_054179059.1  COMM domain-containing protein 7 isoform X5

    4. XM_054323082.1XP_054179057.1  COMM domain-containing protein 7 isoform X3

      UniProtKB/TrEMBL
      A0A2R8Y620
    5. XM_054323081.1XP_054179056.1  COMM domain-containing protein 7 isoform X2

    6. XM_054323080.1XP_054179055.1  COMM domain-containing protein 7 isoform X1