U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Taco1 translational activator of mitochondrially encoded cytochrome c oxidase I [ Mus musculus (house mouse) ]

    Gene ID: 70207, updated on 17-Aug-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Taco1provided by MGI
    Official Full Name
    translational activator of mitochondrially encoded cytochrome c oxidase Iprovided by MGI
    Primary source
    MGI:MGI:1917457
    See related
    Ensembl:ENSMUSG00000001983 AllianceGenome:MGI:1917457
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ccdc44; 2310066I18Rik
    Summary
    Enables mRNA binding activity; mitochondrial ribosome binding activity; and rRNA binding activity. Acts upstream of or within several processes, including mitochondrial cytochrome c oxidase assembly; motor learning; and regulation of cytochrome-c oxidase activity. Located in mitochondrion. Is expressed in several structures, including alimentary system; nervous system; nose; orbito-sphenoid; and pharyngo-tympanic tube. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease. Orthologous to human TACO1 (translational activator of cytochrome c oxidase I). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in heart adult (RPKM 10.7), kidney adult (RPKM 7.0) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Taco1 in Genome Data Viewer
    Location:
    11 E1; 11 68.89 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (105956885..105964861)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (106066057..106074035)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35971 Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 6 Neighboring gene STARR-positive B cell enhancer ABC_E43 Neighboring gene DDB1 and CUL4 associated factor 7 Neighboring gene translational activator of mitochondrially encoded cytochrome c oxidase I, opposite strand Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:105927234-105927440 Neighboring gene STARR-seq mESC enhancer starr_30915 Neighboring gene STARR-positive B cell enhancer ABC_E2372 Neighboring gene STARR-positive B cell enhancer ABC_E258 Neighboring gene mitogen-activated protein kinase kinase kinase 3 Neighboring gene STARR-seq mESC enhancer starr_30916 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:106020710-106020950 Neighboring gene predicted gene 10840 Neighboring gene LIM domain containing 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Murine cytomegalovirus infection exacerbates complex IV deficiency in a model of mitochondrial disease. Ferreira N, et al. PLoS Genet, 2020 Mar. PMID 32130224, Free PMC Article
    2. Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice. Richman TR, et al. Nat Commun, 2016 Jun 20. PMID 27319982, Free PMC Article
    3. Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios. Clark AG, et al. Science, 2003 Dec 12. PMID 14671302
    4. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    5. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mitochondrial ribosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables rRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within mitochondrial cytochrome c oxidase assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within motor learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cytochrome-c oxidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of mitochondrial translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    translational activator of cytochrome c oxidase 1
    Names
    coiled-coil domain-containing protein 44
    translational activator of mitochondrially-encoded cytochrome c oxidase 1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027346.2 → NP_081622.1  translational activator of cytochrome c oxidase 1

      See identical proteins and their annotated locations for NP_081622.1

      Status: VALIDATED

      Source sequence(s)
      AK047078, AW491435
      Consensus CDS
      CCDS25547.1
      UniProtKB/Swiss-Prot
      B1AR86, Q3TI86, Q3USS8, Q8K0Z7, Q9CV09
      Related
      ENSMUSP00000002048.8, ENSMUST00000002048.8
      Conserved Domains (1) summary
      pfam01709
      Location:58 → 293
      Transcrip_reg; Transcriptional regulator

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      105956885..105964861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156974.1 → XP_036012867.1  translational activator of cytochrome c oxidase 1 isoform X1

      Conserved Domains (1) summary
      pfam01709
      Location:58 → 169
      Transcrip_reg; Transcriptional regulator
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K0Z7.1 GenPept UniProtKB/Swiss-Prot:Q8K0Z7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools