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    Vmn2r120 vomeronasal 2, receptor 120 [ Mus musculus (house mouse) ]

    Gene ID: 224916, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Vmn2r120provided by MGI
    Official Full Name
    vomeronasal 2, receptor 120provided by MGI
    Primary source
    MGI:MGI:3644483
    See related
    Ensembl:ENSMUSG00000090655 AllianceGenome:MGI:3644483
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EG224916
    Summary
    Enables G protein-coupled olfactory receptor activity. Acts upstream of or within neuron differentiation. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See Vmn2r120 in Genome Data Viewer
    Location:
    17 D; 17 29.88 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (57815783..57852314, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (57508783..57545314, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene adhesion G protein-coupled receptor E1 Neighboring gene heat shock protein 8 pseudogene Neighboring gene U1 small nuclear ribonucleoprotein C pseudogene Neighboring gene STARR-seq mESC enhancer starr_42922 Neighboring gene STARR-seq mESC enhancer starr_42923 Neighboring gene STARR-seq mESC enhancer starr_42924 Neighboring gene STARR-seq mESC enhancer starr_42925 Neighboring gene predicted gene, 54014 Neighboring gene predicted gene, 18139

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Subpopulations of vomeronasal sensory neurons with coordinated coexpression of type 2 vomeronasal receptor genes are differentially dependent on Vmn2r1. Akiyoshi S, et al. Eur J Neurosci, 2018 Apr. PMID 29465786, Free PMC Article
    2. V2R gene families degenerated in primates, dog and cow, but expanded in opossum. Young JM, et al. Trends Genet, 2007 May. PMID 17382427
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled olfactory receptor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within detection of chemical stimulus involved in sensory perception of smell IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    vomeronasal receptor Vmn2r120

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001385181.1 → NP_001372110.1  vomeronasal receptor Vmn2r120 precursor

      Status: VALIDATED

      Source sequence(s)
      CT010434, CT010448
      Consensus CDS
      CCDS50161.1
      UniProtKB/TrEMBL
      A0A8V5KX69, E9PX34
      Related
      ENSMUSP00000159505.1, ENSMUST00000240712.1
      Conserved Domains (3) summary
      cd15283
      Location:584 → 832
      7tmC_V2R_pheromone; vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G protein-coupled receptors
      cd06365
      Location:40 → 503
      PBP1_pheromone_receptor; Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily
      pfam07562
      Location:511 → 564
      NCD3G; Nine Cysteines Domain of family 3 GPCR

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      57815783..57852314 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001104591.1: Suppressed sequence

      Description
      NM_001104591.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein
    Heading Accession and Version

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