Atp2b2 ATPase, Ca++ transporting, plasma membrane 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Atp2b2provided by MGI
Official Full Name: ATPase, Ca++ transporting, plasma membrane 2provided by MGI
Primary source: MGI:MGI:105368
See related: Ensembl:ENSMUSG00000030302 AllianceGenome:MGI:105368
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tmy; dfw; jog; wms; wri; PMCA2; D6Abb2e; Gena300
Summary: Enables calcium-dependent ATPase activity. Involved in calcium ion transport; cochlea development; and regulation of cytosolic calcium ion concentration. Acts upstream of or within several processes, including detection of mechanical stimulus involved in sensory perception of sound; lactation; and neuron differentiation. Located in several cellular components, including apical plasma membrane; endoplasmic reticulum; and neuronal cell body. Is active in glutamatergic synapse; photoreceptor ribbon synapse; and presynaptic membrane. Is expressed in heart; labyrinthine zone; liver; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness and autosomal recessive nonsyndromic deafness 12. Orthologous to human ATP2B2 (ATPase plasma membrane Ca2+ transporting 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in cortex adult (RPKM 49.9), cerebellum adult (RPKM 49.7) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 E3; 6 52.85 cM

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (113720803..114019574, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (113743831..114042613, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ATP2B2 de novo variants as a cause of variable neurodevelopmental disorders that feature dystonia, ataxia, intellectual disability, behavioral symptoms, and seizures.
Title: ATP2B2 de novo variants as a cause of variable neurodevelopmental disorders that feature dystonia, ataxia, intellectual disability, behavioral symptoms, and seizures.
Plasma Membrane Calcium ATPase-Neuroplastin Complexes Are Selectively Stabilized in GM1-Containing Lipid Rafts.
Title: Plasma Membrane Calcium ATPase-Neuroplastin Complexes Are Selectively Stabilized in GM1-Containing Lipid Rafts.
PMCA2 is a contributor to neuropathic pain mechanisms in the dorsal horn
Title: Pathological pain processing in mouse models of multiple sclerosis and spinal cord injury: contribution of plasma membrane calcium ATPase 2 (PMCA2).
Findings establish a novel, female-specific link between PMCA2, ERalpha and mechanical pain. It is postulated that PMCA2 is essential for adequate ERalpha signaling in the female dorsal horn and that impaired ERalpha signaling in the female PMCA2(+/-) mice hinders the analgesic effects of E2 leading to increased sensitivity to mechanical stimuli.
Title: A link between plasma membrane calcium ATPase 2 (PMCA2), estrogen and estrogen receptor α signaling in mechanical pain.
Early growth response protein 1 regulates promoter activity of alpha-plasma membrane calcium ATPase 2, a major calcium pump in the brain and auditory system
Title: Early growth response protein 1 regulates promoter activity of α-plasma membrane calcium ATPase 2, a major calcium pump in the brain and auditory system.
These findings indicate a novel role for PMCA2 in modality- and sex-dependent pain responsiveness. Female-specific molecular changes potentially account for the altered pain responses
Title: Impaired sensitivity to pain stimuli in plasma membrane calcium ATPase 2 (PMCA2) heterozygous mice: a possible modality- and sex-specific role for PMCA2 in nociception.
PMCA2 interacts with HER2 in specific actin-rich membrane domains.
Title: PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancer.
These results indicate that a significant fraction of the postsynaptic NMDAR current is reliant on a perisynaptic extracellular alkaline shift generated by the PMCA.
Title: Autocrine boost of NMDAR current in hippocampal CA1 pyramidal neurons by a PMCA-dependent, perisynaptic, extracellular pH shift.
Our results demonstrate that PMCA2 activity is an important regulator of the dendritic calcium equilibrium controlling Purkinje cell dendritic growth
Title: The plasma membrane Ca2+-ATPase2 (PMCA2) is involved in the regulation of Purkinje cell dendritic growth in cerebellar organotypic slice cultures.
This study further resolves the interaction between Atp2b2 and Cdh23 in a gene dosage and frequency-dependent manner, and finds that low auditory frequencies are significantly affected by the interaction.
Title: A new Atp2b2 deafwaddler allele, dfw(i5), interacts strongly with Cdh23 and other auditory modifiers.

Submit: New GeneRIF Correction See all GeneRIFs (35)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (8) 1 citation
Endonuclease-mediated (4)
Spontaneous (8) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D3S3990 (e-PCR)
- UniSTS:43011

