U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Syncrip synaptotagmin binding, cytoplasmic RNA interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 56403, updated on 28-Oct-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Syncripprovided by MGI
    Official Full Name
    synaptotagmin binding, cytoplasmic RNA interacting proteinprovided by MGI
    Primary source
    MGI:MGI:1891690
    See related
    Ensembl:ENSMUSG00000032423 AllianceGenome:MGI:1891690
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    pp68; Nsap1; Nsap1l; GRY-RBP; hnRNP Q; 2610109K23Rik; 4632417O19Rik
    Summary
    Enables poly(A) binding activity. Predicted to be involved in several processes, including cellular response to type II interferon; negative regulation of mRNA metabolic process; and regulation of translation. Located in cytoplasm. Part of histone pre-mRNA 3'end processing complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human SYNCRIP (synaptotagmin binding cytoplasmic RNA interacting protein). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 10.8), limb E14.5 (RPKM 9.0) and 21 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Syncrip in Genome Data Viewer
    Location:
    9 E3.1; 9 47.24 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (88331417..88364645, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (88449364..88482591, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24855 Neighboring gene 5' nucleotidase, ecto Neighboring gene sorting nexin 14 Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10573 Neighboring gene STARR-seq mESC enhancer starr_24856 Neighboring gene STARR-positive B cell enhancer ABC_E9772 Neighboring gene small nucleolar RNA, C/D box 50A Neighboring gene small nucleolar RNA, C/D box 50B Neighboring gene small nucleolar RNA host gene 5

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The RNA-Binding Protein SYNCRIP Is a Component of the Hepatocyte Exosomal Machinery Controlling MicroRNA Sorting. Santangelo L, et al. Cell Rep, 2016 Oct 11. PMID 27732855
    2. hnRNP Q regulates translation of p53 in normal and stress conditions. Kim DY, et al. Cell Death Differ, 2013 Feb. PMID 22935615, Free PMC Article
    3. hnRNP Q Regulates Internal Ribosome Entry Site-Mediated fmr1 Translation in Neurons. Choi JH, et al. Mol Cell Biol, 2019 Feb 15. PMID 30478144, Free PMC Article
    4. SYNCRIP Modulates the Epithelial-Mesenchymal Transition in Hepatocytes and HCC Cells. Riccioni V, et al. Int J Mol Sci, 2022 Jan 14. PMID 35055098, Free PMC Article
    5. RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells. Herrejon Chavez F, et al. Nat Commun, 2023 Apr 21. PMID 37085479, Free PMC Article

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells.
      Title: RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells.
    2. SYNCRIP Modulates the Epithelial-Mesenchymal Transition in Hepatocytes and HCC Cells.
      Title: SYNCRIP Modulates the Epithelial-Mesenchymal Transition in Hepatocytes and HCC Cells.
    3. hnRNP Q and hnRNP A1 Regulate the Translation of Cofilin in Response to Transient Oxygen-Glucose Deprivation in Hippocampal Neurons.
      Title: hnRNP Q and hnRNP A1 Regulate the Translation of Cofilin in Response to Transient Oxygen-Glucose Deprivation in Hippocampal Neurons.
    4. these results provide new insights into how neuronal HNRNP Q decreases VRK2 mRNA stability and contributes to the prevention of Huntington's disease
      Title: HNRNP Q suppresses polyglutamine huntingtin aggregation by post-transcriptional regulation of vaccinia-related kinase 2.
    5. results suggest that hnRNP Q plays a pivotal role in both Bmal1 translation and BMAL1-regulated gene expression.
      Title: The RNA-binding protein hnRNP Q represses translation of the clock gene Bmal1 in murine cells.
    6. Semaphorin 3A (Sema3A)-induced axonal growth cone collapse is due to upregulation of hnRNP Q and subsequent IRES-mediated expression of FMRP.
      Title: hnRNP Q Regulates Internal Ribosome Entry Site-Mediated fmr1 Translation in Neurons.
    7. SYNCRIP (synaptotagmin-binding cytoplasmic RNA-interacting protein; also known as hnRNP-Q or NSAP1) is a component of the hepatocyte exosomal miRNA sorting machinery.
      Title: The RNA-Binding Protein SYNCRIP Is a Component of the Hepatocyte Exosomal Machinery Controlling MicroRNA Sorting.
    8. SYNCRIP is required to maintain myeloid leukemia survival.
      Title: Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells.
    9. hnRNP Q binds to mCry1 mRNA via the 5'UTR. Furthermore, hnRNP Q inhibits the translation of mCry1 mRNA, leading to altered rhythmicity in the mCRY1 protein profile.
      Title: HnRNP Q Has a Suppressive Role in the Translation of Mouse Cryptochrome1.
    10. hnRNP-Q1-mediated repression of Gap-43 mRNA translation provides an additional mechanism for regulating GAP-43 expression and function and may be critical for neuronal development.
      Title: hnRNP-Q1 represses nascent axon growth in cortical neurons by inhibiting Gap-43 mRNA translation.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3) 

