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    Il17b interleukin 17B [ Mus musculus (house mouse) ]

    Gene ID: 56069, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Il17bprovided by MGI
    Official Full Name
    interleukin 17Bprovided by MGI
    Primary source
    MGI:MGI:1928397
    See related
    Ensembl:ENSMUSG00000024578 AllianceGenome:MGI:1928397
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zcyto7; 1110006O16Rik; 1700006N07Rik
    Summary
    Enables cytokine activity. Acts upstream of or within positive regulation of cytokine production involved in inflammatory response. Predicted to be located in extracellular space. Is expressed in several structures, including central nervous system; dorsal root ganglion; limb; limb bud; and trunk. Orthologous to human IL17B (interleukin 17B). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in limb E14.5 (RPKM 8.8), mammary gland adult (RPKM 3.7) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Il17b in Genome Data Viewer
    Location:
    18 E1; 18 34.67 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (61821006..61825609)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (61687935..61692538)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene microRNA 145a Neighboring gene cardiac mesoderm enhancer-associated non-coding RNA Neighboring gene microRNA 143 Neighboring gene predicted gene, 38165 Neighboring gene STARR-positive B cell enhancer mm9_chr18:61857809-61858110 Neighboring gene prenylcysteine oxidase 1 like Neighboring gene STARR-seq mESC enhancer starr_44762 Neighboring gene GrpE-like 2, mitochondrial Neighboring gene predicted gene, 17883

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Interleukin 17 B regulates colonic myeloid cell infiltration in a mouse model of DSS-induced colitis. Zhang X, et al. Front Immunol, 2023. PMID 36814913, Free PMC Article
    2. Necroptosis Plays a Crucial Role in Vascular Injury during DVT and Is Enhanced by IL-17B. Li Y, et al. J Immunol Res, 2022. PMID 36046722, Free PMC Article
    3. Expression of interleukin-17B in mouse embryonic limb buds and regulation by BMP-7 and bFGF. You Z, et al. Biochem Biophys Res Commun, 2005 Jan 21. PMID 15596145
    4. IL-17B alleviates the pathogenesis of systemic lupus erythematosus by inhibiting FASN-mediated differentiation of B cells. Xiao Y, et al. JCI Insight, 2024 Aug 8. PMID 39115936, Free PMC Article
    5. Expression of IL-17B in neurons and evaluation of its possible role in the chromosome 5q-linked form of Charcot-Marie-Tooth disease. Moore EE, et al. Neuromuscul Disord, 2002 Feb. PMID 11738356

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IL-17B alleviates the pathogenesis of systemic lupus erythematosus by inhibiting FASN-mediated differentiation of B cells.
      Title: IL-17B alleviates the pathogenesis of systemic lupus erythematosus by inhibiting FASN-mediated differentiation of B cells.
    2. Necroptosis Plays a Crucial Role in Vascular Injury during DVT and Is Enhanced by IL-17B.
      Title: Necroptosis Plays a Crucial Role in Vascular Injury during DVT and Is Enhanced by IL-17B.
    3. Interleukin-17B antagonizes interleukin-25-mediated mucosal inflammation.
      Title: Interleukin-17B Antagonizes Interleukin-25-Mediated Mucosal Inflammation.
    4. Results show that amplified signaling of interleukin-17 receptor B (IL-17RB) and its ligand IL-17B promot tumorigenicity in breast cancer cells and impeded acinus formation in immortalized normal mammary epithelial cells.
      Title: Autocrine/paracrine mechanism of interleukin-17B receptor promotes breast tumorigenesis through NF-κB-mediated antiapoptotic pathway.
    5. IL-17B and IL-17C play an important role in the pathogenesis of inflammatory arthritis.
      Title: IL-17B and IL-17C are associated with TNF-alpha production and contribute to the exacerbation of inflammatory arthritis.
    6. expressed in the mouse embryonic limb buds and may play a role in chondrogenesis and osteogenesis
      Title: Expression of interleukin-17B in mouse embryonic limb buds and regulation by BMP-7 and bFGF.
    7. Socs3 is an essential negative regulator of IL-23 signaling, inhibition of which constrains the generation of IL-17-secreting T-cell differentiation
      Title: Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neutrophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cytokine production involved in inflammatory response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-17B
    Names
    IL-17B
    cytokine CX1
    cytokine-like protein ZCYTO7
    gene for cytokine-like protein
    neuronal interleukin-17-related factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019508.1 → NP_062381.1  interleukin-17B precursor

      See identical proteins and their annotated locations for NP_062381.1

      Status: PROVISIONAL

      Source sequence(s)
      AF184970
      Consensus CDS
      CCDS29286.1
      UniProtKB/Swiss-Prot
      Q99MY3, Q9CTI4, Q9QXT6
      Related
      ENSMUSP00000025471.3, ENSMUST00000025471.4
      Conserved Domains (1) summary
      pfam06083
      Location:96 → 179
      IL17; Interleukin-17

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      61821006..61825609
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250543.2 → XP_030106403.1  interleukin-17B isoform X2

      Conserved Domains (1) summary
      pfam06083
      Location:41 → 120
      IL17; Interleukin-17

    2. XM_006526106.4 → XP_006526169.1  interleukin-17B isoform X1

      Conserved Domains (1) summary
      pfam06083
      Location:101 → 180
      IL17; Interleukin-17

    3. XM_006526108.5 → XP_006526171.1  interleukin-17B isoform X2

      See identical proteins and their annotated locations for XP_006526171.1

      Conserved Domains (1) summary
      pfam06083
      Location:41 → 120
      IL17; Interleukin-17
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QXT6.1 GenPept UniProtKB/Swiss-Prot:Q9QXT6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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