D6Oda33 (e-PCR), detects polymorphism
- UniSTS:515331

D6Oda37 (e-PCR), detects polymorphism
- UniSTS:515332

Atp2b2 (e-PCR), detects polymorphism
- UniSTS:141130

43.MMHAP59FLG4.seq (e-PCR)
- UniSTS:124504

D3S2930E (e-PCR)
- UniSTS:150914

Atp2b2 (e-PCR), detects polymorphism
- UniSTS:532112

RH141415 (e-PCR)
- UniSTS:223409

34.MMHAP88FRD10.seq (e-PCR)
- UniSTS:124115

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables P-type calcium transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables P-type calcium transporter activity	ISO Inferred from Sequence Orthology more info
enables P-type calcium transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables P-type calcium transporter activity	TAS Traceable Author Statement more info
enables P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables PDZ domain binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium-dependent ATPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	ISS Inferred from Sequence or Structural Similarity more info
enables glutamate receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within auditory receptor cell stereocilium organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cGMP metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebellar Purkinje cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebellar Purkinje cell layer morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebellar granule cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebellum development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cochlea development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear receptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lactation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuromuscular process controlling balance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within organelle organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within otolith mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sensory perception of sound	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within serotonin metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic spine membrane	ISO Inferred from Sequence Orthology more info
located_in dendritic spine membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body membrane	ISO Inferred from Sequence Orthology more info
is_active_in parallel fiber to Purkinje cell synapse	ISO Inferred from Sequence Orthology more info
is_active_in photoreceptor ribbon synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: plasma membrane calcium-transporting ATPase 2

Names: deaf waddler; plasma membrane calcium ATPase; plasma membrane calcium pump; wriggle

NP_001031761.1

EC 7.2.2.10

NP_001334294.1

EC 7.2.2.10

NP_001396452.1

EC 7.2.2.10

NP_001396453.1

EC 7.2.2.10

NP_001396455.1

EC 7.2.2.10

NP_001396458.1

EC 7.2.2.10

NP_001396462.1

EC 7.2.2.10

NP_001396463.1

EC 7.2.2.10

NP_001396464.1

EC 7.2.2.10

NP_001396465.1

EC 7.2.2.10

NP_001396466.1

EC 7.2.2.10

NP_033853.1

EC 7.2.2.10

XP_011239463.1

EC 7.2.2.10

XP_011239464.1

EC 7.2.2.10

XP_011239468.1

EC 7.2.2.10

XP_011239469.1

EC 7.2.2.10

XP_011239470.1

EC 7.2.2.10

XP_011239471.1

EC 7.2.2.10

XP_011239472.1

EC 7.2.2.10

XP_030110979.1

EC 7.2.2.10

XP_030110980.1

EC 7.2.2.10

XP_030110982.1

EC 7.2.2.10

XP_036021655.1

EC 7.2.2.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001036684.4 → NP_001031761.1 plasma membrane calcium-transporting ATPase 2 isoform 1

See identical proteins and their annotated locations for NP_001031761.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding region, compared to variant 3. These differences result in a shorter protein (isoform 1), compared to isoform 2. Variants 1, 2, 6, and 7 all encode the same isoform (1).

Source sequence(s)

AC117596

Consensus CDS

CCDS20433.1

UniProtKB/Swiss-Prot

O88863, Q9R0K7

UniProtKB/TrEMBL

D5L240, Q3UHJ3

Related

ENSMUSP00000086398.6, ENSMUST00000089003.12

Conserved Domains (2) summary

TIGR01517
Location:12 → 1042

ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase

pfam12424
Location:1081 → 1127

ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
NM_001347365.2 → NP_001334294.1 plasma membrane calcium-transporting ATPase 2 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (3) encodes isoform 2. Variants 3 and 4 both encode the same isoform (2).

Source sequence(s)

AC117596, AC153590

Consensus CDS

CCDS85130.1

UniProtKB/TrEMBL

D5L240, F8WHB1

Related

ENSMUSP00000098605.3, ENSMUST00000101044.9

Conserved Domains (2) summary

TIGR01517
Location:12 → 1087

ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase

pfam12424
Location:1126 → 1172

ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
NM_001409523.1 → NP_001396452.1 plasma membrane calcium-transporting ATPase 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC117596

UniProtKB/TrEMBL

F8WHB1
NM_001409524.1 → NP_001396453.1 plasma membrane calcium-transporting ATPase 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC117596, AC153590
NM_001409526.1 → NP_001396455.1 plasma membrane calcium-transporting ATPase 2 isoform 1

Status: VALIDATED

Source sequence(s)

AC117596, AC153590

UniProtKB/Swiss-Prot

O88863, Q9R0K7

UniProtKB/TrEMBL

Q3UHJ3
NM_001409529.1 → NP_001396458.1 plasma membrane calcium-transporting ATPase 2 isoform 1

Status: VALIDATED

Source sequence(s)

AC117596, AC153590

UniProtKB/Swiss-Prot

O88863, Q9R0K7

UniProtKB/TrEMBL

Q3UHJ3
NM_001409533.1 → NP_001396462.1 plasma membrane calcium-transporting ATPase 2 isoform 4

Status: VALIDATED

Source sequence(s)

AC117596

UniProtKB/TrEMBL

Q3UHH0

Related

ENSMUSP00000145174.2, ENSMUST00000205052.3
NM_001409534.1 → NP_001396463.1 plasma membrane calcium-transporting ATPase 2 isoform 5