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA 5'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA 5'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables poly(A) binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CRD-mediated mRNA stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in CRD-mediated mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to type II interferon ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of mRNA modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytoplasmic translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of CRD-mediated mRNA stability complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CRD-mediated mRNA stability complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of CRD-mediated mRNA stability complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of GAIT complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of histone pre-mRNA 3'end processing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mCRD-mediated mRNA stability complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mRNA editing complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in proximal dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    heterogeneous nuclear ribonucleoprotein Q
    Names
    NS1-associated protein 1
    RRM RNA binding protein GRY-RBP
    glycine- and tyrosine-rich RNA-binding protein
    hnRNP-Q

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001284328.1 → NP_001271257.1  heterogeneous nuclear ribonucleoprotein Q isoform 3

      See identical proteins and their annotated locations for NP_001271257.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses a distinct 3' terminal exon and differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting protein (isoform 3) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      BC080309, CT025673
      Consensus CDS
      CCDS72292.1
      UniProtKB/TrEMBL
      A0A0R4J259, G3UZI2
      Related
      ENSMUSP00000134071.2, ENSMUST00000174282.8
      Conserved Domains (2) summary
      TIGR01648
      Location:103 → 553
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      cd21066
      Location:23 → 107
      NURR_hnRNPQ; NURR (N-terminal unit for RNA recognition) domain found in heterogeneous nuclear ribonucleoprotein Q (hnRNPQ) and similar proteins

    2. NM_001311113.1 → NP_001298042.1  heterogeneous nuclear ribonucleoprotein Q isoform 4

      See identical proteins and their annotated locations for NP_001298042.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' and 3' UTRs and has multiple coding region differences compared to variant 1. The resulting isoform (4) has a shorter N-terminus, a distinct C-terminus, and is shorter than isoform 1.
      Source sequence(s)
      AK034845, AK078158, AK083398, BC050079, BY234240, CT025673
      Consensus CDS
      CCDS81048.1
      UniProtKB/TrEMBL
      G3UZ48, G3UZI2
      Related
      ENSMUSP00000134342.2, ENSMUST00000174391.8
      Conserved Domains (1) summary
      TIGR01648
      Location:5 → 459
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

    3. NM_019666.2 → NP_062640.2  heterogeneous nuclear ribonucleoprotein Q isoform 1

      See identical proteins and their annotated locations for NP_062640.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
      Source sequence(s)
      AK162448, BQ559204, BU505018, CN529994, CV562339
      Consensus CDS
      CCDS57686.1
      UniProtKB/Swiss-Prot
      O88991, Q2YDV8, Q68ED6, Q7TMK9, Q80YV6, Q8BGP1, Q8C5K6, Q8CGC2, Q91ZR0, Q99KU9, Q9QYF4
      UniProtKB/TrEMBL
      G3V018
      Related
      ENSMUSP00000133649.2, ENSMUST00000173801.8
      Conserved Domains (2) summary
      TIGR01648
      Location:103 → 615
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      pfam18360
      Location:34 → 103
      hnRNP_Q_AcD; Heterogeneous nuclear ribonucleoprotein Q acidic domain

    4. NM_019796.5 → NP_062770.1  heterogeneous nuclear ribonucleoprotein Q isoform 2

      See identical proteins and their annotated locations for NP_062770.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a distinct 3' terminal exon and differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK034845, CT025673
      Consensus CDS
      CCDS23388.1
      UniProtKB/TrEMBL
      G3UZI2
      Related
      ENSMUSP00000063744.6, ENSMUST00000069221.12
      Conserved Domains (2) summary
      TIGR01648
      Location:103 → 557
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      cd21066
      Location:23 → 107
      NURR_hnRNPQ; NURR (N-terminal unit for RNA recognition) domain found in heterogeneous nuclear ribonucleoprotein Q (hnRNPQ) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      88331417..88364645 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511293.5 → XP_006511356.1  heterogeneous nuclear ribonucleoprotein Q isoform X1

      UniProtKB/TrEMBL
      G3V018
      Conserved Domains (2) summary
      TIGR01648
      Location:103 → 592
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      pfam18360
      Location:34 → 103
      hnRNP_Q_AcD; Heterogeneous nuclear ribonucleoprotein Q acidic domain

    2. XM_006511294.3 → XP_006511357.1  heterogeneous nuclear ribonucleoprotein Q isoform X2

      UniProtKB/TrEMBL
      G3V018
      Conserved Domains (1) summary
      TIGR01648
      Location:5 → 517
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TMK9.2 GenPept UniProtKB/Swiss-Prot:Q7TMK9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools