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    Acss2 acyl-CoA synthetase short-chain family member 2 [ Mus musculus (house mouse) ]

    Gene ID: 60525, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Acss2provided by MGI
    Official Full Name
    acyl-CoA synthetase short-chain family member 2provided by MGI
    Primary source
    MGI:MGI:1890410
    See related
    Ensembl:ENSMUSG00000027605 AllianceGenome:MGI:1890410
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ACS; ACAS; Acs1; Acas1; Acas2; aceCS; AceCS1; 1110017C11Rik
    Summary
    Enables CoA-ligase activity; chromatin binding activity; and transcription coactivator activity. Involved in long-term memory. Acts upstream of or within acetyl-CoA biosynthetic process. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; liver; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in orofacial cleft. Orthologous to human ACSS2 (acyl-CoA synthetase short chain family member 2). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in mammary gland adult (RPKM 107.5), subcutaneous fat pad adult (RPKM 101.3) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Acss2 in Genome Data Viewer
    Location:
    2 H1; 2 77.26 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (155359963..155404663)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (155518043..155562743)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene cytochrome c, somatic pseudogene Neighboring gene gamma-glutamyltransferase 7 Neighboring gene STARR-positive B cell enhancer ABC_E1258 Neighboring gene STARR-positive B cell enhancer ABC_E7875 Neighboring gene acyl-CoA synthetase short-chain family member 2, opposite strand Neighboring gene glutathione synthase, opposite strand 2 Neighboring gene glutathione synthetase Neighboring gene STARR-seq mESC enhancer starr_06145 Neighboring gene STARR-positive B cell enhancer ABC_E6005 Neighboring gene myosin, heavy chain 7B, cardiac muscle, beta Neighboring gene microRNA 499

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Targeting acetyl-CoA metabolism attenuates the formation of fear memories through reduced activity-dependent histone acetylation. Alexander DC, et al. Proc Natl Acad Sci U S A, 2022 Aug 9. PMID 35921439, Free PMC Article
    2. ACSS2 promotes systemic fat storage and utilization through selective regulation of genes involved in lipid metabolism. Huang Z, et al. Proc Natl Acad Sci U S A, 2018 Oct 2. PMID 30228117, Free PMC Article
    3. A substitution mutation in a conserved domain of mammalian acetate-dependent acetyl CoA synthetase 2 results in destabilized protein and impaired HIF-2 signaling. Nagati JS, et al. PLoS One, 2019. PMID 31725783, Free PMC Article
    4. Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma. Li Z, et al. Cell Metab, 2021 Jan 5. PMID 33406405, Free PMC Article
    5. Nuclear-cytoplasmic localization of acetyl coenzyme a synthetase-1 in the rat brain. Ariyannur PS, et al. J Comp Neurol, 2010 Aug 1. PMID 20533355, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-glycosylation of SCAP exacerbates hepatocellular inflammation and lipid accumulation via ACSS2-mediated histone H3K27 acetylation.
      Title: N-glycosylation of SCAP exacerbates hepatocellular inflammation and lipid accumulation via ACSS2-mediated histone H3K27 acetylation.
    2. Acetyl-CoA synthetase 2 induces pyroptosis and inflammation of renal epithelial tubular cells in sepsis-induced acute kidney injury by upregulating the KLF5/NF-kappaB pathway.
      Title: Acetyl-CoA synthetase 2 induces pyroptosis and inflammation of renal epithelial tubular cells in sepsis-induced acute kidney injury by upregulating the KLF5/NF-κB pathway.
    3. Gut microbiota regulates hepatic ischemia-reperfusion injury-induced cognitive dysfunction via the HDAC2-ACSS2 axis in mice.
      Title: Gut microbiota regulates hepatic ischemia-reperfusion injury-induced cognitive dysfunction via the HDAC2-ACSS2 axis in mice.
    4. Inhibition of ACSS2 attenuates alcoholic liver steatosis via epigenetically regulating de novo lipogenesis.
      Title: Inhibition of ACSS2 attenuates alcoholic liver steatosis via epigenetically regulating de novo lipogenesis.
    5. ACSS2-dependent histone acetylation improves cognition in mouse model of Alzheimer's disease.
      Title: ACSS2-dependent histone acetylation improves cognition in mouse model of Alzheimer's disease.
    6. Acss2 Deletion Reveals Functional Versatility via Tissue-Specific Roles in Transcriptional Regulation.
      Title: Acss2 Deletion Reveals Functional Versatility via Tissue-Specific Roles in Transcriptional Regulation.
    7. Targeting acetyl-CoA metabolism attenuates the formation of fear memories through reduced activity-dependent histone acetylation.
      Title: Targeting acetyl-CoA metabolism attenuates the formation of fear memories through reduced activity-dependent histone acetylation.
    8. Mammalian acetate-dependent acetyl CoA synthetase 2 contains multiple protein destabilization and masking elements.
      Title: Mammalian acetate-dependent acetyl CoA synthetase 2 contains multiple protein destabilization and masking elements.
    9. Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma.
      Title: Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma.
    10. Different Effects of Knockouts in ALDH2 and ACSS2 on Embryonic Stem Cell Differentiation.
      Title: Different Effects of Knockouts in ALDH2 and ACSS2 on Embryonic Stem Cell Differentiation.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: Gssos2

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acetate-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetate-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acetate-CoA ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables acetate-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables propionate-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in acetate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in acetyl-CoA biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within acetyl-CoA biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in propionate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    acetyl-coenzyme A synthetase, cytoplasmic
    Names
    acetate--CoA ligase
    acetyl-CoA synthetase 1
    acetyl-Coenzyme A synthetase 1 (AMP forming)
    acetyl-Coenzyme A synthetase 2 (ADP forming)
    acetyl-Coenzyme A synthetase 2 (AMP forming)
    acyl-activating enzyme
    propionate--CoA ligase
    NP_062785.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019811.3 → NP_062785.2  acetyl-coenzyme A synthetase, cytoplasmic

      See identical proteins and their annotated locations for NP_062785.2

      Status: VALIDATED

      Source sequence(s)
      AL844852
      Consensus CDS
      CCDS16950.1
      UniProtKB/Swiss-Prot
      Q8BK97, Q9QXG4
      UniProtKB/TrEMBL
      Q8C141, Q8C1A8
      Related
      ENSMUSP00000029135.9, ENSMUST00000029135.15
      Conserved Domains (1) summary
      cd05966
      Location:45 → 685
      ACS; Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      155359963..155404663
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QXG4.2 GenPept UniProtKB/Swiss-Prot:Q9QXG4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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