Itih5 inter-alpha-trypsin inhibitor, heavy chain 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Itih5provided by MGI
Official Full Name: inter-alpha-trypsin inhibitor, heavy chain 5provided by MGI
Primary source: MGI:MGI:1925751
See related: Ensembl:ENSMUSG00000025780 AllianceGenome:MGI:1925751
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: E130106B02; 4631408O11Rik; 5430408M01Rik
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in hyaluronan metabolic process and negative regulation of peptidase activity. Located in collagen-containing extracellular matrix. Is expressed in several structures, including genitourinary system; gut; limb segment; meninges; and sensory organ. Orthologous to human ITIH5 (inter-alpha-trypsin inhibitor heavy chain 5). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Broad expression in bladder adult (RPKM 41.5), subcutaneous fat pad adult (RPKM 34.7) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A1; 2 6.94 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (10158354..10261340)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (10153536..10256529)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic deletion of ITIH5 leads to increased development of adipose tissue in mice.
Title: Genetic deletion of ITIH5 leads to increased development of adipose tissue in mice.
Inter-alpha-Trypsin Inhibitor Heavy Chain 5 (ITIH5) Is a Natural Stabilizer of Hyaluronan That Modulates Biological Processes in the Skin.
Title: Inter-α-Trypsin Inhibitor Heavy Chain 5 (ITIH5) Is a Natural Stabilizer of Hyaluronan That Modulates Biological Processes in the Skin.
indicate an additional and specific role of this gene in the female reproductive tract, and furthermore reinforces ITIH5 as a putative candidate gene for MRKH syndrome.
Title: Involvement of ITIH5, a candidate gene for congenital uterovaginal aplasia (Mayer-Rokitansky-Küster-Hauser syndrome), in female genital tract development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fb20a06.x1 (e-PCR)
- UniSTS:190275

D2Mit31 (e-PCR), detects polymorphism
- UniSTS:129200

D2Mit31.1 (e-PCR), detects polymorphism
- UniSTS:129201

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in hyaluronan metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: inter-alpha-trypsin inhibitor heavy chain H5

Names: ITI heavy chain H5; ITI-HC5; inter-alpha (globulin) inhibitor H5; inter-alpha trypsin inhibitor heavy chain precursor 5; inter-alpha-inhibitor heavy chain 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172471.2 → NP_766059.1 inter-alpha-trypsin inhibitor heavy chain H5 precursor

See identical proteins and their annotated locations for NP_766059.1

Status: VALIDATED

Source sequence(s)

AK087428, AL953853, AW046694, BB595829

Consensus CDS

CCDS15678.1

UniProtKB/Swiss-Prot

Q3US68, Q80VG0, Q8BJD1

Related

ENSMUSP00000026886.8, ENSMUST00000026886.8

Conserved Domains (4) summary

cd01461
Location:292 → 473

vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...

TIGR03788
Location:65 → 620

marine_srt_targ; marine proteobacterial sortase target protein

pfam06668
Location:716 → 909

ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus

pfam08487
Location:51 → 157

VIT; Vault protein inter-alpha-trypsin domain