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    SMIM10L2A small integral membrane protein 10 like 2A [ Homo sapiens (human) ]

    Gene ID: 399668, updated on 17-Sep-2024

    Summary

    Official Symbol
    SMIM10L2Aprovided by HGNC
    Official Full Name
    small integral membrane protein 10 like 2Aprovided by HGNC
    Primary source
    HGNC:HGNC:34499
    See related
    Ensembl:ENSG00000178947 AllianceGenome:HGNC:34499
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LED; LINC0086; LINC00086; LINC00087; SMIM10L2B; NCRNA00086; NCRNA00087
    Summary
    This gene encodes a highly conserved small protein that contains a conserved motif (DUF4560) and may function as an integral membrane protein. This transcript was also shown to associate with enhancer chromatin and therefore may also function as an RNA to regulate enhancers. [provided by RefSeq, Jan 2017]
    Expression
    Biased expression in adrenal (RPKM 10.3), brain (RPKM 9.2) and 13 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See SMIM10L2A in Genome Data Viewer
    Location:
    Xq26.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (135421944..135428075)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (133747687..133753818)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (134555869..134562000)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21019 Neighboring gene zinc finger protein 449 Neighboring gene uncharacterized LOC100506790 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:134539161-134540038 Neighboring gene NANOG hESC enhancer GRCh37_chrX:134542673-134543175 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21020 Neighboring gene RNA, 5S ribosomal pseudogene 515 Neighboring gene CROCC pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    small integral membrane protein 10-like protein 2A
    Names
    Small integral membrane protein 10-like protein 2B
    lncRNA activator of enhancer domains
    long intergenic non-protein coding RNA 86

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_203306.3NP_976051.1  small integral membrane protein 10-like protein 2A

      Status: VALIDATED

      Source sequence(s)
      AL450472
      UniProtKB/Swiss-Prot
      P0DMW4, P0DMW5
      Related
      ENSP00000488643.1, ENST00000417443.3
      Conserved Domains (1) summary
      pfam15118
      Location:2177
      DUF4560; Domain of unknown function (DUF4560)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      135421944..135428075
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      133747687..133753818
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)