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    Rnf103 ring finger protein 103 [ Mus musculus (house mouse) ]

    Gene ID: 22644, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Rnf103provided by MGI
    Official Full Name
    ring finger protein 103provided by MGI
    Primary source
    MGI:MGI:109483
    See related
    Ensembl:ENSMUSG00000052656 AllianceGenome:MGI:109483
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    kf-1; Zfp103
    Summary
    This gene encodes a member of the RING finger family of E3 ubiquitin-protein ligases. These proteins catalyze the transfer of the ubiquitin protein from a ubiquitin E2 enzyme to a protein substrate. Homozygous knockout mice for this gene exhibit enhanced anxiety-like behavior. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
    Expression
    Ubiquitous expression in colon adult (RPKM 26.1), duodenum adult (RPKM 20.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rnf103 in Genome Data Viewer
    Location:
    6 C1; 6 32.16 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (71470828..71487864)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (71493844..71510880)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16262 Neighboring gene required for meiotic nuclear division 5 homolog A Neighboring gene STARR-positive B cell enhancer ABC_E343 Neighboring gene predicted gene, 30582 Neighboring gene STARR-positive B cell enhancer ABC_E10384 Neighboring gene STARR-positive B cell enhancer ABC_E8110 Neighboring gene charged multivesicular body protein 3 Neighboring gene STARR-seq mESC enhancer starr_16264 Neighboring gene lysine (K)-specific demethylase 3A Neighboring gene STARR-seq mESC enhancer starr_16265 Neighboring gene STARR-positive B cell enhancer ABC_E3659

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. KF-1 ubiquitin ligase: anxiety suppressor model. Hashimoto-Gotoh T, et al. Cell Biochem Biophys, 2011 Jun. PMID 21455683
    2. KF-1 Ubiquitin Ligase: An Anxiety Suppressor. Hashimoto-Gotoh T, et al. Front Neurosci, 2009 May. PMID 19753093, Free PMC Article
    3. Mice lacking the kf-1 gene exhibit increased anxiety- but not despair-like behavior. Tsujimura A, et al. Front Behav Neurosci, 2008. PMID 18958194, Free PMC Article
    4. Cloning of human and mouse cDNAs encoding novel zinc finger proteins expressed in cerebellum and hippocampus. Yasojima K, et al. Biochem Biophys Res Commun, 1997 Feb 13. PMID 9070305
    5. Identification of a novel gene with RING-H2 finger motif induced after chronic antidepressant treatment in rat brain. Yamada M, et al. Biochem Biophys Res Commun, 2000 Nov 11. PMID 11071867

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ERAD pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF103
    Names
    RING-type E3 ubiquitin transferase RNF103
    zinc finger protein 103
    NP_001295232.1
    NP_001397436.1
    NP_001397437.1
    NP_033569.2
    XP_036021921.1
    XP_036021922.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308303.2 → NP_001295232.1  E3 ubiquitin-protein ligase RNF103 isoform 2

      See identical proteins and their annotated locations for NP_001295232.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in its 3' terminal exon, resulting in a distinct 5' UTR and the use of a downstream in-frame start site, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2-4 all encode the same isoform (2).
      Source sequence(s)
      AC154001
      UniProtKB/TrEMBL
      Q3TGP6
      Conserved Domains (1) summary
      cd16473
      Location:444 → 489
      RING-H2_RNF103; RING finger, H2 subclass, found in RING finger protein 103 (RNF103) and similar proteins

    2. NM_001410507.1 → NP_001397436.1  E3 ubiquitin-protein ligase RNF103 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC154001
      UniProtKB/TrEMBL
      Q3TGP6

    3. NM_001410508.1 → NP_001397437.1  E3 ubiquitin-protein ligase RNF103 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC154001
      UniProtKB/TrEMBL
      Q3TGP6

    4. NM_009543.4 → NP_033569.2  E3 ubiquitin-protein ligase RNF103 isoform 1

      See identical proteins and their annotated locations for NP_033569.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC154001
      Consensus CDS
      CCDS39508.1
      UniProtKB/Swiss-Prot
      B9EHC2, O08670, O08883, Q9R1W3
      Related
      ENSMUSP00000066324.5, ENSMUST00000064637.11
      Conserved Domains (1) summary
      cd00162
      Location:618 → 661
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      71470828..71487864
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036166029.1 → XP_036021922.1  E3 ubiquitin-protein ligase RNF103 isoform X2

      UniProtKB/TrEMBL
      D3Z0Y5, Q3UYK9
      Related
      ENSMUSP00000109816.2, ENSMUST00000114178.8

    2. XM_036166028.1 → XP_036021921.1  E3 ubiquitin-protein ligase RNF103 isoform X1

      UniProtKB/TrEMBL
      Q3UYK9
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R1W3.2 GenPept UniProtKB/Swiss-Prot:Q9R1W3

    Gene LinkOut

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