Hmg20a high mobility group 20A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hmg20aprovided by MGI
Official Full Name: high mobility group 20Aprovided by MGI
Primary source: MGI:MGI:1914117
See related: Ensembl:ENSMUSG00000032329 AllianceGenome:MGI:1914117
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ibraf; Hmgxb1; 1200004E06Rik; 5730490E10Rik
Summary: Predicted to enable identical protein binding activity. Acts upstream of or within negative regulation of neuron differentiation; negative regulation of protein sumoylation; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including axial skeleton; early conceptus; genitourinary system; gut; and nervous system. Orthologous to human HMG20A (high mobility group 20A). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 21.5), whole brain E14.5 (RPKM 21.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 B; 9 30.13 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (56325891..56404220)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (56418619..56496936)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The metabesity factor HMG20A potentiates astrocyte survival and reactive astrogliosis preserving neuronal integrity.
Title: The metabesity factor HMG20A potentiates astrocyte survival and reactive astrogliosis preserving neuronal integrity.
HMG20A is a key regulator of mature beta cell function in type 2 diabetes mellitus.
Title: The type 2 diabetes-associated HMG20A gene is mandatory for islet beta cell functional maturity.
ectopic expression of BRAP2 inhibits nuclear localization of HMG20A and NuMA1, and prevents nuclear envelope accumulation of SYNE2.
Title: The BRCA1-binding protein BRAP2 can act as a cytoplasmic retention factor for nuclear and nuclear envelope-localizing testicular proteins.
beta-dystrobrevin interacts with the HMG20 proteins iBRAF and BRAF35
Title: The interaction with HMG20a/b proteins suggests a potential role for beta-dystrobrevin in neuronal differentiation.
Ectopic expression of iBRAF induces neuronal differentiation through recruitment of MLL, resulting in increased histone H3K4 trimethylation and activation of neuronal-specific genes.
Title: Recruitment of MLL by HMG-domain protein iBRAF promotes neural differentiation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:225343

RH124829 (e-PCR)
- UniSTS:161651

BE692142 (e-PCR)
- UniSTS:208382

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of protein sumoylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: high mobility group protein 20A

Names: HMG box-containing protein 20A; HMG domain-containing protein HMGX1; inhibitor of BRAF35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025812.3 → NP_080088.1 high mobility group protein 20A

See identical proteins and their annotated locations for NP_080088.1

Status: VALIDATED

Source sequence(s)

AC159819

Consensus CDS

CCDS23208.1

UniProtKB/Swiss-Prot

Q3LSF9, Q6NV87, Q8BSK1, Q8C3C1, Q8CAA0, Q9CYG2, Q9DC33

Related

ENSMUSP00000034879.4, ENSMUST00000034879.5

Conserved Domains (2) summary

cd01390
Location:102 → 167

HMGB-UBF_HMG-box; class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone chromosomal ...

pfam17380
Location:76 → 312

DUF5401; Family of unknown function (DUF5401)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

56325891..56404220

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155195.1 → XP_036011088.1 high mobility group protein 20A isoform X1

UniProtKB/Swiss-Prot

Q3LSF9, Q6NV87, Q8BSK1, Q8C3C1, Q8CAA0, Q9CYG2, Q9DC33

Conserved Domains (2) summary

cd01390
Location:102 → 167

HMGB-UBF_HMG-box; class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone chromosomal ...

pfam17380
Location:76 → 312

DUF5401; Family of unknown function (DUF5401)