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    Ankrd6 ankyrin repeat domain 6 [ Mus musculus (house mouse) ]

    Gene ID: 140577, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Ankrd6provided by MGI
    Official Full Name
    ankyrin repeat domain 6provided by MGI
    Primary source
    MGI:MGI:2154278
    See related
    Ensembl:ENSMUSG00000040183 AllianceGenome:MGI:2154278
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    This gene encodes a protein which is thought to be involved in the Wnt signaling pathway and embryonic axis formation. Similar genes have been found in human, rhesus macaque, and zebrafish. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in frontal lobe adult (RPKM 5.9), CNS E14 (RPKM 4.0) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ankrd6 in Genome Data Viewer
    Location:
    4 A5; 4 14.42 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (32804027..32950884, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (32804027..32950885, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42267 Neighboring gene LYR motif containing 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:32951659-32951860 Neighboring gene STARR-seq mESC enhancer starr_09871 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:32993701-32993916 Neighboring gene enoyl-CoA hydratase domain-containing protein 2, mitochondrial pseudogene Neighboring gene STARR-seq mESC enhancer starr_09876 Neighboring gene STARR-seq mESC enhancer starr_09877 Neighboring gene ribosomal protein, large, P1 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:33069120-33069321 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:33069732-33069841 Neighboring gene STARR-seq mESC enhancer starr_09878 Neighboring gene STARR-seq mESC enhancer starr_09880 Neighboring gene Ras-related GTP binding D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Centrosomal localization of Diversin and its relevance to Wnt signaling. Itoh K, et al. J Cell Sci, 2009 Oct 15. PMID 19789178, Free PMC Article
    2. Expression and proliferation-promoting role of Diversin in the neuronally committed precursor cells migrating in the adult mouse brain. Ikeda M, et al. Stem Cells, 2010 Nov. PMID 20827749
    3. Expression of the ankyrin repeat domain 6 gene (Ankrd6) during mouse brain development. Tissir F, et al. Dev Dyn, 2002 Aug. PMID 12203740
    4. The planar cell polarity (PCP) protein Diversin translocates to the nucleus to interact with the transcription factor AF9. Haribaskar R, et al. Biochem Biophys Res Commun, 2009 Sep 11. PMID 19591803
    5. New aspects of Wnt signaling pathways in higher vertebrates. Huelsken J, et al. Curr Opin Genet Dev, 2001 Oct. PMID 11532397

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results indicated that mAnkrd6 is a functional homolog of the Drosophila diego gene for mammalian planar cell polarity (PCP) regulation.
      Title: Ankrd6 is a mammalian functional homolog of Drosophila planar cell polarity gene diego and regulates coordinated cellular orientation in the mouse inner ear.
    2. Results indicate that Diversin plays an important role in the proliferation of neuroblasts in the subventricular zone of the adult brain.
      Title: Expression and proliferation-promoting role of Diversin in the neuronally committed precursor cells migrating in the adult mouse brain.
    3. These observations suggest that the centrosomal localization of Diversin is crucial for its function in Wnt signaling.
      Title: Centrosomal localization of Diversin and its relevance to Wnt signaling.
    4. These data suggest that ankyrin repeat domain 6 (Ankrd6) may be involved in brain development in interaction not only with Celsr/Flamingo but also with other signaling pathways.
      Title: Expression of the ankyrin repeat domain 6 gene (Ankrd6) during mouse brain development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of Wnt signaling pathway, planar cell polarity pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ankyrin repeat domain-containing protein 6
    Names
    diversin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012450.1 → NP_001012453.1  ankyrin repeat domain-containing protein 6

      See identical proteins and their annotated locations for NP_001012453.1

      Status: REVIEWED

      Description
      Transcript Variant: This transcript represents variant 1. Variants 1-4 all encode the same protein.
      Source sequence(s)
      AV290829, BC065177, CF531081
      Consensus CDS
      CCDS18018.1
      UniProtKB/Swiss-Prot
      A2ANZ0, Q69ZU8, Q6P1A8, Q8VHD9
      UniProtKB/TrEMBL
      A2ANY8
      Related
      ENSMUSP00000041300.5, ENSMUST00000035719.11
      Conserved Domains (3) summary
      PHA03095
      Location:29 → 265
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:41 → 72
      ANK; ANK repeat [structural motif]
      pfam11179
      Location:520 → 643
      DUF2967; Protein of unknown function (DUF2967)

    2. NM_001012451.1 → NP_001012454.1  ankyrin repeat domain-containing protein 6

      See identical proteins and their annotated locations for NP_001012454.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
      Source sequence(s)
      AV290829, BC065177, CF533090
      Consensus CDS
      CCDS18018.1
      UniProtKB/Swiss-Prot
      A2ANZ0, Q69ZU8, Q6P1A8, Q8VHD9
      UniProtKB/TrEMBL
      A2ANY8
      Related
      ENSMUSP00000081802.2, ENSMUST00000084750.8
      Conserved Domains (3) summary
      PHA03095
      Location:29 → 265
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:41 → 72
      ANK; ANK repeat [structural motif]
      pfam11179
      Location:520 → 643
      DUF2967; Protein of unknown function (DUF2967)

    3. NM_001355587.1 → NP_001342516.1  ankyrin repeat domain-containing protein 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
      Source sequence(s)
      AV290829, BC065177, CJ057243
      Consensus CDS
      CCDS18018.1
      UniProtKB/Swiss-Prot
      A2ANZ0, Q69ZU8, Q6P1A8, Q8VHD9
      UniProtKB/TrEMBL
      A2ANY8
      Conserved Domains (3) summary
      PHA03095
      Location:29 → 265
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:41 → 72
      ANK; ANK repeat [structural motif]
      pfam11179
      Location:520 → 643
      DUF2967; Protein of unknown function (DUF2967)

