TMSB15A thymosin beta 15A [Homo sapiens (human)] - Gene

Summary

Official Symbol: TMSB15Aprovided by HGNC
Official Full Name: thymosin beta 15Aprovided by HGNC
Primary source: HGNC:HGNC:30744
See related: Ensembl:ENSG00000158164 MIM:300939; AllianceGenome:HGNC:30744
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: Tb15; TbNB; TMSL8; TMSNB; TMSB15; TMSB15B
Summary: Predicted to enable actin monomer binding activity. Involved in positive regulation of cell migration. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in prostate (RPKM 5.7), endometrium (RPKM 2.4) and 14 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: Xq22.1

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (102513682..102516739, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (100958170..100961227, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (101768610..101771667, complement)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Thymosin beta 15A (TMSB15A) is a predictor of chemotherapy response in triple-negative breast cancer.
Title: Thymosin beta 15A (TMSB15A) is a predictor of chemotherapy response in triple-negative breast cancer.
Thymosin beta15 (Tbeta15) was translocated into nuclei following kainic acid (KA) treatments in a subset of entorhinal cortex neurons which are the population that undergo delayed apoptosis after KA treatment.
Title: Expression and subcellular localization of thymosin beta15 following kainic acid treatment in rat brain.
Our data show that the TMSB15A and TMSB15B isoforms have distinct expression patterns in different tumor cell lines and tissues.
Title: Differential regulation of human thymosin beta 15 isoforms by transforming growth factor beta 1.
findings suggest that increased thymosin beta15 expression correlates with the progression and metastasis of non-small cell lung cancer
Title: Elevated thymosin beta15 expression is associated with progression and metastasis of non-small cell lung cancer.
TMSL8 is well conserved in many mammalian species. Two isoforms, thymosin beta15a and b, exist at different locations, 1.4Mb apart, on human chromosome X, with 98% identity across the coding sequences.
Title: Thymosin beta-NB is the human isoform of rat thymosin beta15.
Identification of thymosin beta15, the rat homolog of human thymosin beta 15/thymosin beta NB/thymosin-like 8. Thymosin beta15 levels increase in human prostate cancer, correlating positively with Gleason tumor grade.
Title: Thymosin beta 15: a novel regulator of tumor cell motility upregulated in metastatic prostate cancer.
Human thymosin beta neuroblastoma has a higher affinity for actin in comparison to thymosin beta4 and promotes cell migration.
Title: Functional and profiling studies prove that prostate cancer upregulated neuroblastoma thymosin beta is the true human homologue of rat thymosin beta15.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH80772 (e-PCR)
- UniSTS:85563

SHGC-57323 (e-PCR)
- UniSTS:1478

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables actin monomer binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in sequestering of actin monomers	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: thymosin beta-15A

Names: NB thymosin beta; Thymosin beta-15B; thymosin, beta, identified in neuroblastoma cells; thymosin-like 8; thymosin-like protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.