Dgkz diacylglycerol kinase zeta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dgkzprovided by MGI
Official Full Name: diacylglycerol kinase zetaprovided by MGI
Primary source: MGI:MGI:1278339
See related: Ensembl:ENSMUSG00000040479 AllianceGenome:MGI:1278339
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mDGK[z]; E130307B02Rik; F730209L11Rik
Summary: Enables ATP-dependent diacylglycerol kinase activity and enzyme inhibitor activity. Involved in several processes, including glycerolipid metabolic process; lipid phosphorylation; and maintenance of postsynaptic density structure. Acts upstream of or within negative regulation of Ras protein signal transduction. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Orthologous to human DGKZ (diacylglycerol kinase zeta). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Broad expression in thymus adult (RPKM 128.6), cerebellum adult (RPKM 47.0) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E1; 2 50.63 cM

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (91763167..91806788, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (91932822..91976443, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Diacylglycerol kinase zeta deficiency attenuates papain-induced type 2 airway inflammation.
Title: Diacylglycerol kinase zeta deficiency attenuates papain-induced type 2 airway inflammation.
Diacylglycerol kinase zeta limits IL-2-dependent control of PD-1 expression in tumor-infiltrating T lymphocytes.
Title: Diacylglycerol kinase ζ limits IL-2-dependent control of PD-1 expression in tumor-infiltrating T lymphocytes.
DGK alpha and zeta Activities Control TH1 and TH17 Cell Differentiation.
Title: DGK α and ζ Activities Control T(H)1 and T(H)17 Cell Differentiation.
Diacylglycerol kinase zeta promotes allergic airway inflammation and airway hyperresponsiveness through distinct mechanisms.
Title: Diacylglycerol kinase ζ promotes allergic airway inflammation and airway hyperresponsiveness through distinct mechanisms.
The Dgkzeta induction in arthritic conditions perpetuates systemic inflammatory responses mediated by macrophages and highlight a potential role of Dgkzeta-DAG/phosphatidic acid axis as a modulator of inflammatory cytokine production in sJIA and CSS.
Title: Diacylglycerol Kinase ζ Regulates Macrophage Responses in Juvenile Arthritis and Cytokine Storm Syndrome Mouse Models.
results implicate DGKzeta as a novel negative regulator of GPVI-mediated platelet activation that plays an important role in regulating thrombus formation in vivo.
Title: Diacylglycerol kinase ζ is a negative regulator of GPVI-mediated platelet activation.
Loss of DGK zeta expression is associated with muscle atrophy.
Title: A DGKζ-FoxO-ubiquitin proteolytic axis controls fiber size during skeletal muscle remodeling.
the results demonstrate that DGKzeta plays a sentinel role in p53 expression at the cellular and organismal levels after DNA damaging stress conditions.
Title: DGKζ ablation engenders upregulation of p53 level in the spleen upon whole-body ionizing radiation.
DGKzeta deficiency protects against peripheral insulin resistance and improves energy metabolism.
Title: DGKζ deficiency protects against peripheral insulin resistance and improves energy metabolism.
DGKzeta prevents GLUT4 translocation in the absence of insulin. DGKzeta dissociated from IRS-1 by insulin stimulation enhances GLUT4 translocation through PIP5K1alpha activity
Title: A novel IRS-1-associated protein, DGKζ regulates GLUT4 translocation in 3T3-L1 adipocytes.

Submit: New GeneRIF Correction See all GeneRIFs (51)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2Mit45 (e-PCR), detects polymorphism
- UniSTS:129360

D2Dcr50 (e-PCR), detects polymorphism
- UniSTS:507609

NoName (e-PCR)
- UniSTS:234463

Dgkz (e-PCR), detects polymorphism
- UniSTS:519409

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent diacylglycerol kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent diacylglycerol kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ATP-dependent diacylglycerol kinase activity	ISO Inferred from Sequence Orthology more info
enables alkylglycerol kinase activity	IEA Inferred from Electronic Annotation more info
enables enzyme inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables kinase activity	ISO Inferred from Sequence Orthology more info
enables lipid kinase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of Ras protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in diacylglycerol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in diacylglycerol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in diacylglycerol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycerolipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in maintenance of postsynaptic density structure	IDA Inferred from Direct Assay more info	PubMed
involved_in maintenance of postsynaptic density structure	IEP Inferred from Expression Pattern more info	PubMed
involved_in maintenance of postsynaptic density structure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic G1 DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of Ras protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of T cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in phosphatidic acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidic acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidic acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in glutamatergic synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: diacylglycerol kinase zeta