    4. NM_080471.3 → NP_536719.2  ankyrin repeat domain-containing protein 6

      See identical proteins and their annotated locations for NP_536719.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
      Source sequence(s)
      AV290829, BC065177, CF531081
      Consensus CDS
      CCDS18018.1
      UniProtKB/Swiss-Prot
      A2ANZ0, Q69ZU8, Q6P1A8, Q8VHD9
      UniProtKB/TrEMBL
      A2ANY8
      Related
      ENSMUSP00000081801.2, ENSMUST00000084749.8
      Conserved Domains (3) summary
      PHA03095
      Location:29 → 265
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:41 → 72
      ANK; ANK repeat [structural motif]
      pfam11179
      Location:520 → 643
      DUF2967; Protein of unknown function (DUF2967)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      32804027..32950884 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163674.1 → XP_036019567.1  ankyrin repeat domain-containing protein 6 isoform X4

      UniProtKB/TrEMBL
      A2ANY8
      Conserved Domains (2) summary
      PHA03095
      Location:19 → 232
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:107 → 138
      ANK; ANK repeat [structural motif]

    2. XM_036163672.1 → XP_036019565.1  ankyrin repeat domain-containing protein 6 isoform X2

      UniProtKB/TrEMBL
      A2ANY8
      Conserved Domains (2) summary
      PHA03095
      Location:19 → 232
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:107 → 138
      ANK; ANK repeat [structural motif]

    3. XM_036163673.1 → XP_036019566.1  ankyrin repeat domain-containing protein 6 isoform X3

      UniProtKB/TrEMBL
      A2ANY8
      Conserved Domains (2) summary
      PHA03095
      Location:29 → 265
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:41 → 72
      ANK; ANK repeat [structural motif]

    4. XM_036163675.1 → XP_036019568.1  ankyrin repeat domain-containing protein 6 isoform X5

      Conserved Domains (2) summary
      sd00045
      Location:18 → 48
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:22 → 114
      Ank_2; Ankyrin repeats (3 copies)

    5. XM_011249919.4 → XP_011248221.1  ankyrin repeat domain-containing protein 6 isoform X1

      See identical proteins and their annotated locations for XP_011248221.1

      UniProtKB/Swiss-Prot
      A2ANZ0, Q69ZU8, Q6P1A8, Q8VHD9
      UniProtKB/TrEMBL
      A2ANY8
      Conserved Domains (3) summary
      PHA03095
      Location:29 → 265
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:41 → 72
      ANK; ANK repeat [structural motif]
      pfam11179
      Location:520 → 643
      DUF2967; Protein of unknown function (DUF2967)

    6. XM_011249921.4 → XP_011248223.1  ankyrin repeat domain-containing protein 6 isoform X1

      See identical proteins and their annotated locations for XP_011248223.1

      UniProtKB/Swiss-Prot
      A2ANZ0, Q69ZU8, Q6P1A8, Q8VHD9
      UniProtKB/TrEMBL
      A2ANY8
      Conserved Domains (3) summary
      PHA03095
      Location:29 → 265
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:41 → 72
      ANK; ANK repeat [structural motif]
      pfam11179
      Location:520 → 643
      DUF2967; Protein of unknown function (DUF2967)

    7. XM_011249920.4 → XP_011248222.1  ankyrin repeat domain-containing protein 6 isoform X1

      See identical proteins and their annotated locations for XP_011248222.1

      UniProtKB/Swiss-Prot
      A2ANZ0, Q69ZU8, Q6P1A8, Q8VHD9
      UniProtKB/TrEMBL
      A2ANY8
      Conserved Domains (3) summary
      PHA03095
      Location:29 → 265
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:41 → 72
      ANK; ANK repeat [structural motif]
      pfam11179
      Location:520 → 643
      DUF2967; Protein of unknown function (DUF2967)

    8. XM_011249924.4 → XP_011248226.1  ankyrin repeat domain-containing protein 6 isoform X1

      See identical proteins and their annotated locations for XP_011248226.1

      UniProtKB/Swiss-Prot
      A2ANZ0, Q69ZU8, Q6P1A8, Q8VHD9
      UniProtKB/TrEMBL
      A2ANY8
      Conserved Domains (3) summary
      PHA03095
      Location:29 → 265
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:41 → 72
      ANK; ANK repeat [structural motif]
      pfam11179
      Location:520 → 643
      DUF2967; Protein of unknown function (DUF2967)

    9. XM_011249922.4 → XP_011248224.1  ankyrin repeat domain-containing protein 6 isoform X1

      See identical proteins and their annotated locations for XP_011248224.1

      UniProtKB/Swiss-Prot
      A2ANZ0, Q69ZU8, Q6P1A8, Q8VHD9
      UniProtKB/TrEMBL
      A2ANY8
      Conserved Domains (3) summary
      PHA03095
      Location:29 → 265
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:41 → 72
      ANK; ANK repeat [structural motif]
      pfam11179
      Location:520 → 643
      DUF2967; Protein of unknown function (DUF2967)

    10. XM_011249923.4 → XP_011248225.1  ankyrin repeat domain-containing protein 6 isoform X1

      See identical proteins and their annotated locations for XP_011248225.1

      UniProtKB/Swiss-Prot
      A2ANZ0, Q69ZU8, Q6P1A8, Q8VHD9
      UniProtKB/TrEMBL
      A2ANY8
      Conserved Domains (3) summary
      PHA03095
      Location:29 → 265
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:41 → 72
      ANK; ANK repeat [structural motif]
      pfam11179
      Location:520 → 643
      DUF2967; Protein of unknown function (DUF2967)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q69ZU8.2 GenPept UniProtKB/Swiss-Prot:Q69ZU8

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