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    CTXN2 cortexin 2 [ Homo sapiens (human) ]

    Gene ID: 399697, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CTXN2provided by HGNC
    Official Full Name
    cortexin 2provided by HGNC
    Primary source
    HGNC:HGNC:31109
    See related
    Ensembl:ENSG00000233932 AllianceGenome:HGNC:31109
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to be located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
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    Genomic context

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    See CTXN2 in Genome Data Viewer
    Location:
    15q21.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (48178438..48203758)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (45986536..46011849)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (48470635..48495955)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903485 Neighboring gene solute carrier family 24 member 5 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:48442018-48442582 Neighboring gene myelin expression factor 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6412 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6413 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:48470436-48471087 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:48483866-48484369 Neighboring gene CTXN2 antisense RNA 1 Neighboring gene solute carrier family 12 member 1 Neighboring gene uncharacterized LOC128966560 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:48543423-48544622 Neighboring gene MPRA-validated peak2328 silencer Neighboring gene uncharacterized LOC124903486 Neighboring gene DUT antisense RNA 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Analysis of the DNA sequence and duplication history of human chromosome 15. Zody MC, et al. Nature, 2006 Mar 30. PMID 16572171

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Homology

    Clone Names

    • DKFZp781M2440

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cortexin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145668.2 → NP_001139140.1  cortexin-2

      See identical proteins and their annotated locations for NP_001139140.1

      Status: VALIDATED

      Source sequence(s)
      AC066612, BX537772
      Consensus CDS
      CCDS45254.1
      UniProtKB/Swiss-Prot
      P0C2S0
      Related
      ENSP00000406145.2, ENST00000417307.3
      Conserved Domains (1) summary
      pfam11057
      Location:9 → 81
      Cortexin; Cortexin of kidney

    2. NM_001370415.1 → NP_001357344.1  cortexin-2

      Status: VALIDATED

      Source sequence(s)
      AC066612
      Consensus CDS
      CCDS45254.1
      UniProtKB/Swiss-Prot
      P0C2S0
      Related
      ENSP00000495979.1, ENST00000645050.1
      Conserved Domains (1) summary
      pfam11057
      Location:9 → 81
      Cortexin; Cortexin of kidney

    3. NM_001370416.1 → NP_001357345.1  cortexin-2

      Status: VALIDATED

      Source sequence(s)
      AC066612
      Consensus CDS
      CCDS45254.1
      UniProtKB/Swiss-Prot
      P0C2S0
      Related
      ENSP00000493942.1, ENST00000647363.1
      Conserved Domains (1) summary
      pfam11057
      Location:9 → 81
      Cortexin; Cortexin of kidney

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      48178438..48203758
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047432494.1 → XP_047288450.1  cortexin-2 isoform X1

      UniProtKB/Swiss-Prot
      P0C2S0
      Related
      ENSP00000495988.1, ENST00000644354.1

    2. XM_017022178.2 → XP_016877667.1  cortexin-2 isoform X1

      UniProtKB/Swiss-Prot
      P0C2S0
      Conserved Domains (1) summary
      pfam11057
      Location:9 → 81
      Cortexin; Cortexin of kidney

    3. XM_006720504.3 → XP_006720567.1  cortexin-2 isoform X1

      See identical proteins and their annotated locations for XP_006720567.1

      UniProtKB/Swiss-Prot
      P0C2S0
      Conserved Domains (1) summary
      pfam11057
      Location:9 → 81
      Cortexin; Cortexin of kidney

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      45986536..46011849
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054377899.1 → XP_054233874.1  cortexin-2 isoform X1

      UniProtKB/Swiss-Prot
      P0C2S0

    2. XM_054377898.1 → XP_054233873.1  cortexin-2 isoform X1

      UniProtKB/Swiss-Prot
      P0C2S0

    3. XM_054377900.1 → XP_054233875.1  cortexin-2 isoform X1

      UniProtKB/Swiss-Prot
      P0C2S0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C2S0.1 GenPept UniProtKB/Swiss-Prot:P0C2S0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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