Names: DAG kinase zeta; DGK-zeta; diglyceride kinase zeta

NP_001160069.1

EC 2.7.1.107

EC 2.7.1.93

NP_612179.2

EC 2.7.1.107

EC 2.7.1.93

XP_006498600.1

EC 2.7.1.107

EC 2.7.1.93

XP_006498601.1

EC 2.7.1.107

EC 2.7.1.93

XP_006498602.1

EC 2.7.1.107

EC 2.7.1.93

XP_006498603.1

EC 2.7.1.107

EC 2.7.1.93

XP_006498604.1

EC 2.7.1.107

EC 2.7.1.93

XP_006498605.1

EC 2.7.1.107

EC 2.7.1.93

XP_006498606.1

EC 2.7.1.107

EC 2.7.1.93

XP_011237543.1

EC 2.7.1.107

EC 2.7.1.93

XP_011237546.1

EC 2.7.1.107

EC 2.7.1.93

XP_017170356.1

EC 2.7.1.107

EC 2.7.1.93

XP_017170364.1

EC 2.7.1.107

EC 2.7.1.93

XP_017170367.1

EC 2.7.1.107

EC 2.7.1.93

XP_030102338.1

EC 2.7.1.107

EC 2.7.1.93

XP_036013070.1

EC 2.7.1.107

EC 2.7.1.93

XP_036013088.1

EC 2.7.1.107

EC 2.7.1.93

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001166597.1 → NP_001160069.1 diacylglycerol kinase zeta isoform 1

See identical proteins and their annotated locations for NP_001160069.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AK087503, BE862117, BY545365, CD564532

Consensus CDS

CCDS50643.1

UniProtKB/TrEMBL

A2AHK0

Related

ENSMUSP00000106934.2, ENSMUST00000111303.2

Conserved Domains (7) summary

smart00045
Location:641 → 798

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:492 → 613

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

COG1597
Location:488 → 811

LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]

cd00204
Location:989 → 1105

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:989 → 1083

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:979 → 1015

ANK; ANK repeat [structural motif]

cl00040
Location:367 → 426

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
NM_138306.2 → NP_612179.2 diacylglycerol kinase zeta isoform 2

See identical proteins and their annotated locations for NP_612179.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an alternate 5' sequence, as compared to variant 1. The resulting isoform (2) is shorter and has a distinct N-terminus, as compared to isoform 1.

Source sequence(s)

AK087503, AK204403, BB834774, BQ443200, BY733951

Consensus CDS

CCDS16441.1

UniProtKB/Swiss-Prot

A2AHJ6, Q80UP3

Related

ENSMUSP00000028667.4, ENSMUST00000028667.10

Conserved Domains (7) summary

smart00045
Location:447 → 604

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:298 → 419

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

COG1597
Location:294 → 617

LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]

cd00204
Location:795 → 911

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:795 → 889

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:785 → 821

ANK; ANK repeat [structural motif]

cl00040
Location:173 → 232

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

91763167..91806788 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006498539.1 → XP_006498602.1 diacylglycerol kinase zeta isoform X4

Conserved Domains (5) summary

smart00045
Location:464 → 621

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:315 → 436

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

sd00045
Location:854 → 887

ANK; ANK repeat [structural motif]

pfam12796
Location:826 → 920

Ank_2; Ankyrin repeats (3 copies)

cl00040
Location:190 → 240

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
XM_006498541.3 → XP_006498604.1 diacylglycerol kinase zeta isoform X7

UniProtKB/TrEMBL

A2AHJ7

Related

ENSMUSP00000106937.3, ENSMUST00000099709.10

Conserved Domains (5) summary

smart00045
Location:464 → 621

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:315 → 436

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

sd00045
Location:802 → 838

ANK; ANK repeat [structural motif]

pfam12796
Location:812 → 906

Ank_2; Ankyrin repeats (3 copies)

cl00040
Location:190 → 240

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
XM_006498543.2 → XP_006498606.1 diacylglycerol kinase zeta isoform X10

UniProtKB/TrEMBL

A0A668KL90

Related

ENSMUSP00000159231.2, ENSMUST00000239257.2

Conserved Domains (5) summary

smart00045
Location:452 → 609

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:303 → 424

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

sd00045
Location:790 → 826

ANK; ANK repeat [structural motif]

pfam12796
Location:800 → 894

Ank_2; Ankyrin repeats (3 copies)

cl00040
Location:178 → 228

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
XM_036157177.1 → XP_036013070.1 diacylglycerol kinase zeta isoform X6

Conserved Domains (6) summary

smart00045
Location:452 → 609

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:303 → 424

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

sd00045
Location:841 → 874

ANK; ANK repeat [structural motif]

pfam12796
Location:813 → 907

Ank_2; Ankyrin repeats (3 copies)

cd20849
Location:93 → 166

C1_DGKzeta_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase zeta (DAG kinase zeta) and similar proteins

cd20895
Location:176 → 250

C1_DGKzeta_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase zeta (DAG kinase zeta) and similar proteins
XM_006498540.2 → XP_006498603.1 diacylglycerol kinase zeta isoform X5

Conserved Domains (5) summary

smart00045
Location:452 → 609

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:303 → 424

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

sd00045
Location:842 → 875

ANK; ANK repeat [structural motif]

pfam12796
Location:814 → 908

Ank_2; Ankyrin repeats (3 copies)

cl00040
Location:178 → 228

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
XM_030246478.2 → XP_030102338.1 diacylglycerol kinase zeta isoform X9

Conserved Domains (5) summary

smart00045
Location:447 → 604

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:298 → 419

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

sd00045
Location:836 → 869

ANK; ANK repeat [structural motif]

pfam12796
Location:808 → 902

Ank_2; Ankyrin repeats (3 copies)

cl00040
Location:173 → 223

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
XM_006498542.5 → XP_006498605.1 diacylglycerol kinase zeta isoform X8

Conserved Domains (5) summary

smart00045
Location:447 → 604

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:298 → 419

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

sd00045
Location:837 → 870

ANK; ANK repeat [structural motif]

pfam12796
Location:809 → 903

Ank_2; Ankyrin repeats (3 copies)

cl00040
Location:173 → 223

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
XM_036157195.1 → XP_036013088.1 diacylglycerol kinase zeta isoform X13

Conserved Domains (5) summary

smart00045
Location:225 → 382

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:76 → 197

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

sd00045
Location:615 → 648

ANK; ANK repeat [structural motif]

pfam12796
Location:587 → 681

Ank_2; Ankyrin repeats (3 copies)

cl00040
Location:1 → 23

C1; protein kinase C conserved region 1 (C1 domain) superfamily
XM_006498537.2 → XP_006498600.1 diacylglycerol kinase zeta isoform X1

Conserved Domains (5) summary

smart00045
Location:641 → 798

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:492 → 613

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

sd00045
Location:1031 → 1064

ANK; ANK repeat [structural motif]

pfam12796
Location:1003 → 1097

Ank_2; Ankyrin repeats (3 copies)

cl00040
Location:367 → 417

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
XM_006498538.3 → XP_006498601.1 diacylglycerol kinase zeta isoform X2

Conserved Domains (5) summary

smart00045
Location:641 → 798

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:492 → 613

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

sd00045
Location:1030 → 1063

ANK; ANK repeat [structural motif]

pfam12796
Location:1002 → 1096

Ank_2; Ankyrin repeats (3 copies)

cl00040
Location:367 → 417

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
XM_017314867.2 → XP_017170356.1 diacylglycerol kinase zeta isoform X3

Conserved Domains (5) summary

smart00045
Location:641 → 798

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:492 → 613

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

sd00045
Location:980 → 1016

ANK; ANK repeat [structural motif]

pfam12796
Location:990 → 1084

Ank_2; Ankyrin repeats (3 copies)

cl00040
Location:367 → 417

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
XM_017314878.1 → XP_017170367.1 diacylglycerol kinase zeta isoform X11

Conserved Domains (5) summary

smart00045
Location:327 → 484

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:178 → 299

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

sd00045
Location:717 → 750

ANK; ANK repeat [structural motif]

pfam12796
Location:689 → 783

Ank_2; Ankyrin repeats (3 copies)

cl00040
Location:53 → 103

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
XM_017314875.2 → XP_017170364.1 diacylglycerol kinase zeta isoform X11

Conserved Domains (5) summary

smart00045
Location:327 → 484

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:178 → 299

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

sd00045
Location:717 → 750

ANK; ANK repeat [structural motif]

pfam12796
Location:689 → 783

Ank_2; Ankyrin repeats (3 copies)

cl00040
Location:53 → 103

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
XM_011239241.4 → XP_011237543.1 diacylglycerol kinase zeta isoform X12

Conserved Domains (3) summary

smart00046
Location:492 → 613

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

cl00040
Location:367 → 417

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cl02440
Location:641 → 727

DAGK_acc; Diacylglycerol kinase accessory domain
XM_011239244.2 → XP_011237546.1 diacylglycerol kinase zeta isoform X14

Conserved Domains (2) summary

smart00046
Location:492 → 594

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

cl00040
Location:367 → 417

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...