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    Snrk SNF related kinase [ Mus musculus (house mouse) ]

    Gene ID: 20623, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Snrkprovided by MGI
    Official Full Name
    SNF related kinaseprovided by MGI
    Primary source
    MGI:MGI:108104
    See related
    Ensembl:ENSMUSG00000038145 AllianceGenome:MGI:108104
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0096; E030034B15; 2010012F07Rik
    Summary
    Predicted to enable ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; gut; heart and pericardium; hemolymphoid system; and retina. Orthologous to human SNRK (SNF related kinase). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 60.4), lung adult (RPKM 41.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Snrk in Genome Data Viewer
    Location:
    9 F4; 9 72.89 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (121946332..121998768)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (122117266..122169702)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39463 Neighboring gene predicted gene, 39465 Neighboring gene predicted gene, 39464 Neighboring gene STARR-seq mESC enhancer starr_25542 Neighboring gene STARR-seq mESC enhancer starr_25543 Neighboring gene predicted gene, 57550 Neighboring gene anoctamin 10 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:122142092-122142320 Neighboring gene STARR-seq mESC enhancer starr_25545 Neighboring gene STARR-positive B cell enhancer ABC_E574 Neighboring gene microRNA 8106 Neighboring gene predicted gene, 26797

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DNA Damage and Nuclear Morphological Changes in Cardiac Hypertrophy Are Mediated by SNRK Through Actin Depolymerization. Stanczyk PJ, et al. Circulation, 2023 Nov 14. PMID 37721051,
    2. Cardiomyocyte-Specific Snrk Prevents Inflammation in the Heart. Thirugnanam K, et al. J Am Heart Assoc, 2019 Nov 19. PMID 31718444, Free PMC Article
    3. Dysregulation of PP2A-Akt interaction contributes to Sucrose non-fermenting related kinase (SNRK) deficiency induced insulin resistance in adipose tissue. Li J, et al. Mol Metab, 2019 Oct. PMID 31420304, Free PMC Article
    4. SNRK (Sucrose Nonfermenting 1-Related Kinase) Promotes Angiogenesis In Vivo. Lu Q, et al. Arterioscler Thromb Vasc Biol, 2018 Feb. PMID 29242271, Free PMC Article
    5. Identification of sucrose non-fermenting-related kinase (SNRK) as a suppressor of adipocyte inflammation. Li Y, et al. Diabetes, 2013 Jul. PMID 23520131, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DNA Damage and Nuclear Morphological Changes in Cardiac Hypertrophy Are Mediated by SNRK Through Actin Depolymerization.
      Title: DNA Damage and Nuclear Morphological Changes in Cardiac Hypertrophy Are Mediated by SNRK Through Actin Depolymerization.
    2. Cardiomyocyte-Specific Snrk Prevents Inflammation in the Heart.
      Title: Cardiomyocyte-Specific Snrk Prevents Inflammation in the Heart.
    3. The SNRK regulates insulin signaling through controlling PPP2R5D phosphorylation, which subsequently impacts PP2A activity and then AKT phosphorylation in both WAT and BAT. SNRK may represent a promising potential target for treating insulin resistance-related metabolic disorders.
      Title: Dysregulation of PP2A-Akt interaction contributes to Sucrose non-fermenting related kinase (SNRK) deficiency induced insulin resistance in adipose tissue.
    4. Endothelial cell SNRK/SP1-ITGB1 signaling axis promotes angiogenesis in vivo.
      Title: SNRK (Sucrose Nonfermenting 1-Related Kinase) Promotes Angiogenesis In Vivo.
    5. Using SNRK transgenic and KO mouse models, study found that SNRK decreases cardiac metabolic substrate usage and mitochondrial coupling, while protecting against ischaemia/reperfusion injury. Effects on substrate usage and cell death are dependent on UCP3, which is downregulated through suppression of PPARalpha by Trib3, a novel binding partner of SNRK.
      Title: Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling.
    6. SNRK in cardiomyocytes is responsible for maintaining cardiac metabolic homeostasis, which is mediated in part by ROCK, and alteration of this homeostasis influences cardiac function in the adult heart.
      Title: Sucrose Nonfermenting-Related Kinase Enzyme-Mediated Rho-Associated Kinase Signaling is Responsible for Cardiac Function.
    7. SNRK may act as a suppressor of adipocyte inflammation and its presence is necessary for maintaining normal adipocyte function.
      Title: Identification of sucrose non-fermenting-related kinase (SNRK) as a suppressor of adipocyte inflammation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (6)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC28970

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    SNF-related serine/threonine-protein kinase
    Names
    SNF1-related kinase
    NP_001158044.1
    NP_001344703.1
    NP_001344704.1
    NP_001344705.1
    NP_598502.2
    XP_006512062.1
    XP_006512063.1
    XP_006512065.1
    XP_036010647.1
    XP_036010648.1
    XP_036010649.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164572.1 → NP_001158044.1  SNF-related serine/threonine-protein kinase

      See identical proteins and their annotated locations for NP_001158044.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. All five variants encode the same protein.
      Source sequence(s)
      AC120394, AI842097, BC150742, CJ079755
      Consensus CDS
      CCDS23644.1
      UniProtKB/Swiss-Prot
      Q8VDU5, Q91WX6
      UniProtKB/TrEMBL
      B9EK90
      Related
      ENSMUSP00000112919.2, ENSMUST00000120173.9
      Conserved Domains (2) summary
      cd14339
      Location:288 → 335
      UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
      cd14074
      Location:12 → 269
      STKc_SNRK; Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase

