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    Slco3a1 solute carrier organic anion transporter family, member 3a1 [ Mus musculus (house mouse) ]

    Gene ID: 108116, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Slco3a1provided by MGI
    Official Full Name
    solute carrier organic anion transporter family, member 3a1provided by MGI
    Primary source
    MGI:MGI:1351867
    See related
    Ensembl:ENSMUSG00000025790 AllianceGenome:MGI:1351867
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Anr1; MJAM; OATP-D; Slc21a11; 5830414C08Rik
    Summary
    Predicted to enable prostaglandin transmembrane transporter activity and sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in several processes, including positive regulation of NF-kappaB transcription factor activity; prostaglandin transport; and sodium-independent organic anion transport. Predicted to be located in basal plasma membrane. Predicted to be active in basolateral plasma membrane. Is expressed in nervous system and thyroid gland. Orthologous to human SLCO3A1 (solute carrier organic anion transporter family member 3A1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in lung adult (RPKM 34.1), ovary adult (RPKM 22.9) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slco3a1 in Genome Data Viewer
    Location:
    7 42.95 cM; 7 D1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (73925166..74204528, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (74275418..74554780, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 Neighboring gene STARR-seq mESC enhancer starr_19204 Neighboring gene STARR-seq mESC enhancer starr_19205 Neighboring gene alpha-enolase pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:81486370-81486479 Neighboring gene STARR-seq mESC enhancer starr_19206 Neighboring gene STARR-seq mESC enhancer starr_19207 Neighboring gene predicted gene, 53360 Neighboring gene predicted gene, 39037

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of androgen-regulated genes in mouse kidney by representational difference analysis and random arbitrarily primed polymerase chain reaction. Melià MJ, et al. Endocrinology, 1998 Feb. PMID 9449642
    2. Knockdown of DNMT1 Induces SLCO3A1 to Promote Follicular Growth by Enhancing the Proliferation of Granulosa Cells in Mammals. Li S, et al. Int J Mol Sci, 2024 Feb 20. PMID 38473715, Free PMC Article
    3. Solute Carrier Organic Anion Transporter Family Member 3A1 Is a Bile Acid Efflux Transporter in Cholestasis. Pan Q, et al. Gastroenterology, 2018 Nov. PMID 30063921, Free PMC Article
    4. Mice deficient in MCT8 reveal a mechanism regulating thyroid hormone secretion. Di Cosmo C, et al. J Clin Invest, 2010 Sep. PMID 20679730, Free PMC Article
    5. Weight loss after gastric bypass is associated with a variant at 15q26.1. Hatoum IJ, et al. Am J Hum Genet, 2013 May 2. PMID 23643386, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knockdown of DNMT1 Induces SLCO3A1 to Promote Follicular Growth by Enhancing the Proliferation of Granulosa Cells in Mammals.
      Title: Knockdown of DNMT1 Induces SLCO3A1 to Promote Follicular Growth by Enhancing the Proliferation of Granulosa Cells in Mammals.
    2. Expression of St8sia2 and Slco3a1 was significantly altered in metabolically active tissues in Roux-en-Y gastric bypass-treated compared to weight-matched, sham-operated mice.
      Title: Weight loss after gastric bypass is associated with a variant at 15q26.1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables organic anion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables organic anion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables prostaglandin transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables prostaglandin transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables sodium-independent organic anion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oligopeptide transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of NF-kappaB transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in prostaglandin transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in prostaglandin transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in prostaglandin transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sodium-independent organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in basal plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier organic anion transporter family member 3A1
    Names
    androgen regulated protein 1
    organic anion-transporting polypeptide D
    sodium-independent organic anion transporter D
    solute carrier family 21 (organic anion transporter), member 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038643.1 → NP_001033732.1  solute carrier organic anion transporter family member 3A1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes a 3' terminal exon that extends past a splice site used in variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC114591, AK031280, AK037938
      Consensus CDS
      CCDS21366.1
      UniProtKB/TrEMBL
      D3YXA8
      Related
      ENSMUSP00000095973.3, ENSMUST00000098371.9
      Conserved Domains (1) summary
      cd17402
      Location:39 → 563
      MFS_SLCO3_OATP3; Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of transporters

    2. NM_023908.2 → NP_076397.2  solute carrier organic anion transporter family member 3A1 isoform 1

      See identical proteins and their annotated locations for NP_076397.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      AK031280, AK046945, AK152488
      Consensus CDS
      CCDS21367.1
      UniProtKB/Swiss-Prot
      Q3TLX2, Q3U7W0, Q505P2, Q544H3, Q8R3L5, Q9CTV3, Q9JKV0
      UniProtKB/TrEMBL
      D3YXA8
      Related
      ENSMUSP00000026897.8, ENSMUST00000026897.14
      Conserved Domains (1) summary
      cd17402
      Location:39 → 563
      MFS_SLCO3_OATP3; Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of transporters

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      73925166..74204528 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R3L5.1 GenPept UniProtKB/Swiss-Prot:Q8R3L5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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