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    Fto FTO alpha-ketoglutarate dependent dioxygenase [ Mus musculus (house mouse) ]

    Gene ID: 26383, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Ftoprovided by MGI
    Official Full Name
    FTO alpha-ketoglutarate dependent dioxygenaseprovided by MGI
    Primary source
    MGI:MGI:1347093
    See related
    Ensembl:ENSMUSG00000055932 AllianceGenome:MGI:1347093
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1752
    Summary
    Enables broad specificity oxidative DNA demethylase activity and oxidative RNA demethylase activity. Involved in several processes, including DNA alkylation repair; RNA repair; and regulation of respiratory system process. Located in nucleus. Is expressed in several structures, including alimentary system; cerebral cortex; gonad; hemolymphoid system gland; and liver. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetic neuropathy; nuclear senile cataract; renal cell carcinoma (multiple); and type 2 diabetes mellitus. Orthologous to human FTO (FTO alpha-ketoglutarate dependent dioxygenase). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 31.5), whole brain E14.5 (RPKM 30.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fto in Genome Data Viewer
    Location:
    8 C5; 8 44.34 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (92039995..92395061)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (91313367..91668433)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene Rpgrip1-like Neighboring gene abhydrolase domain containing 10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_22299 Neighboring gene predicted gene, 36163 Neighboring gene RIKEN cDNA 4831440D22 gene Neighboring gene STARR-seq mESC enhancer starr_22306 Neighboring gene STARR-seq mESC enhancer starr_22308 Neighboring gene uncharacterized LOC118567558 Neighboring gene STARR-seq mESC enhancer starr_22309 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Fto Gene Regulates the Proliferation and Differentiation of Pre-Adipocytes in Vitro. Jiao Y, et al. Nutrients, 2016 Feb 19. PMID 26907332, Free PMC Article
    2. Signs of cardiac autonomic imbalance and proarrhythmic remodeling in FTO deficient mice. Carnevali L, et al. PLoS One, 2014. PMID 24743632, Free PMC Article
    3. Cerebroprotective Role of N(6)-Methyladenosine Demethylase FTO (Fat Mass and Obesity-Associated Protein) After Experimental Stroke. Chokkalla AK, et al. Stroke, 2023 Jan. PMID 36321453, Free PMC Article
    4. m(6) A demethylase Fto regulates the TNF-α-induced inflammatory response in cementoblasts. Li B, et al. Oral Dis, 2023 Oct. PMID 36227651
    5. The m(6)A demethylase FTO promotes renal epithelial-mesenchymal transition by reducing the m(6)A modification of lncRNA GAS5. Li X, et al. Cytokine, 2022 Nov. PMID 36058192