    2. NM_001357774.1 → NP_001344703.1  SNF-related serine/threonine-protein kinase

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. All five variants encode the same protein.
      Source sequence(s)
      AC120394, AK082185
      Consensus CDS
      CCDS23644.1
      UniProtKB/Swiss-Prot
      Q8VDU5, Q91WX6
      UniProtKB/TrEMBL
      B9EK90
      Conserved Domains (2) summary
      cd14339
      Location:288 → 335
      UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
      cd14074
      Location:12 → 269
      STKc_SNRK; Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase

    3. NM_001357775.1 → NP_001344704.1  SNF-related serine/threonine-protein kinase

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. All five variants encode the same protein.
      Source sequence(s)
      AC120394
      Consensus CDS
      CCDS23644.1
      UniProtKB/Swiss-Prot
      Q8VDU5, Q91WX6
      UniProtKB/TrEMBL
      B9EK90
      Conserved Domains (2) summary
      cd14339
      Location:288 → 335
      UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
      cd14074
      Location:12 → 269
      STKc_SNRK; Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase

    4. NM_001357776.1 → NP_001344705.1  SNF-related serine/threonine-protein kinase

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 3. All five variants encode the same protein.
      Source sequence(s)
      AC120394
      Consensus CDS
      CCDS23644.1
      UniProtKB/Swiss-Prot
      Q8VDU5, Q91WX6
      UniProtKB/TrEMBL
      B9EK90
      Conserved Domains (2) summary
      cd14339
      Location:288 → 335
      UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
      cd14074
      Location:12 → 269
      STKc_SNRK; Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase

    5. NM_133741.2 → NP_598502.2  SNF-related serine/threonine-protein kinase

      See identical proteins and their annotated locations for NP_598502.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. All five variants encode the same protein.
      Source sequence(s)
      AC120394, AI842097, BC150742, CJ079755
      Consensus CDS
      CCDS23644.1
      UniProtKB/Swiss-Prot
      Q8VDU5, Q91WX6
      UniProtKB/TrEMBL
      B9EK90
      Related
      ENSMUSP00000114132.2, ENSMUST00000118886.9
      Conserved Domains (2) summary
      cd14339
      Location:288 → 335
      UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
      cd14074
      Location:12 → 269
      STKc_SNRK; Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      121946332..121998768
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512000.5 → XP_006512063.1  SNF-related serine/threonine-protein kinase isoform X1

      See identical proteins and their annotated locations for XP_006512063.1

      UniProtKB/Swiss-Prot
      Q8VDU5, Q91WX6
      UniProtKB/TrEMBL
      B9EK90
      Conserved Domains (2) summary
      cd14339
      Location:288 → 335
      UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
      cd14074
      Location:12 → 269
      STKc_SNRK; Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase

    2. XM_006512002.4 → XP_006512065.1  SNF-related serine/threonine-protein kinase isoform X1

      See identical proteins and their annotated locations for XP_006512065.1

      UniProtKB/Swiss-Prot
      Q8VDU5, Q91WX6
      UniProtKB/TrEMBL
      B9EK90
      Conserved Domains (2) summary
      cd14339
      Location:288 → 335
      UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
      cd14074
      Location:12 → 269
      STKc_SNRK; Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase

    3. XM_006511999.5 → XP_006512062.1  SNF-related serine/threonine-protein kinase isoform X1

      See identical proteins and their annotated locations for XP_006512062.1

      UniProtKB/Swiss-Prot
      Q8VDU5, Q91WX6
      UniProtKB/TrEMBL
      B9EK90
      Conserved Domains (2) summary
      cd14339
      Location:288 → 335
      UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
      cd14074
      Location:12 → 269
      STKc_SNRK; Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase

    4. XM_036154754.1 → XP_036010647.1  SNF-related serine/threonine-protein kinase isoform X1

      UniProtKB/Swiss-Prot
      Q8VDU5, Q91WX6
      UniProtKB/TrEMBL
      B9EK90
      Conserved Domains (2) summary
      cd14339
      Location:288 → 335
      UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
      cd14074
      Location:12 → 269
      STKc_SNRK; Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase

    5. XM_036154755.1 → XP_036010648.1  SNF-related serine/threonine-protein kinase isoform X1

      UniProtKB/Swiss-Prot
      Q8VDU5, Q91WX6
      UniProtKB/TrEMBL
      B9EK90
      Conserved Domains (2) summary
      cd14339
      Location:288 → 335
      UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
      cd14074
      Location:12 → 269
      STKc_SNRK; Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase

    6. XM_036154756.1 → XP_036010649.1  SNF-related serine/threonine-protein kinase isoform X1

      UniProtKB/Swiss-Prot
      Q8VDU5, Q91WX6
      UniProtKB/TrEMBL
      B9EK90
      Conserved Domains (2) summary
      cd14339
      Location:288 → 335
      UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
      cd14074
      Location:12 → 269
      STKc_SNRK; Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VDU5.1 GenPept UniProtKB/Swiss-Prot:Q8VDU5

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