Prkd3 protein kinase D3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prkd3provided by MGI
Official Full Name: protein kinase D3provided by MGI
Primary source: MGI:MGI:1922542
See related: Ensembl:ENSMUSG00000024070 AllianceGenome:MGI:1922542
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PKD3; Pkcnu; Prkcn; 4930557O20Rik; 5730497N19Rik
Summary: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and phospholipase C-activating G protein-coupled receptor signaling pathway. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; brain; integumental system; musculoskeletal system; and retina. Orthologous to human PRKD3 (protein kinase D3). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 13.1), limb E14.5 (RPKM 11.2) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 E3; 17 49.69 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (79256834..79328245, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (78949405..79020816, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protein kinase D3 conditional knockout impairs osteoclast formation and increases trabecular bone volume in male mice.
Title: Protein kinase D3 conditional knockout impairs osteoclast formation and increases trabecular bone volume in male mice.
Protein kinase D3 promotes neutrophil migration during viral infection.
Title: Protein kinase D3 promotes neutrophil migration during viral infection.
T cell-intrinsic protein kinase D3 is dispensable for the cells' activation.
Title: T cell-intrinsic protein kinase D3 is dispensable for the cells' activation.
Addressing the role of PKD3 in the T cell compartment with knockout mice.
Title: Addressing the role of PKD3 in the T cell compartment with knockout mice.
A phosphoproteomic approach reveals that PKD3 controls PKA-mediated glucose and tyrosine metabolism.
Title: A phosphoproteomic approach reveals that PKD3 controls PKA-mediated glucose and tyrosine metabolism.
Deletion of Protein Kinase D3 Promotes Liver Fibrosis in Mice.
Title: Deletion of Protein Kinase D3 Promotes Liver Fibrosis in Mice.
Pancreas-specific deletion of protein kinase D attenuates inflammation, necrosis, and severity of acute pancreatitis.
Title: Pancreas-specific deletion of protein kinase D attenuates inflammation, necrosis, and severity of acute pancreatitis.
Inhibition of protein kinase D by CID755673 promotes maintenance of the pluripotency of embryonic stem cells.
Title: Inhibition of protein kinase D by CID755673 promotes maintenance of the pluripotency of embryonic stem cells.
The kinase PKD3 provides negative feedback on cholesterol and triglyceride synthesis by suppressing insulin signaling.
Title: The kinase PKD3 provides negative feedback on cholesterol and triglyceride synthesis by suppressing insulin signaling.
These data provide new insights of a specific PKD3 signaling pathway by identifying a new function, which has not been identified before.
Title: PKD3 deficiency causes alterations in microtubule dynamics during the cell cycle.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D17Mit72 (e-PCR), detects polymorphism
- UniSTS:116482

Prkcn (e-PCR), detects polymorphism
- UniSTS:480328

NoName (e-PCR)
- UniSTS:237703

MT1520 (e-PCR)
- UniSTS:127967

D17Mit142.2 (e-PCR), detects polymorphism
- UniSTS:127968

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables diacylglycerol-dependent serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein kinase D3

Names: nPKC-nu; protein kinase C nu type; protein kinase C, nu

NP_001164475.1

EC 2.7.11.13

NP_001164476.1

EC 2.7.11.13

NP_083515.2

EC 2.7.11.13

XP_030105983.1

EC 2.7.11.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001171004.1 → NP_001164475.1 serine/threonine-protein kinase D3 isoform 1

See identical proteins and their annotated locations for NP_001164475.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC151293, AC154274, BC089164

Consensus CDS

CCDS50185.1

UniProtKB/TrEMBL

Q5FWX6

Related

ENSMUSP00000113395.2, ENSMUST00000119284.8

Conserved Domains (6) summary

smart00220
Location:580 → 832

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00029
Location:272 → 321

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd01239
Location:410 → 534

PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain

cd14082
Location:572 → 831

STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D

pfam00130
Location:155 → 204

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam00169
Location:417 → 531

PH; PH domain
NM_001171005.1 → NP_001164476.1 serine/threonine-protein kinase D3 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AC151293, AC154274, AK030058

Consensus CDS

CCDS50184.1

UniProtKB/TrEMBL

D3Z6I0

Related

ENSMUSP00000113232.2, ENSMUST00000118768.8

Conserved Domains (6) summary

smart00220
Location:485 → 737

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00029
Location:177 → 226

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd01239
Location:315 → 439

PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain

cd14082
Location:477 → 736

STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D

pfam00130
Location:60 → 109

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam00169
Location:322 → 436

PH; PH domain
NM_029239.3 → NP_083515.2 serine/threonine-protein kinase D3 isoform 2

See identical proteins and their annotated locations for NP_083515.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AC151293, AC154274

Consensus CDS

CCDS37699.1

UniProtKB/Swiss-Prot

Q8K1Y2

Related

ENSMUSP00000132004.2, ENSMUST00000168887.8

Conserved Domains (6) summary

smart00220
Location:579 → 831

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00029
Location:272 → 321

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd01239
Location:410 → 534

PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain

cd14082
Location:571 → 830

STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D

pfam00130
Location:155 → 204

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam00169
Location:417 → 531

PH; PH domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

79256834..79328245 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030250123.2 → XP_030105983.1 serine/threonine-protein kinase D3 isoform X1

Conserved Domains (2) summary

cd01239
Location:10 → 134

PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain

cd14082
Location:172 → 431

STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D