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    Hkdc1 hexokinase domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 216019, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Hkdc1provided by MGI
    Official Full Name
    hexokinase domain containing 1provided by MGI
    Primary source
    MGI:MGI:2384910
    See related
    Ensembl:ENSMUSG00000020080 AllianceGenome:MGI:2384910
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable fructokinase activity and glucokinase activity. Involved in intracellular glucose homeostasis. Located in photoreceptor inner segment. Is expressed in several structures, including alimentary system; central nervous system; limb; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in retinitis pigmentosa. Orthologous to human HKDC1 (hexokinase domain containing 1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in large intestine adult (RPKM 26.1), small intestine adult (RPKM 24.2) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hkdc1 in Genome Data Viewer
    Location:
    10 B4; 10 32.4 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (62218916..62259490, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (62383137..62423711, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene tachykinin receptor 2 Neighboring gene hexokinase 1 Neighboring gene STARR-seq mESC enhancer starr_26881 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:61802071-61802272 Neighboring gene STARR-positive B cell enhancer ABC_E9791 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:61803279-61803470 Neighboring gene hexokinase 1, opposite strand Neighboring gene STARR-seq mESC enhancer starr_26882 Neighboring gene predicted gene, 30322 Neighboring gene suppressor of var1, 3-like 1 (S. cerevisiae) Neighboring gene RIKEN cDNA 4930507D05 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:61912425-61912612 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:61912686-61912869 Neighboring gene VPS26 retromer complex component A Neighboring gene STARR-seq mESC enhancer starr_26885 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:61949721-61949830

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Enterocyte HKDC1 Modulates Intestinal Glucose Absorption in Male Mice Fed a High-fat Diet. Zapater JL, et al. Endocrinology, 2022 Jun 1. PMID 35435980, Free PMC Article
    2. Liver-specific overexpression of HKDC1 increases hepatocyte size and proliferative capacity. Pusec CM, et al. Sci Rep, 2023 May 17. PMID 37198225, Free PMC Article
    3. The hexokinase "HKDC1" interaction with the mitochondria is essential for liver cancer progression. Khan MW, et al. Cell Death Dis, 2022 Jul 28. PMID 35902556, Free PMC Article
    4. The Role of Hexokinase Domain Containing Protein-1 in Glucose Regulation During Pregnancy. Zapater JL, et al. Curr Diab Rep, 2021 Jul 7. PMID 34232412, Free PMC Article
    5. Whole-exome sequencing revealed HKDC1 as a candidate gene associated with autosomal-recessive retinitis pigmentosa. Zhang L, et al. Hum Mol Genet, 2018 Dec 1. PMID 30085091, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HKDC1 promotes tumor immune evasion in hepatocellular carcinoma by coupling cytoskeleton to STAT1 activation and PD-L1 expression.
      Title: HKDC1 promotes tumor immune evasion in hepatocellular carcinoma by coupling cytoskeleton to STAT1 activation and PD-L1 expression.
    2. Proteomics identifies the developmental regulation of HKDC1 in liver of pigs and mice.
      Title: Proteomics identifies the developmental regulation of HKDC1 in liver of pigs and mice.
    3. Liver-specific overexpression of HKDC1 increases hepatocyte size and proliferative capacity.
      Title: Liver-specific overexpression of HKDC1 increases hepatocyte size and proliferative capacity.
    4. The Role of Hexokinase Domain Containing Protein-1 in Glucose Regulation During Pregnancy.
      Title: The Role of Hexokinase Domain Containing Protein-1 in Glucose Regulation During Pregnancy.
    5. expression in hepatocytes results in defective mitochondrial function and altered hepatocellular metabolism
      Title: Hepatic HKDC1 Expression Contributes to Liver Metabolism.
    6. Hepatic HKDC1 contributes to whole body glucose disposal, insulin sensitivity, and aspects of nutrient balance during pregnancy.
      Title: Hepatic hexokinase domain containing 1 (HKDC1) improves whole body glucose tolerance and insulin sensitivity in pregnant mice.
    7. Taken together, our data demonstrated that HKDC1 is associated with autosomal recessively inherited Retinitis pigmentosa.
      Title: Whole-exome sequencing revealed HKDC1 as a candidate gene associated with autosomal-recessive retinitis pigmentosa.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4)  1 citation
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC28816

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables D-glucose binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fructokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucokinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glucokinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glucose 6-phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glucose 6-phosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glucose 6-phosphate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hexose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular glucose homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in photoreceptor inner segment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hexokinase HKDC1
    Names
    hexokinase domain-containing protein 1
    putative hexokinase HKDC1
    NP_663394.1
    XP_011241699.1
    XP_011241700.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145419.1 → NP_663394.1  hexokinase HKDC1

      See identical proteins and their annotated locations for NP_663394.1

      Status: PROVISIONAL

      Source sequence(s)
      BC016235
      Consensus CDS
      CCDS23888.1
      UniProtKB/Swiss-Prot
      Q3UKJ9, Q91W97
      Related
      ENSMUSP00000020277.9, ENSMUST00000020277.9
      Conserved Domains (3) summary
      PTZ00107
      Location:466 → 905
      PTZ00107; hexokinase; Provisional
      pfam00349
      Location:21 → 219
      Hexokinase_1
      pfam03727
      Location:225 → 459
      Hexokinase_2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      62218916..62259490 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243398.4 → XP_011241700.1  hexokinase HKDC1 isoform X2

      Conserved Domains (2) summary
      pfam00349
      Location:229 → 424
      Hexokinase_1
      pfam03727
      Location:430 → 664
      Hexokinase_2

    2. XM_011243397.3 → XP_011241699.1  hexokinase HKDC1 isoform X1

      Conserved Domains (2) summary
      pfam00349
      Location:469 → 664
      Hexokinase_1
      pfam03727
      Location:225 → 459
      Hexokinase_2

    RNA

    1. XR_004936154.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91W97.1 GenPept UniProtKB/Swiss-Prot:Q91W97

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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