Status: VALIDATED

Source sequence(s)

AC117596
NM_001409535.1 → NP_001396464.1 plasma membrane calcium-transporting ATPase 2 isoform 6

Status: VALIDATED

Source sequence(s)

AC117596
NM_001409536.1 → NP_001396465.1 plasma membrane calcium-transporting ATPase 2 isoform 7

Status: VALIDATED

Source sequence(s)

AC117596

UniProtKB/TrEMBL

S4R1C4
NM_001409537.1 → NP_001396466.1 plasma membrane calcium-transporting ATPase 2 isoform 7

Status: VALIDATED

Source sequence(s)

AC117596

UniProtKB/TrEMBL

S4R1C4
NM_009723.7 → NP_033853.1 plasma membrane calcium-transporting ATPase 2 isoform 1

See identical proteins and their annotated locations for NP_033853.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR and coding region, compared to variant 3. These differences result in a shorter protein (isoform 1), compared to isoform 2. Variants 1, 2, 6, and 7 all encode the same isoform (1).

Source sequence(s)

AC117596, AC153590

Consensus CDS

CCDS20433.1

UniProtKB/Swiss-Prot

O88863, Q9R0K7

UniProtKB/TrEMBL

D5L240, Q3UHJ3

Related

ENSMUSP00000098606.4, ENSMUST00000101045.10

Conserved Domains (2) summary

TIGR01517
Location:12 → 1042

ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase

pfam12424
Location:1081 → 1127

ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

RNA

NR_176856.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC117596, AC153590

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

113720803..114019574 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011241161.1 → XP_011239463.1 plasma membrane calcium-transporting ATPase 2 isoform X1

See identical proteins and their annotated locations for XP_011239463.1

UniProtKB/TrEMBL

D5L240, F8WHB1

Conserved Domains (2) summary

TIGR01517
Location:12 → 1087

ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase

pfam12424
Location:1126 → 1172

ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
XM_011241167.3 → XP_011239469.1 plasma membrane calcium-transporting ATPase 2 isoform X4

UniProtKB/TrEMBL

D5L240

Conserved Domains (2) summary

TIGR01517
Location:12 → 1087

ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase

pfam12424
Location:1126 → 1168

ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
XM_011241168.2 → XP_011239470.1 plasma membrane calcium-transporting ATPase 2 isoform X5

UniProtKB/TrEMBL

D5L240

Conserved Domains (2) summary

TIGR01517
Location:12 → 1087

ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase

pfam12424
Location:1126 → 1168

ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
XM_030255122.2 → XP_030110982.1 plasma membrane calcium-transporting ATPase 2 isoform X10

UniProtKB/TrEMBL

D5L240

Conserved Domains (2) summary

TIGR01517
Location:12 → 1087

ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase

pfam12424
Location:1126 → 1201

ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
XM_011241162.4 → XP_011239464.1 plasma membrane calcium-transporting ATPase 2 isoform X1

See identical proteins and their annotated locations for XP_011239464.1

UniProtKB/TrEMBL

D5L240, F8WHB1

Conserved Domains (2) summary

TIGR01517
Location:12 → 1087

ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase

pfam12424
Location:1126 → 1172

ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
XM_011241166.4 → XP_011239468.1 plasma membrane calcium-transporting ATPase 2 isoform X3

UniProtKB/TrEMBL

D5L240

Conserved Domains (2) summary

TIGR01517
Location:12 → 1056

ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase

pfam12424
Location:1095 → 1141

ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
XM_030255120.2 → XP_030110980.1 plasma membrane calcium-transporting ATPase 2 isoform X3

UniProtKB/TrEMBL

D5L240

Conserved Domains (2) summary

TIGR01517
Location:12 → 1056

ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase

pfam12424
Location:1095 → 1141

ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
XM_030255119.2 → XP_030110979.1 plasma membrane calcium-transporting ATPase 2 isoform X2

UniProtKB/TrEMBL

D5L240

Conserved Domains (2) summary

TIGR01517
Location:12 → 1073

ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase

pfam12424
Location:1112 → 1158

ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
XM_036165762.1 → XP_036021655.1 plasma membrane calcium-transporting ATPase 2 isoform X9

UniProtKB/TrEMBL

D5L240, S4R1C4

Related

ENSMUSP00000138165.2, ENSMUST00000152831.8

Conserved Domains (2) summary

TIGR01517
Location:12 → 1042

ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase

pfam12424
Location:1081 → 1123

ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
XM_011241170.2 → XP_011239472.1 plasma membrane calcium-transporting ATPase 2 isoform X8

UniProtKB/TrEMBL

D5L240

Conserved Domains (2) summary

TIGR01517
Location:12 → 1042

ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase

pfam12424
Location:1081 → 1123

ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
XM_011241169.3 → XP_011239471.1 plasma membrane calcium-transporting ATPase 2 isoform X7

UniProtKB/TrEMBL

D5L240

Conserved Domains (2) summary

TIGR01517
Location:12 → 1056

ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase

pfam12424
Location:1095 → 1137

ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal