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    Rab22a RAB22A, member RAS oncogene family [ Mus musculus (house mouse) ]

    Gene ID: 19334, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Rab22aprovided by MGI
    Official Full Name
    RAB22A, member RAS oncogene familyprovided by MGI
    Primary source
    MGI:MGI:105072
    See related
    Ensembl:ENSMUSG00000027519 AllianceGenome:MGI:105072
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rab22; 3732413A17Rik; E130120E14Rik
    Summary
    Enables GTP binding activity and GTPase activity. Predicted to be involved in endocytosis; intracellular protein transport; and regulation of vesicle size. Located in actin cytoskeleton. Orthologous to human RAB22A (RAB22A, member RAS oncogene family). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 24.0), testis adult (RPKM 24.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rab22a in Genome Data Viewer
    Location:
    2 H4; 2 97.26 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (173501638..173543975)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (173659836..173702186)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 60 Neighboring gene protein phosphatase 4, regulatory subunit 1-like, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8799 Neighboring gene STARR-positive B cell enhancer ABC_E7891 Neighboring gene STARR-positive B cell enhancer ABC_E648 Neighboring gene microRNA 6340 Neighboring gene RIKEN cDNA 1700010B08 gene Neighboring gene STARR-positive B cell enhancer ABC_E1610 Neighboring gene vesicle-associated membrane protein, associated protein B and C Neighboring gene adenomatosis polyposis coli down-regulated 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Rab22a controls MHC-I intracellular trafficking and antigen cross-presentation by dendritic cells. Cebrian I, et al. EMBO Rep, 2016 Dec. PMID 27861124, Free PMC Article
    2. Intercellular transfer of activated STING triggered by RAB22A-mediated non-canonical autophagy promotes antitumor immunity. Gao Y, et al. Cell Res, 2022 Dec. PMID 36280710, Free PMC Article
    3. Rab22A recruits BLOC-1 and BLOC-2 to promote the biogenesis of recycling endosomes. Shakya S, et al. EMBO Rep, 2018 Dec. PMID 30404817, Free PMC Article
    4. Molecular cloning and subcellular localization of three GTP-binding proteins of the rab subfamily. Olkkonen VM, et al. J Cell Sci, 1993 Dec. PMID 8126105
    5. Rin-like, a novel regulator of endocytosis, acts as guanine nucleotide exchange factor for Rab5a and Rab22. Woller B, et al. Biochim Biophys Acta, 2011 Jun. PMID 21419809, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Intercellular transfer of activated STING triggered by RAB22A-mediated non-canonical autophagy promotes antitumor immunity.
      Title: Intercellular transfer of activated STING triggered by RAB22A-mediated non-canonical autophagy promotes antitumor immunity.
    2. Rab22A promotes the assembly of a BLOC-1-BLOC-2-KIF13A complex on early/sorting endosomes.
      Title: Rab22A recruits BLOC-1 and BLOC-2 to promote the biogenesis of recycling endosomes.
    3. findings provide compelling evidence that Rab22a plays a central role in the MHC-I endocytic trafficking, which is crucial for efficient cross-presentation by dendritic cells
      Title: Rab22a controls MHC-I intracellular trafficking and antigen cross-presentation by dendritic cells.
    4. Data show that Rinl is closely associated with the cytoskeleton and thus contributes to the spatial control of Rab5a and Rab22 signaling at actin-positive compartments.
      Title: Rin-like, a novel regulator of endocytosis, acts as guanine nucleotide exchange factor for Rab5a and Rab22.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GDP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosome organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of vesicle size IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of vesicle size ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in late endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in phagocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in phagocytic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in phagocytic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ruffle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ras-related protein Rab-22A
    Names
    RAB22, member RAS oncogene family
    rab-14
    rab-22
    NP_077756.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024436.3 → NP_077756.2  ras-related protein Rab-22A

      See identical proteins and their annotated locations for NP_077756.2

      Status: PROVISIONAL

      Source sequence(s)
      AK146594
      Consensus CDS
      CCDS38352.1
      UniProtKB/Swiss-Prot
      P35285, Q3UCA7, Q91VD4
      UniProtKB/TrEMBL
      Q0PD34, Q9CXG2
      Related
      ENSMUSP00000029024.4, ENSMUST00000029024.10
      Conserved Domains (1) summary
      cd01860
      Location:5 → 167
      Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      173501638..173543975
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35285.2 GenPept UniProtKB/Swiss-Prot:P35285

    Gene LinkOut

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