Cxcr1 C-X-C motif chemokine receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cxcr1provided by MGI
Official Full Name: C-X-C motif chemokine receptor 1provided by MGI
Primary source: MGI:MGI:2448715
See related: Ensembl:ENSMUSG00000048480 AllianceGenome:MGI:2448715
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Il8ra
Summary: Predicted to enable chemokine binding activity and chemokine receptor activity. Predicted to be involved in several processes, including neutrophil chemotaxis; positive regulation of cytosolic calcium ion concentration; and receptor internalization. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane. Is expressed in bone marrow and lung. Human ortholog(s) of this gene implicated in human immunodeficiency virus infectious disease; pyelonephritis; and urinary tract infection. Orthologous to human CXCR1 (C-X-C motif chemokine receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 1 C3; 1 38.44 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (74228862..74233867, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (74191785..74194708, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CXCR1 drives the pathogenesis of EAE and ARDS via boosting dendritic cells-dependent inflammation.
Title: CXCR1 drives the pathogenesis of EAE and ARDS via boosting dendritic cells-dependent inflammation.
IL-10 in combination with IL-12 and TNF-alpha attenuates CXCL8/CXCR1 axis in peritoneal macrophages of mice infected with Staphylococcus aureus through the TNFR1-IL-1R-NF-kappaB pathway.
Title: IL-10 in combination with IL-12 and TNF-α attenuates CXCL8/CXCR1 axis in peritoneal macrophages of mice infected with Staphylococcus aureus through the TNFR1-IL-1R-NF-κB pathway.
CXCR1 and its downstream NF-kappaB inflammation signaling pathway as a key target of Guanxinning injection for myocardial ischemia/reperfusion injury.
Title: CXCR1 and its downstream NF-κB inflammation signaling pathway as a key target of Guanxinning injection for myocardial ischemia/reperfusion injury.
MiR-144-induced KLF2 inhibition and NF-kappaB/CXCR1 activation promote neutrophil extracellular trap-induced transfusion-related acute lung injury.
Title: MiR-144-induced KLF2 inhibition and NF-kappaB/CXCR1 activation promote neutrophil extracellular trap-induced transfusion-related acute lung injury.
CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity.
Title: CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity.
Attenuation of murine allergic airway inflammation with a CXCR1/CXCR2 chemokine receptor inhibitor.
Title: Attenuation of murine allergic airway inflammation with a CXCR1/CXCR2 chemokine receptor inhibitor.
mRNA and protein expression of CXCR1 was higher in the liver and sWAT tissue of db/db mice than db/m mice.
Title: The antagonist of CXCR1 and CXCR2 protects db/db mice from metabolic diseases through modulating inflammation.
these studies define CXCR1 as a novel, noncanonical chemokine receptor that regulates pulmonary anti-Pseudomonas host defense with broad implications for cystic fibrosis, chronic obstructive pulmonary disease and other infectious lung diseases
Title: CXCR1 Regulates Pulmonary Anti-Pseudomonas Host Defense.
CXCR1 and CXCR2 regulate hepatocyte exosome release. The mechanism utilized by CXCR1 remains elusive, but CXCR2 appears to modulate Nsm activity and resultant production of ceramide to control exosome release. CXCR1 is required for packaging of enzymes into exosomes that mediate their hepatocyte proliferative effect.
Title: Chemokine Receptors, CXCR1 and CXCR2, Differentially Regulate Exosome Release in Hepatocytes.
These data demonstrate a biological function for mouse Cxcr1 in vivo and indicate that CXCR1-dependent neutrophil effector function is a critical innate protective mechanism of fungal clearance and host survival in systemic candidiasis.
Title: CXCR1-mediated neutrophil degranulation and fungal killing promote Candida clearance and host survival.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:490708

NoName (e-PCR)
- UniSTS:494053

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables C-C chemokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables C-C chemokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables C-X-C chemokine receptor activity	IEA Inferred from Electronic Annotation more info
enables interleukin-8 binding	ISO Inferred from Sequence Orthology more info
enables interleukin-8 receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in calcium-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in chemokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in neutrophil chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor internalization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: C-X-C chemokine receptor type 1

Names: CXC chemokine receptor 1; chemokine (C-X-C motif) receptor 1; high affinity interleukin-8 receptor A; interleukin 8 receptor, alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178241.5 → NP_839972.1 C-X-C chemokine receptor type 1

See identical proteins and their annotated locations for NP_839972.1

Status: VALIDATED

Source sequence(s)

AC113473

Consensus CDS

CCDS15041.1

UniProtKB/Swiss-Prot

Q810W6

Related

ENSMUSP00000049714.5, ENSMUST00000053389.5

Conserved Domains (1) summary

cd15178
Location:45 → 321

7tmA_CXCR1_2; CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

74228862..74233867 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006495956.1 → XP_006496019.1 C-X-C chemokine receptor type 1 isoform X2

Conserved Domains (2) summary

cd14964
Location:2 → 26

7tm_GPCRs; TM helix 2 [structural motif]

cl28897
Location:2 → 243

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_030253700.2 → XP_030109560.1 C-X-C chemokine receptor type 1 isoform X1

UniProtKB/Swiss-Prot

Q810W6

Related

ENSMUSP00000139555.2, ENSMUST00000190313.2

Conserved Domains (1) summary

cd15178
Location:45 → 321

7tmA_CXCR1_2; CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors