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    Fbxo38 F-box protein 38 [ Mus musculus (house mouse) ]

    Gene ID: 107035, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Fbxo38provided by MGI
    Official Full Name
    F-box protein 38provided by MGI
    Primary source
    MGI:MGI:2444639
    See related
    Ensembl:ENSMUSG00000042211 AllianceGenome:MGI:2444639
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Moka; SP329; 6030410I24Rik
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; positive regulation of T cell mediated immune response to tumor cell; and protein K48-linked ubiquitination. Predicted to act upstream of or within positive regulation of neuron projection development. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; limb bud; retina; spleen; and testis. Human ortholog(s) of this gene implicated in autosomal dominant distal hereditary motor neuronopathy 6. Orthologous to human FBXO38 (F-box protein 38). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 5.6), testis adult (RPKM 4.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fbxo38 in Genome Data Viewer
    Location:
    18 E1; 18 35.11 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (62637130..62681934, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (62504059..62548863, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene 5 hydroxytryptamine (serotonin) receptor 4 Neighboring gene predicted gene, 36316 Neighboring gene X-linked lymphocyte-regulated 5C pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E967 Neighboring gene serine peptidase inhibitor, Kazal type 10 Neighboring gene STARR-seq mESC enhancer starr_44774 Neighboring gene serine peptidase inhibitor, Kazal type 7 (putative) Neighboring gene STARR-seq mESC enhancer starr_44775 Neighboring gene serine peptidase inhibitor, Kazal type 13 Neighboring gene STARR-seq mESC enhancer starr_44776 Neighboring gene predicted gene, 41751

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. FBXO38 Ubiquitin Ligase Controls Sertoli Cell Maturation. Dibus N, et al. Front Cell Dev Biol, 2022. PMID 35769260, Free PMC Article
    2. FBXO38 mediates FGL1 ubiquitination and degradation to enhance cancer immunity and suppress inflammation. Tian T, et al. Cell Rep, 2023 Nov 28. PMID 37938970
    3. Multiple pathways regulate intracellular shuttling of MoKA, a co-activator of transcription factor KLF7. Smaldone S, et al. Nucleic Acids Res, 2006. PMID 16990251, Free PMC Article
    4. FBXO38 is dispensable for PD-1 regulation. Dibus N, et al. EMBO Rep, 2024 Oct. PMID 39266770, Free PMC Article
    5. A dominant mutation in FBXO38 causes distal spinal muscular atrophy with calf predominance. Sumner CJ, et al. Am J Hum Genet, 2013 Nov 7. PMID 24207122, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FBXO38 is dispensable for PD-1 regulation.
      Title: FBXO38 is dispensable for PD-1 regulation.
    2. FBXO38 mediates FGL1 ubiquitination and degradation to enhance cancer immunity and suppress inflammation.
      Title: FBXO38 mediates FGL1 ubiquitination and degradation to enhance cancer immunity and suppress inflammation.
    3. data indicate that FBXO38 regulates PD-1 expression and highlight an alternative method to block the PD-1 pathway
      Title: FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells.
    4. MoKA and KLF7 interact functionally to regulate gene expression during cell differentiation
      Title: Identification of MoKA, a novel F-box protein that modulates Krüppel-like transcription factor 7 activity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-like ligase-substrate adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of T cell activation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of T cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of T cell mediated immune response to tumor cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of T cell mediated immune response to tumor cell ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    F-box only protein 38
    Names
    F-box protein modulating KLF7 activity
    modulator of KLF7 activity

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361088.1 → NP_001348017.1  F-box only protein 38 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC131714, AC165083
      Conserved Domains (1) summary
      pfam00646
      Location:30 → 65
      F-box; F-box domain

    2. NM_001361089.1 → NP_001348018.1  F-box only protein 38 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC131714, AC165083

    3. NM_001361090.1 → NP_001348019.1  F-box only protein 38 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC131714, AC165083
      Conserved Domains (1) summary
      pfam00646
      Location:32 → 65
      F-box; F-box domain

    4. NM_001361091.1 → NP_001348020.1  F-box only protein 38 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC131714, AC165083

    5. NM_134136.4 → NP_598897.2  F-box only protein 38 isoform 4

      See identical proteins and their annotated locations for NP_598897.2

      Status: VALIDATED

      Source sequence(s)
      AC131714, AC165083
      Consensus CDS
      CCDS37841.1
      UniProtKB/Swiss-Prot
      Q8BMI0, Q8BTQ4, Q8C0H4
      Related
      ENSMUSP00000047541.7, ENSMUST00000048688.8
      Conserved Domains (1) summary
      pfam00646
      Location:32 → 65
      F-box; F-box domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      62637130..62681934 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160927.1 → XP_036016820.1  F-box only protein 38 isoform X2

      Conserved Domains (1) summary
      pfam00646
      Location:32 → 65
      F-box; F-box domain

    2. XM_036160924.1 → XP_036016817.1  F-box only protein 38 isoform X1

      Conserved Domains (1) summary
      pfam00646
      Location:32 → 65
      F-box; F-box domain

    3. XM_036160926.1 → XP_036016819.1  F-box only protein 38 isoform X2

      Conserved Domains (1) summary
      pfam00646
      Location:32 → 65
      F-box; F-box domain

    4. XM_006525501.5 → XP_006525564.1  F-box only protein 38 isoform X5

      Conserved Domains (1) summary
      pfam00646
      Location:32 → 65
      F-box; F-box domain

    5. XM_036160929.1 → XP_036016822.1  F-box only protein 38 isoform X4

      Conserved Domains (1) summary
      pfam00646
      Location:32 → 65
      F-box; F-box domain

    6. XM_036160923.1 → XP_036016816.1  F-box only protein 38 isoform X1

      Conserved Domains (1) summary
      pfam00646
      Location:32 → 65
      F-box; F-box domain

    7. XM_030250266.2 → XP_030106126.1  F-box only protein 38 isoform X9

    8. XM_036160932.1 → XP_036016825.1  F-box only protein 38 isoform X7

    9. XM_030250265.2 → XP_030106125.1  F-box only protein 38 isoform X8

    10. XM_036160930.1 → XP_036016823.1  F-box only protein 38 isoform X6

    11. XM_036160925.1 → XP_036016818.1  F-box only protein 38 isoform X1

      Conserved Domains (1) summary
      pfam00646
      Location:32 → 65
      F-box; F-box domain

    12. XM_036160928.1 → XP_036016821.1  F-box only protein 38 isoform X2

      Conserved Domains (1) summary
      pfam00646
      Location:32 → 65
      F-box; F-box domain

    13. XM_030250263.2 → XP_030106123.1  F-box only protein 38 isoform X3

      UniProtKB/Swiss-Prot
      Q8BMI0, Q8BTQ4, Q8C0H4
      Conserved Domains (1) summary
      pfam00646
      Location:32 → 65
      F-box; F-box domain

    14. XM_030250264.2 → XP_030106124.1  F-box only protein 38 isoform X3

      UniProtKB/Swiss-Prot
      Q8BMI0, Q8BTQ4, Q8C0H4
      Conserved Domains (1) summary
      pfam00646
      Location:32 → 65
      F-box; F-box domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BMI0.1 GenPept UniProtKB/Swiss-Prot:Q8BMI0

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