    See all (160) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FTO mediates the diabetic kidney disease progression through regulating the m[6]A modification of NLRP3.
      Title: FTO mediates the diabetic kidney disease progression through regulating the m(6)A modification of NLRP3.
    2. The m[6]A eraser FTO suppresses ferroptosis via mediating ACSL4 in LPS-induced macrophage inflammation.
      Title: The m(6)A eraser FTO suppresses ferroptosis via mediating ACSL4 in LPS-induced macrophage inflammation.
    3. FTO Deficiency Alleviates LPS-induced Acute Lung Injury by TXNIP/NLRP3-mediated Alveolar Epithelial Cell Pyroptosis.
      Title: FTO Deficiency Alleviates LPS-induced Acute Lung Injury by TXNIP/NLRP3-mediated Alveolar Epithelial Cell Pyroptosis.
    4. The role of the m6A/m demethylase FTO in memory is both task and sex-dependent in mice.
      Title: The role of the m6A/m demethylase FTO in memory is both task and sex-dependent in mice.
    5. MicroRNA-192-5p downregulates Fat Mass and Obesity-associated Protein to aggravate renal ischemia/reperfusion injury.
      Title: MicroRNA-192-5p downregulates Fat Mass and Obesity-associated Protein to aggravate renal ischemia/reperfusion injury.
    6. FTO regulates osteoclast development by modulating the proliferation and apoptosis of osteoclast precursors in inflammatory conditions.
      Title: FTO regulates osteoclast development by modulating the proliferation and apoptosis of osteoclast precursors in inflammatory conditions.
    7. A novel PDIA3/FTO/USP20 positive feedback regulatory loop induces osteogenic differentiation of preosteoblast in osteoporosis.
      Title: A novel PDIA3/FTO/USP20 positive feedback regulatory loop induces osteogenic differentiation of preosteoblast in osteoporosis.
    8. Fat mass and obesity associated protein inhibits neuronal ferroptosis via the FYN/Drp1 axis and alleviate cerebral ischemia/reperfusion injury.
      Title: Fat mass and obesity associated protein inhibits neuronal ferroptosis via the FYN/Drp1 axis and alleviate cerebral ischemia/reperfusion injury.
    9. FTO-mediated m6A mRNA demethylation aggravates renal fibrosis by targeting RUNX1 and further enhancing PI3K/AKT pathway.
      Title: FTO-mediated m6A mRNA demethylation aggravates renal fibrosis by targeting RUNX1 and further enhancing PI3K/AKT pathway.
    10. Oxidative stress-mediated activation of FTO exacerbates impairment of the epithelial barrier by up-regulating IKBKB via N6-methyladenosine-dependent mRNA stability in asthmatic mice exposed to PM2.5.
      Title: Oxidative stress-mediated activation of FTO exacerbates impairment of the epithelial barrier by up-regulating IKBKB via N6-methyladenosine-dependent mRNA stability in asthmatic mice exposed to PM2.5.
    Submit: New GeneRIF Correction See all GeneRIFs (105)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 2-oxoglutarate-dependent dioxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables broad specificity oxidative DNA demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables broad specificity oxidative DNA demethylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables broad specificity oxidative DNA demethylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ferrous iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ferrous iron binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ferrous iron binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables mRNA N6-methyladenosine dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA N6-methyladenosine dioxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA N6-methyladenosine dioxygenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidative RNA demethylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidative RNA demethylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA demethylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA demethylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA alkylation repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA alkylation repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in RNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adipose tissue development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA destabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of eating behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of brown fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of brown fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of lipid storage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of respiratory system process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of white fat cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in snRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in temperature homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    alpha-ketoglutarate-dependent dioxygenase FTO
    Names
    U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO
    U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO
    fat mass and obesity associated
    fat mass and obesity-associated protein
    m6A(m)-demethylase FTO
    mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO
    mRNA N(6)-methyladenosine demethylase FTO
    protein fatso
    tRNA N1-methyl adenine demethylase FTO
    NP_036066.2
    XP_006531099.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011936.2 → NP_036066.2  alpha-ketoglutarate-dependent dioxygenase FTO

      See identical proteins and their annotated locations for NP_036066.2

      Status: VALIDATED

      Source sequence(s)
      BC057008, BY290198, CA321822
      Consensus CDS
      CCDS22521.1
      UniProtKB/Swiss-Prot
      Q3TTZ5, Q6ZPI7, Q8BGW1, Q8BR68, Q8CB66, Q8R250, Q9QZ13
      Related
      ENSMUSP00000068380.8, ENSMUST00000069718.15
      Conserved Domains (2) summary
      pfam12933
      Location:36 → 322
      FTO_NTD; FTO catalytic domain
      pfam12934
      Location:326 → 495
      FTO_CTD; FTO C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      92039995..92395061
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531036.2 → XP_006531099.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X1

      UniProtKB/TrEMBL
      E9Q1E4
      Conserved Domains (1) summary
      pfam12933
      Location:40 → 252
      FTO_NTD; FTO catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGW1.1 GenPept UniProtKB/Swiss-Prot:Q8BGW1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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