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    B3galnt1 UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 1 [ Mus musculus (house mouse) ]

    Gene ID: 26879, updated on 28-Oct-2024

    Summary

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    Official Symbol
    B3galnt1provided by MGI
    Official Full Name
    UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 1provided by MGI
    Primary source
    MGI:MGI:1349405
    See related
    Ensembl:ENSMUSG00000043300 AllianceGenome:MGI:1349405
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    b3GT3; Mbrn 1; B3galt3; b3Gal-T3; beta3GalT3; beta-3-Gx-T3
    Summary
    Enables UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity. Acts upstream of or within oligosaccharide biosynthetic process. Predicted to be active in Golgi membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human B3GALNT1 (beta-1,3-N-acetylgalactosaminyltransferase 1 (Globoside blood group)). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in CNS E18 (RPKM 14.0), whole brain E14.5 (RPKM 8.9) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See B3galnt1 in Genome Data Viewer
    Location:
    3 E1; 3 32.24 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (69481252..69506305, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (69573919..69598960, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1 (formerly 2C)-like Neighboring gene STARR-positive B cell enhancer ABC_E3437 Neighboring gene STARR-seq mESC enhancer starr_07923 Neighboring gene predicted gene, 52607 Neighboring gene STARR-seq mESC enhancer starr_07924 Neighboring gene STARR-seq mESC enhancer starr_07925 Neighboring gene STARR-seq mESC enhancer starr_07926 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_07927 Neighboring gene STARR-seq mESC enhancer starr_07928 Neighboring gene STARR-seq mESC enhancer starr_07930 Neighboring gene predicted gene, 57714 Neighboring gene ribosomal protein L32, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A murine homologue of the Drosophila brainiac gene shows homology to glycosyltransferases and is required for preimplantation development of the mouse. Vollrath B, et al. Mol Cell Biol, 2001 Aug. PMID 11463849, Free PMC Article
    2. Murine glycosyltransferases responsible for the expression of globo-series glycolipids: cDNA structures, mRNA expression, and distribution of their products. Fujii Y, et al. Glycobiology, 2005 Dec. PMID 16079416
    3. Genomic cloning and expression of three murine UDP-galactose: beta-N-acetylglucosamine beta1,3-galactosyltransferase genes. Hennet T, et al. J Biol Chem, 1998 Jan 2. PMID 9417047
    4. Global gene expression analysis in fetal mouse ovaries with and without meiosis and comparison of selected genes with meiosis in the testis. Olesen C, et al. Cell Tissue Res, 2007 Apr. PMID 17431699
    5. A genetic approach to Mammalian glycan function. Lowe JB, et al. Annu Rev Biochem, 2003. PMID 12676797

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gb3 and Gb4 synthase are responsible for the expression of globo-series glycolipids
      Title: Murine glycosyltransferases responsible for the expression of globo-series glycolipids: cDNA structures, mRNA expression, and distribution of their products.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within oligosaccharide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1
    Names
    Brainiac 1
    Globoside blood group
    UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase III
    UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 3
    UDP-N-acetylgalactosamine:globotriaosylceramide beta-1,3-N-acetylgalactosaminyltransferase
    beta-1,3-GalNAc-T1
    beta-1,3-GalTase 3
    beta-1,3-galactosyltransferase 3
    galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferase
    globoside synthase
    NP_001397566.1
    NP_001397567.1
    NP_064410.1
    XP_036019016.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410637.1 → NP_001397566.1  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1

      Status: VALIDATED

      Source sequence(s)
      AC111096
      UniProtKB/Swiss-Prot
      O54906, Q91V72, Q920V0, Q920V1, Q9CTE5

    2. NM_001410638.1 → NP_001397567.1  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1

      Status: VALIDATED

      Source sequence(s)
      AC111096
      UniProtKB/Swiss-Prot
      O54906, Q91V72, Q920V0, Q920V1, Q9CTE5

    3. NM_020026.5 → NP_064410.1  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1

      See identical proteins and their annotated locations for NP_064410.1

      Status: VALIDATED

      Source sequence(s)
      AC111096
      Consensus CDS
      CCDS17406.1
      UniProtKB/Swiss-Prot
      O54906, Q91V72, Q920V0, Q920V1, Q9CTE5
      Related
      ENSMUSP00000058363.2, ENSMUST00000061826.3
      Conserved Domains (1) summary
      pfam01762
      Location:92 → 285
      Galactosyl_T; Galactosyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      69481252..69506305 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163123.1 → XP_036019016.1  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      O54906, Q91V72, Q920V0, Q920V1, Q9CTE5
      Conserved Domains (1) summary
      pfam01762
      Location:92 → 285
      Galactosyl_T; Galactosyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q920V1.2 GenPept UniProtKB/Swiss-Prot:Q920V1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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